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Can curcumin modulate allergic rhinitis in rats?
(Cambridge Univ Press, 2016) Acar, M.; Muluk, N. Bayar; Yigitaslan, S.; Cengiz, B. P.; Shojaolsadati, P.; Karimkhani, H.; Cingi, C.
Objectives: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined. Results: The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria. Conclusion: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.