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Öğe Adaptation Study of the Newest Vital Sign on Adolescents With Type 1 Diabetes and Healthy Adolescents in Turkish(Lippincott Williams & Wilkins, 2022) Gumus, Aylin Bayindir; Keser, Alev; Siklar, Zeynep; Berberoglu, MerihThe current study aimed to establish validity and reliability of the Newest Vital Sign (NVS) in 255 Turkish adolescents aged 11 to 18 years with and without type 1 diabetes and evaluate their health literacy with age, gender, and health status. The t values of items in the NVS were found to be statistically significant and the calculated Cronbach's alpha coefficient value indicated that the reliability is at a medium level; 7.5%, 42%, and 56.5% of adolescents had respectively inadequate, limited, and adequate health literacy. There is a negative relationship between the health literacy of adolescents with diabetes and their HbA(1c) (P < .05). This study confirms that the NVS is a valid and reliable tool for Turkish adolescents.Öğe Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey(Galenos Yayincilik, 2019) Eren, Erdal; Ergur, Ayca Torel; Isguven, Sukriye Pinar; Bitkin, Eda Celebi; Berberoglu, Merih; Siklar, Zeynep; Tarim, OmerObjective: We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases of pediatric hyperprolactinemia in a large multicenter study. Methods: We reviewed the records of 233 hyperprolactinemic patients, under 18 years of age, who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia and idiopathic hyperprolactinemia. Complaints of the patients, their mode of treatment (medication and/or surgery) and outcomes were evaluated in detail. Results: The mean age of the patients with hyperprolactinemia was 14.5 years, and 88.4% were females. In terms of etiology, microadenomas were observed in 32.6 %, macroadenomas in 27 %, idiopathic hyperprolactinemia in 22.7% and drug-induced hyperprolactinemia in 6.4 %. Other causes of hyperprolactinemia were defined in 11.3%. Common complaints in females (n = 206) were sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea and weight gain, whereas headache, gynecomastia, short stature and blurred vision were common in males (n = 27). Median prolactin levels were 93.15 ng/mL, 241.8 ng/ml, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for microadenomas, macroadenomas, idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and other causes of hyperprolactinemia, respectively. Of 172 patients with hyperprolactinemia, 77.3 % were treated with cabergoline and 13.4 % with bromocriptine. 20.1 % of the patients with pituitary adenomas underwent pituitary surgery. Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised.Öğe Clinical And Laboratory Characteristics Of Hyperprolactinemic Children And Adolescents: National Survey(Karger, 2017) Eren, Erdal; Ergur, Ayca Torel; Isguven, Sukriye Pinar; Bitkin, Eda Celebi; Berberoglu, Merih; Siklar, Zeynep; Tarim, Omer…Öğe Clinical characteristics and response to growth hormone treatment in patients with Prader-Willi Syndrome(Karger, 2019) Evliyaoglu, Olcay; Cakir, Aydilek Dagdeviren; Bas, Firdevs; Akin, Onur; Siklar, Zeynep; Ozcabi, Bahar; Berberoglu, Merih[Abstract No tAvailable]Öğe How does an additional insulin dose for a high-fat, high-protein breakfast affect glysemic response in adolescents with type 1 diabetes?(Marmara Univ, Fac Medicine, 2023) Gumus, Aylin Bayindir; Keser, Alev; Siklar, Zeynep; Berberoglu, MerihObjective: In this study, it was aimed to evaluate the effects of an additional insulin dose for high-fat and high-protein meal on blood glucose levels in adolescents with type 1 diabetes.Patients and Methods: This study was single-center, crossover, and randomized. Seven adolescents with type 1 diabetes between the ages of 14 and 17 were given breakfast containing high-fat (45.9% energy) and high-protein (21.9% energy) for two consecutive days, and two different insulin doses were administered. According to the first application dose of carbohydrate/insulin ratio, the second application was given this dose of additional insulin up to 30% in postprandial 180th minute. Blood glucose was monitored for 360 minutes at 30-minute intervals using a continuous glucose monitoring system (CGMS).Results: The average time spent in the target range (TIR) of participants was 30.6 +/- 11.83%, and time spent in hyperglycemia and hypoglycemia (time above range (TAR) and time below range (TBR)) were 67.0 +/- 14.31% and 2.4 +/- 4.89%, respectively. There was no statistically significant difference between the early (0-120th min), late (120-360th min), and total (0-360th min) glycemic responses of the applications (p>0.05). According to CGMS result, mean blood glucose, glycemic variability, and absolute blood glucose difference median and mean absolute deviation (MAD%) were found to be similar after two applications (p>0.05).Conclusion: Insulin dose applications should be individually calculated to prevent delayed-prolonged postprandial hyperglycemia caused by high-fat high - protein intake in adolescents with type 1 diabetes.Öğe Life quality in girls with Turner syndrome a cross sectional study(Karger, 2008) Bideci, Aysun; Evliyaoglu, Olcay; Cetinkaya, Ergun; Aycan, Zehra; Berberoglu, Merih; Siklar, Zeynep; Yesilkaya, Ediz[Abstract No tAvailable]
