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    Expression of CYP and GST in human normal and colon tumor tissues
    (Taylor & Francis Ltd, 2019) Bulus, H.; Oguztuzun, S.; Simsek, G. Guler; Kilic, M.; Ada, A. Oguz; Gol, S.; Iscan, M.
    We investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues. Tissues were obtained from 47 patients with colon adenocarcinoma and the staining intensity of tumor and control tissues was compared. CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTT1, GSTO1 and GSTK1 expressions in colon cancer cells were significantly greater than those in normal colon epithelial cells. No significant relation was found between the isoenzyme expressions and age, gender, smoking status, tumor grade and tumor stage. The higher expressions of CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTO1, GSTT1 and GSTK1 in tumor than in normal colon tissues may be important for colon cancer progression and development.
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    Isolated itching of external auditory canal: clinicopathological study with immunohistochemical determination of antimicrobial peptides
    (Cambridge Univ Press, 2011) Acar, B.; Simsek, G. Guler; Oguztuzun, S.; Zaim, M.; Karasen, R. Murat
    Objective: This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal. Materials and methods: A prospective, case-control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human beta-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared. Results: There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p < 0.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls (p > 0.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human beta-defensin-3 or LL-37 cathelicidin. Conclusion: Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis.