Yazar "Simsek, Yavuz" seçeneğine göre listele
Listeleniyor 1 - 8 / 8
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Atorvastatin exerts anti‑nociceptive activity and decreases serum levels of high‑sensitivity C‑reactive protein and tumor necrosis factor‑α in a rat endometriosis model(Springer Heidelberg, 2014) Simsek, Yavuz; Gul, Mehmet; Yilmaz, Ercan; Ozerol, Ibrahim Halil; Ozerol, Elif; Parlakpinar, HakanPurpose The purpose of this study was to examine the effects of atorvastatin in the treatment of experimental endometriosis. Methods Endometriosis was induced in 24 female rats. 4 weeks after the procedure dimensions of the foci were recorded. Rats were divided into three groups: in Group 1 (n = 8), a daily dose of 10 mg/kg atorvastatin was given for 14 days. In the second group (n = 8), a single dose of 1 mg/kg leuprolide acetate was injected intraperitoneally. The rats in Group 3 (n = 8) were received 1 mg/kg i.p. 0.9 % NaCl. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriotic foci were recorded. Biochemical, histopathological and immunohistochemical studies were performed and nociception was compared in groups. Results Atorvastatin treatment exhibited significant analgesic activity in hot plate model (P = 0.022). The serum hs-CRP and tumor necrosis TNF-alpha levels were similar between the Group 2 and Group 3 (P > 0.05); however atorvastatin caused significant decrease in both serum markers. The histological and immunohistochemical scores were also found to be markedly lower in Group 1 and Group 2 (P < 0.05). Conclusion Atorvastatin treatment may have a therapeutic potential in the treatment of endometriosis through its anti-inflammatory and anti-nociceptive properties.Öğe Atypical eclampsia and postpartum status epilepticus(African Field Epidemiology Network-Afenet, 2015) Dag, Zeynep Ozcan; Isik, Yuksel; Turkel, Yakup; Alpua, Murat; Simsek, YavuzPreeclampsia is an entity that may present from 20th week of gestation up to 48 hours postpartum and is associated with hypertension and proteinuria. Eclampsia is emergence of convulsions pre-eclampsia in pregnant women with signs and symptoms. Recent studies showed that in some women, preeclampsia and even eclampsia may occur without hypertension or proteinuria. Here, we present a case of 26 years old women who had an uneventful pregnancy until 30 weeks' of gestation. She had only proteinuria in laboratory tests and was diagnosed as status epilepticus in early postpartum period. Preeclampsia and eclampsia is related with serious fetal and maternal morbidity and mortality and may present with atypical course. The awareness of atypical cases of preeclampsia enhances early diagnosis and management which are critical to avoid feto-maternal complications.Öğe Effect of vaginal cleansing on postoperative factors in elective caesarean sections: a prospective, randomised controlled trial(Taylor & Francis Ltd, 2017) Goymen, Abdullah; Simsek, Yavuz; Ozdurak, Halil Ibrahim; Ozkaplan, Sukran Esra; Akpak, Yasam Kemal; Ozdamar, Ozkan; Oral, SerkanObjective: To assess the effect of povidone iodine versus benzalkonium chloride, which were applied preoperatively for vaginal disinfection in caesarean sections, on postoperative factors. Methods: One hundred and twenty patients underwent elective caesarean section were divided into three groups using the simple randomisation method: Group 1 (povidone iodine, n: 41); Group 2 (benzalkonium chloride, n: 39); Group 3 (control group, n: 40). Demographic data, duration of operation, amount of bleeding, postoperative pain, time to first flatulence and defaecation, haematological parameters on postoperative day 1 were compared between three groups. Pain evaluation was performed at 6th and 24th postoperative hour using Visual Analogue Scale. Results: No statistically significant differences were detected between the groups in demographic characteristics. There were no significant differences between the groups with respect to the duration of operation and hospital stay. The patients in the group who underwent povidone iodine vaginal cleansing had statistically significantly less postoperative pain as compared to control group. No difference was observed between the groups in haematological parameters other than C-reactive protein (CRP); however, CRP levels at 24th post-operative hour were significantly lower in Group 1 compared to the other groups. Conclusions: The preoperative vaginal cleansing with povidone iodine could reduce the postoperative pain, analgesic need and infection parameter.Öğe Impacts of Childbirth on the Subsequent Risk of Stress Urinary Incontinence(Duzce Univ, 2018) Ozdurak, Ibrahim; Goymen, Abdullah; Simsek, Yavuz; Ozakin, Ekrem; Akpak, Yasam Kemal; Sik, Aytek; Sari, OktayObjective: The purpose of the this study was to indicate the role of childbirth parameters on the development of stress urinary incontinence (SUI). Methods: One hundred-one healthy women (control group) and 98 patients with SUI (study group) were included in this study between March 2008 and April 2009. Obstetric history of participants was taken and labor parameters were compared between control group and study group. Results: The prevalence of SUI reported in the study was 43.9%. The result of prevalence was 43.9% during the study. Parity and gravidity was significantly more in study group (p<0.001). Vaginal delivery, Kristeller manauver, operative delivery by vacuum or forceps extraction and delivery of macrosomic fetus was found to be significant risk factors for SUI (p<0.05). Conclusions: Mode of delivery and obstetric history have significant impact on subsequent SUI. Timely cesarean section in women with obstructed labor may prevent the later occurrence of SUI.Öğe Marked changes in olfactory perception during early pregnancy: a prospective case-control study(Springer, 2015) Simsek, Gokce; Muluk, Nuray Bayar; Arikan, Osman Kursat; Dag, Zeynep Ozcan; Simsek, Yavuz; Dag, ErselPregnancy seems to be related with a significant change in olfaction. Here, we investigate this theory by testing the odor identification abilities of uncomplicated pregnant women and compare the results with non-pregnant controls. The study included 31 healthy pregnant women in the first trimester (Group 1), 30 in the second trimester (Group 2), 31 in the third trimester, and 30 non-pregnant healthy controls (Group 4). In order to measure odor identification abilities, each subject completed the 12-item Brief Smell Identification Test (BSIT). Next, the demographic characteristics and BSIT scores of the groups were compared. The total BSIT scores of the subjects in Group 1 were found to be significantly lower than those of the other groups (p < 0.001). This reduction in odor identification abilities was particularly noticeable for leather, pine, and soot. Pregnant women in the second and third trimesters had similar odor identification abilities to the healthy controls (p > 0.05). Early pregnancy might be related to significant changes in olfactory performance. The distortion of odor identification in the first trimester might be a causative factor for the development of pregnancy-specific conditions, such as morning sickness and hyperemesis gravidarum, which are both common complaints during the early phase of parturition.Öğe Mode of delivery changes oxidative and antioxidative properties of human milk: a prospective controlled clinical investigation(Taylor & Francis Ltd, 2015) Simsek, Yavuz; Karabiyik, Pinar; Polat, Kubra; Duran, Zeynep; Polat, AlaaddinObjective: To evaluate the influence of delivery mode on oxidative stress in human breast milk. Methods: Thirty-three women who delivered by vaginal birth and 55 women who underwent cesarean section (CS) were included in this study. Colostral samples were collected on the second day after delivery. Total antioxidative status (TAS), total oxidative status (TOS), oxidative stress index (OSI), malonyldialdehyde (MDA), and glutathione peroxidase (GSH-Px) levels were determined and compared. Results: Colostrum TAS was significantly higher in women of vaginal birth, than in women with CS (p<0.001). Milk TOS and OSI were found to be significantly increased in women with CS under general anesthesia. A marked increase in colostral GSH-Px levels after vaginal delivery was also noticed (p<0.001). Conclusion: This study revealed that vaginal birth is associated with decreased oxidative stress in colostrum than CS, which suggest that mode of delivery plays an important role in the antioxidative production of breast milk.Öğe Olfactory dysfunction and oxidative stress in pregnant women with hyperemesis gravidarum(Springer Heidelberg, 2021) Simsek, Yavuz; Simsek, Gokce; Muluk, Nuray Bayar; Arikan, Osman KursatPurpose This study aimed to compare the first-trimester pregnancy serum total oxidative status (TOS), total antioxidant status (TAS), and serum estradiol levels as well as the olfactory functions assessed using the brief smell identification test (BSIT) of women with healthy pregnancies and those with hyperemesis gravidarum (HG). Methods In this prospective study, 60 pregnant women in the first trimester of their pregnancies were divided into two groups: 30 pregnant women with HG (study group) and 30 healthy pregnant women (control group). The following parameters were compared in the HG group and the healthy controls: TOS, TAS, serum levels of estradiol (E2), and olfactory function, which was measured using BSIT. Results Both groups were similar in terms of age, gravida, and parity. The mean total smell score was lower in the HG group than the healthy control group (p < 0.05). TOS was significantly higher in the HG group than the control group. TAS was significantly higher in the control group than the HG group (p < 0.05). Conclusion The removal of sharp odors that will trigger the perception of odor in pregnant women with HG can contribute to the effective control of this disease; moreover, adding fetal-safe antioxidants to the treatment can contribute to the effective control of this disease.Öğe The relationship between the helicobacter pylori seropositivity with systemic and local oxidative status and hyperemesis gravidarum: a pilot study(Taylor & Francis Ltd, 2018) Goymen, Abdullah; Ozdurak, Ibrahim; Ozkaplan, Sukran Esra; Simsek, Yavuz; Avci, Fazil; Akpak, Yasam KemalObjectives: The aim of study was to determine the helicobacter pylori (HP) seropositivity and oxidative parameters in serum and saliva of pregnant women with poor oral hygiene and hyperemesis gravidarum (HG).Methods: A case-control study was conducted involving 50 pregnant women in their first trimester of pregnancy. Twenty-five subjects had a diagnosis of HG, and remaining 25 were healthy pregnant women who served as control subjects were included. The groups were adjusted for age, parity and gestational week. All patients were subjected to the measurement of total oxidant status (TOS) and total antioxidant status in serum and saliva. Also HP seropositivity was investigated.Results: Serum TAS and TOS values were similar, although oxidative burden in saliva of women with HG were significantly higher than controls. HP seropositivity was found to be 24% in women with HG and 4% of controls.Conclusions: Our results suggest that significantly increased oxidative burden and slightly decreased antioxidative capacity of saliva may be involved in the pathogenesis of HG and this condition may be the result of HP infection which was found to be significantly more common in women with poor oral hygiene and HG.
