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    New pathway in rheumatic mitral valve disease: Cytochrome P450 and glutathione S transferase isozyme expression
    (De Gruyter Open Ltd, 2020) Simsek E.; Simsek G.; Soyal M.F.T.; Kaygin P.; Oguztuzun S.; Duzgun A.C.; Sarialtin S.
    Objective: Cytochrome P450 (CYP)1A1, glutathione S-transferase pi (GSTP1) and omega (GSTO1) isozymes were evaluated and compared in patients with the diagnosis of rheumatic mitral valve disease and ischemic mitral valve insufficiency to find out the relationship of the oxidative stress with rheumatic mitral valve disease. Materials and methods: The control group consisted of patients operated on due to ischemic mitral valve insufficiency (group I, n:14) while study group consisted of the patients operated on with the diagnosis of rheumatic mitral valve disease (group II, n:29). Mitral valve materials were stained with hematoxylin and eosin. CYP1A1, GSTP1, and GSTO1 immunohistochemical markers were studied. Results: 20.7% of GSTP1 isozyme protein expression was seen in the study group; however, no expression was detected in the control group. This finding was statistically significant in terms of GSTP1 isozyme. No statistically significant differences in the level of GSTO1 and CYP1A1 protein expression between the study and control groups were observed. Conclusion: In this study, we found out that GSTP1 isozyme may be related to rheumatic mitral valve disease. A strategy that would help prevent oxidative stress in patients with rheumatic mitral valve disease can be a so valuable means to affect disease progression. © 2020 De Gruyter. All rights reserved.
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    The presence of Clival foramen through Multidetector computed tomography of the skull base
    (Lippincott Williams and Wilkins, 2015) Inal M.; Muluk N.B.; Ozveren M.F.; Celebi U.O.; Simsek G.; Burulday V.; Bilgili M.Y.K.
    Objectives: Technological advancements in the diagnostic radiology recently permitted reviewing the normal anatomy through multidetector computed tomography (MDCT) imagination. The aim of this paper is retrospectively investigation of the clival foramen and canal through MDCT. Materials and Methods: One hundred eighty-six MDCT scans were reviewed. First, images were taken at axial plane, and then coronal and sagittal reconstructions of raw data were performed. Later investigations were carried out on these three-dimensional images (3-D imaging). The images were evaluated as clival foramen ''present'' or ''absent.'' Results: In our 186 patients, evaluation of MDCT showed that clival foramenwas absent in 66.7% (n=124) of patients. Only 33.3% (n=62) of patients had a clival foramen. In 3-D images, clival canal and clival foramen were shown more clearly compared with the MDCT. Conclusions: Knowledge of the clival canal might be useful in patients of questionable clival fracture or during neurosurgical operations in this region. During life the canal contained a vein connecting the basilar plexus with the venous plexus of the vertebral canal, and inferior petrosal sinuses. Before the surgical interventions in the clival region, the presence of the clival canal and foramen should also be known due to its vascular contents. By multidetector computed tomography and 3-D images, clival canal and foramen may be viewed preoperatively. Copyright © 2015 by Mutaz B. Habal, MD.