Yazar "Soyer, T." seçeneğine göre listele
Listeleniyor 1 - 8 / 8
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Dysfunctional voiding in children with asthma (conferenceObject)(Wiley-Blackwell, 2011) Soyer, Uysal O.; Kilincoglu, B.; Senyucel, Fedakar M.; Arslan, K.; Cakmak, M.; Dallar, Y.; Soyer, T.…Öğe The effect of penile urethral fat graft application on urethral angiogenesis(Elsevier Sci Ltd, 2015) Cakmak, M.; Yazici, I.; Boybeyi, O.; Ayva, S.; Aslan, M. K.; Senyucel, M. F.; Soyer, T.Background Autologous fat grafts are rich in adipose-derived stem cells, providing optimal soft-tissue replacement and significant quantities of angiogenic growth factor. Although fat grafts (FG) are used in several clinical conditions, the use of FG in urethral repairs and the effects of FG to urethral repairs have not yet been reported. Objective An experimental study was performed to evaluate the effect of FG on urethral angiogenesis and tissue growth factor (GF) levels. Study design Sixteen Wistar albino, adult, male rats were allocated into two groups: the control group (CG) (n = 8) and the experiment group (EG) (n = 8). After anesthetization of all rats, 3-mm vertical incisions were made on the urethras, and then sutured with interrupted 5/0 vicryl sutures. The operations were performed under a stereo dissecting microscope under magnification (x20). In the CG, no additional procedure was performed. In the EG after the same surgical procedure, 1 mm(3) FG was removed from the inguinal region by sharp dissection with a knife. The grafts were trimmed to 1 x 1 mm dimensions on millimeter paper. The FGs were placed on the repaired urethras. The skin was then closed. Samples from urethral and penile skin were taken 21 days after surgery in both groups. Density and intensity of staining with vascular-endothelial GF (VEGF), VEGF-receptor, and endothelial-GF receptor (EGFR) in the endothelial and mesenchymal cells of the penile urethral vessels were immunohistochemically evaluated. Data obtained from immunohistochemical evaluations were analyzed with SPSS 15.0. The P-values lower than 0.05 were considered as significant. Results Density of VEGF staining was significantly decreased in the vascular endothelium of the EG compared to the CG (P < 0.05). Density of the EGFR staining was significantly decreased in the vascular endothelium of the EG compared to the CG (P < 0.05) (Table). Intensity of VEGF, VEGF-R and EGFR staining was not significantly different between the two groups. There were no significant differences between groups regarding to VEGFR staining and mesenchymal examination. Discussion Decreased density was found in the VEGF staining in the vascular endothelium. This could be explained by the day that the tissues were harvested or because autologous fat grafts might cause decreased growth factor levels, which is contrary to the literature data. Conclusion Fat grafting has an immunohistochemical effect on the growth factor levels that are related to angiogenesis after urethral repair. It is difficult to make a firm conclusion about the role of fat grafting on urethral healing. Therefore, future studies are needed to see if FG can be used as an alternative to other procedures in order to avoid complications.Öğe Effect Of Phototheraphy On Gastrointestinal Smooth Muscle Activity And Oxidative Stress On Intestinal Segments(Wiley-Blackwell Publishing, Inc, 2009) Soyer, T.; Aliefendioglu, D.; Aktuna, Z.; Cağlayan, O.; Aydos, T. R.; Cakmak, M.…Öğe Electrophysiological evaluation of cremasteric reflex in experimental testicular torsion(Georg Thieme Verlag Kg, 2007) Soyer, T.; Tosun, A.; Somuncu, S.; Aydin, G.; Akman, H.; Inal, E.; Cakmak, M.Aim: The aim of the study was the electrophysiological evaluation of the cremasteric reflex after experimental testicular torsion. Material and Methods: Ten male Wistar rats were enrolled into the study. Genitofemoral nerve (GFN) motor conduction and cremasteric reflex (CR) responses were evaluated electrophysiologically after being subjected to anesthesia with intramuscular ketamin hydrochloride. Testicular torsion was performed by rotating the right testicle 720 in a clockwise direction from a mid-scrotal incision. Electrophysiological evaluations were repeated in the early (30 minutes) and late (90 minutes) periods of testicular torsion. Subsequently, detorsion of the testicles was performed and electrophysiological recordings were completed after 60 minutes of detorsion. The CR was also evaluated clinically before each electrophysiological evaluation. The latency and duration of GFN motor conduction and CR responses was compared for base, early torsion, late torsion and detorsion recordings. Friedman's test for repeated measurements was used for statistical analysis. Results: The CR, which was detected clinically before torsion and after detorsion, was not detected during torsion. When base, early torsion, late torsion and detorsion recordings were compared, there was no statistical difference with respect to both latency and duration of GFN motor conduction and CR responses (p > 0.05). Conclusion: Although CR was not detected clinically during testicular torsion, the electrophysiological parameters of the reflex did not differ in the early and late periods of torsion in rats. The GFN motor conduction parameters also showed no differences. In conclusion, the absence of the CR after testicular torsion could not be confirmed by electrophysiological studies.Öğe Evaluation of contralateral kidney, liver and lung after extracorporeal shock wave lithotripsy in rabbits(Springer, 2013) Senyucel, M. F.; Boybeyi, O.; Ayva, S.; Aslan, M. K.; Soyer, T.; Demet, A. I.; Cakmak, M. A.An experimental study was carried out to evaluate the effects of extracorporeal shock wave lithotripsy (ESWL) on contralateral kidney, liver and lung by histopathological and biochemical methods. Twelve New Zealand rabbits were allocated to two groups (n = 6). Tissues of control group (CG, n = 6) were harvested without any intervention. In ESWL group (EG), right kidneys were exposed to 3,000 shock waves at 14 kV energy using electro-hydraulic type ESWL device three times every other day. Both kidneys, liver, and right lobe of lung tissues in EG were harvested on seventh day. Kidneys were examined histopathologically for presence of glomerular and tubular injury, interstitial edema, congestion, inflammation and fibrosis. Livers were examined for hepatocyte vacuolization, congestion, portal inflammation and fibrosis. Lung tissues were examined for loss of normal structure, emphysema, interstitial congestion-edema, prominent alveolar septal vessels, interstitial inflammation, intra-alveolar hemorrhage, intraluminal hemorrhage, peribronchial edema, congestion, inflammation in bronchial wall and epithelial desquamation. Biochemical analysis of tissue samples was performed for oxidative injury markers. Histopathological evaluations revealed that tubular injury was found in both shocked and contralateral kidneys (p < 0.05). EG showed higher grades of portal fibrosis in liver and higher grades of peribronchial congestion in lung when compared to CG (p < 0.05). Biochemical evaluations of both kidneys showed that malondialdehyde levels were higher in EG than in CG (p < 0.05). ESWL causes histopathologic alterations both in shocked and contralateral kidneys. Extrarenal tissues such as liver and lung can be affected by shock waves histopathologically and oxidative injury of contralateral kidney may occur acutely after ESWL.Öğe In vitro sensitivity of rat esophagus to agonists in different alkaline mediums (conferenceObject)(Wiley-Blackwell Publishing, Inc, 2009) Hancerliogullari, Oe; Cakmak, M.; Soyer, T.; Aktuna, Z.…Öğe Rare gallbladder parasitosis mimicking cholelithiasis: Dicrocoelium dendriticum(Georg Thieme Verlag Kg, 2008) Soyer, T.; Turkmen, F.; Tatar, N.; Bozdogan, Oe; Kul, O.; Yagmurlu, A.; Cakmak, M.Choleithiasis is increasingly diagnosed in childhood and infancy. Biliary parasites are the rarest cause of cholelithiasis in all age groups. We present a twelve-year-old girl with non-hemolytic gallbladder stone and discuss the clinical features and differential diagnosis of Dicrocoelium dendriticum (DD) invasion that causes and/or mimics cholelithiasis in children.Öğe Surgical Repair of Treves' Field Mesenteric Hernia: Use of the Purse-string Technique(Georg Thieme Verlag Kg, 2011) Cakmak, M.; Senyucel, M. F.; Aslan, M. K.; Soyer, T.…
