Yazar "Tüz, Hakan H." seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Experimental evaluation of the effects of zoledronic acid on regenerate bone formation and osteoporosis in mandibular distraction osteogenesis(W B Saunders Co-Elsevier Inc, 2006) Pampu, A. Alper; Dolanmaz, Doğan; Tüz, Hakan H.; Karabacakoğlu, AydinPurpose: The aim of this study was to evaluate the effects of systemically administered zoledronic acid (ZA) on the bone mineral density (BMD) and bone mineral content (BMC) at mandibular distraction sites in rabbits. Materials and Methods: Eighteen New Zealand white rabbits were randomly divided into 2 groups. Bone lengthening was performed in the left portion of the mandible through distraction osteogenesis at a rate of 0.5 mm every 12 hours for 5 days. While the experimental group rabbits were administered intravenous 0.1 mg/kg ZA, control group rabbits were given only saline infusion during operation. All animals were sacrificed at the end of the consolidation period of 28 days. The mandibles of all animals were removed and both the anterior and posterior pin regions of the regenerate and regenerate region were evaluated by dual energy x-ray absorptiometry (DEXA). BMD and BMC data were statistically analyzed. Results: Except for 1 rabbit from the experimental group that had an infection at the external pin region, all animals showed complete clinical healing. When the values in the group receiving ZA were compared with those of the control group, it was observed that the BMD values of the anterior pin region of regenerate, regenerate region, and posterior pin region increased by 23%, 20%, and 31%, respectively; and BMC values increased by 22%, 24%, and 32%, respectively. When data of these regions were compared, both BMD and BMC were found statistically different in all regions (P <.05). Conclusion: Results of this study showed that ZA had positive effects on new bone formation at and around the distraction gaps of the lengthened rabbit mandibles by distraction osteogenesis. (C) 2006 American Association of Oral and Maxillofacial Surgeons.Öğe Histomorphometric evaluation of delayed changes in masseter muscle after lengthening the rabbit mandible by distraction osteogenesis(Wiley, 2009) Tüz, Hakan H.; Dolanmaz, Doğan; Pampu, A. Alper; Kişnişçi, Reha S.; Günhan, O.The aim of the study was to evaluate the delayed responses and changes of gradually lengthened masseter muscles of rabbit mandibles. Unilateral lengthening of rabbit mandibles was performed in 18 New Zealand rabbits for 7 days at the rate of 1 mm day(-1). Mandibles of animals were removed at months 3, 4, and 6 after distraction. Biopsy samples of distracted and contralateral side masseter muscles were histopathologically evaluated and mean area of muscle fibers (MAF) was evaluated with histomorphometric methods. Results were statistically analyzed. Mild to moderate atrophy of the fibers, and necrosis and myophagocytosis in some areas were the leading features at month 3 and which were decreased at month 4 in distracted side-muscle specimens, with no statistically significant differences when compared with non-distracted side muscles at the same periods. Almost completely, normal fibers were detected in distracted muscle specimens at month 6. Evidence of myopathic changes was found to disappear at month 6 and no significant difference was found in the MAF of distracted side muscles. This study showed that the masseter muscle could adapt to gradual lengthening of the mandible within 6 months. Regenerative features and some degree of atrophic changes that could be observed at months 3 and 4 disappeared at month 6, with adaptation of the fibers.Öğe Histomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbits(W B Saunders Co-Elsevier Inc, 2008) Pampu, A. Alper; Dolanmaz, Dogan; Tüz, Hakan H.; Avunduk, M. Cihat; Kisnisci, Reha S.Purpose: To assess the effect of systemic administration of zoledronic acid (ZA) on mineralization of newly formed bone and to determine strain-related osteoporosis on surrounding bone during lengthening of immature rabbit mandible. Materials and Methods: Eighteen New Zealand white rabbits were divided randomly into 2 groups, and bone lengthening was carried out in the left portion of the mandible through distraction osteogenesis with a rate of 0.5 mm every 12 hours for 5 days. The experimental group was administered 0.1 mg/kg ZA intravenously. The control group was given saline infusion only during operation. All animals were sacrificed at the end of the 28-day consolidation period. The mandibles of all animals were removed and regenerate was evaluated. Osteoblasts, osteoclasts, collagen fibers, and fibroblasts were marked within 0.1-mm(2) area and newly formed bone area was measured within 0.5-mm(2) area. All data were analyzed using Mann-VAiitney U test. Results: Although irregular bone destruction spots were seen in the control group, the experimental group showed regular ossification areas and significant difference between osteoblast and osteoclast numbers (P < .05). In the regenerate zone, there was considerable difference between the 2 groups in terms of osteoblast, osteoclast, and collagen amounts (P < .05). Additionally, newly formed bone areas and fibroblast count were higher in experimental group. Conclusions: The results of this study showed that ZA had positive effects on the new bone formation, which may potentially shorten the consolidation period. (c) 2008 American Association of Oral and Maxillofacial Surgeons.Öğe Long-term results of arthrocentesis in degenerative temporomandibular disorders(Mosby-Elsevier, 2009) Önder, M. Ercüment; Tüz, Hakan H.; Koçyiğit, Doruk; Kişnişçi, Reha S.Objectives. Long-term efficacy of arthrocentesis was investigated in patients with degenerative temporomandibular disorder (TMD) in this clinical study. Study design. Twenty-two joints of 15 patients with degenerative TMD were included as the study group, and 16 joints of 10 patients served as the control group. Arthrocentesis procedures in upper joint spaces were performed. The study group patients' mean follow-up period was 36.7 +/- 18.7 months, whereas the control group were kept for an average 9.9 +/- 2.8 months. Results were statistically compared using 1-way repeated analysis of variance and t test. Results. Pretreatment maximal interincisal opening increased significantly from 33.6 +/- 6.0 mm to 37.8 +/- 6.0 mm in the study group. Pretreatment pain and crepitus scores decreased significantly from 71.0 +/- 6.6 to 27.0 +/- 16 and 0.73 +/- 0.4 to 0.6 +/- 0.5, respectively, in the study group. Conclusions. Arthrocentesis was found to be a useful method for the treatment of degenerative TMDs, and the outcomes of treatment provide long-term cure for degenerative temporomandibular joints. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: e1-e5)Öğe Use of spongious bone chips and fascia temporalis in alveolar bone defects(2004) Tüz, Hakan H.; Akal, Ümit K.; Cambazoğlu, Mine; Kişnişçi, Reha Ş.Graft materials are used for inducement of regeneration in bone defects. Organic and synthetic bone graft materials facilitate remodelation or healing of the bone and induce new bone formation in the area of bone resorption caused by pathological, traumatic, and physiological reasons. The aim of this study was to evaluate the effects of spongious allogenic bone graft and fascia temporalis membranous collagen tissue on the healing of bone defects clinically and radiologically. The study was carried out on 90 bone defects of 81 patients who underwent apicoectomy, cystectomy, and curettage of chronic infections in the maxilla and mandible. Defects were divided into 3 groups with respect to the way they were treated before soft tissue flap closure: with bone chips alone (D1), with bone chips and fascia temporalis (D2), and with no treatment (D3). Clinical and radiological examinations were carried out 1, 3, 6, and 12 months after surgery. Complications were observed in 5 defects in D1, 4 defects in D2, and 5 defects in D3. All defects ameliorated after treatment of the complications. All 3 groups showed similar complication rates after surgery. Spongious bone chips either alone or covered with fascia temporalis reduced the overall osteogenesis period and prevented collapse of the mucosal soft tissue into the defect when compared with the controls.
