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Öğe Benign vokal kord patolojisi nedeniyle opere edilen hastaların retrospektif incelenmesi(2019) Taş, Burak Mustafa; Şimşek, Gökce; Balcı, Mahi; Kılıç, RahmiAmaç: Kliniğimizde opere olan benign vokal kord lezyonları hastaların patolojik ve klinik verilerinin sunulması ve dağılım yüzdelerinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Çalışma Kırıkkale Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalında Aralık 2013 - Mart 2017 tarihleri arasında benign vokal kord lezyonları tanısı alan hasta dosyalarının retrospektif olarak değerlendirilmesi ile gerçekleştirilmiştir.Bulgular: Ortalama yaşları 47,8 olan toplam 108 hastanın verileri incelendi. Hastaların 24’ü (%22,3) kadın 84’ü (%77,7) erkek idi. Hastaların patoloji sonuçları 61 (%56,4) vokal kord polipi, 20 (%18,5) değişik derecelerde keratotik lezyon olan lökoplazi, 11 (%10,1) Reinke ödemi, 7 (%6,4) larengeal kist, 6 (%5,5) vokal kord nodülü, 2 (%1,8) larinks papillomatozu ve 1 (%0,9) larengosel olarak kaydedildi. Hastaların 76’sının (%70,3) anamnezinde sigara öyküsü olduğu gözlendi.Sonuç: Benign vokal kord lezyonları bulunan hastaların patoloji sonuçlarında en sık vokal kord polipi ile karşılaşılmaktadır. Her kliniğin benign vokal kord lezyonları patoloji sonuçlarının değerlendirilmesi ile ülkemizdeki benign vokal kord lezyonları sonuçlarının dağılımı ile ilgili veriler oluşturulabilir.Öğe Bilateral Nasoalveolar Cyst Causing Nasal Obstruction(2018) Tozar, Mesut; Şimşek, Gökce; Taş, Burak Mustafa; Daphan, Birsen Ünal; Kılıç, RahmiNasoalveolar cysts, non-odontogenic in origin, are soft-tissue lesions of the upper jaw, are derived from nasolacrimal canal epithelium, and are mostly unilateral but sometimes bilateral. Another theory about its etiology is that it occurs because of embryonic fissure cysts. These lesions are thought to be developmental. They can cause swelling and nasal obstruction in the upper lip, alar area, and palate. In this case report, we discuss the role of nasoalveolar cysts in nasal obstruction and how they can be bilateral. A 31-year-old female patient visited our clinic with complaints of nasal obstruction and swelling in front of the nose for 2 years. An anterior rhinoscopic examination revealed a mass and stenosis in both nasal vestibules. Computed tomography revealed a mass-like nasoalveolar cyst in the inferior alar region. Under general anesthesia, a 1-cm mass from the right side and a 2-cm mass from the left side were excised, which were pathologically confirmed as nasoalveolar cysts. Nasoalveolar lesions are rare and mostly unilateral. Bilateral nasoalveolar cysts should be considered in the differential diagnosis of nasal obstruction.Öğe Boyun travması: migrate yabancı cisim(2019) Taş, Burak Mustafa; Şimşek, Gökce; Daphan, Çağatay; Öğden, Mustafa; Gültekin, Yıldırım; Kılıç, RahmiBoyunda yabancı cisim olguları iyatrojenik veya travmatik olabilirler. Ateşli silah yaralanmaları, kesici-delici alet yaralanmaları ile oluşan olgular bunlara örnek gösterilebilir. Büyük arter ve venler, trakea ve nöral yapılar hasara uğrayabilir. Yabancı cismin boyun yapıları ve fasiyaları içerisinde migrate olması nadir ancak beklenen bir durumdur. Bu yüzden yabancı cisimler beklenmedik yerlerde bulunabilir. Bizim olgumuzda 37 yaşında erkek hasta boyunda birçok kesi ve yabancı cisim nedeniyle tarafımıza danışıldı. Hastanın radyolojik görüntülemesinde servikal vertebra anteriorunda yabancı cisim izlendi ve acil ameliyata alındı. Migrate olan yabancı cisim operasyon sonrasında hastanın nazofarenksinde bulundu ve çıkarıldı. Kulak-Burun-Boğaz hekimliği pratiğinde karşımıza çıkabilecek olan boyunda yabancı cisimlere vital yapılara yakınlığı nedeniyle dikkat edilmelidir.Öğe Effect of peritonsillar prilocaine infiltration on post-tonsillectomy pain in pediatric population(Cukurova Univ, Fac Medicine, 2021) Taş, Burak Mustafa; Erden, Burak; Şimşek, GökçePurpose: This study aims to evaluate the efficacy of peritonsillar prilocaine in post-tonsillectomy pain by using the Visual Analog Scale (VAS). Materials and Methods: A total of 40 pediatric patients were included in this study. There were 20 patients in the prilocaine group (Group 1) and 20 patients in the control group (Group 2). In Group 1, peritonsillar prilocaine infiltration was performed. In Group 2, peritonsillar saline infiltration was performed. VAS scores of at the postoperative 1st, 4th, 12th and 24th hours and on the 2nd, 3rd, 4th, 5th, 6th and 7th days were evaluated. In addition, the presence of nausea and vomiting and the number of additional doses of intravenous paracetamol administered in the first 24 hours were evaluated. Results: When the groups were compared, a significant reduction in post-tonsillectomy pain was observed in the prilocaine group at the 1st, 4th and 12th hours compared to the control group. There was no significant difference between the two groups in other scores. There was no significant difference between the groups for nausea and vomiting and consumption of paracetamol values. Conclusion: Peritonsillar prilocaine infiltration was effective in post-tonsillectomy pain at the 1st, 4th and 12th hours postoperatively. Thus, peritonsillar prilocaine infiltration can be used in post-tonsillectomy pain because it is fast and effective.Öğe The Epidermoid Cyst Containing Free Teeth in The Maxillary Sinus(2018) Taş, Burak Mustafa; Şimşek, Gökce; Akay, Neşet; İnal, Mikail; Kılıç, RahmiEpidermoid cysts (EC) are the most common tumors of the skin. They are usually asymptomatic and small-sized. They are more common at young ages. They grow slowly and are painless. The wall of EC is covered with epidermis-like epithelium. EC are rarely seen in sinuses. In our case, a 16-year-old female presented with complaints of swelling and headache that started from the left eye and extended to the upper lip. A biopsy was performed at another hospital of the patient who had previously received medical treatment but had no complaints. A cystic mass containing teeth was observed in the left maxillary sinus on imaging. The cystic mass was excised along with the wall. Pathological results supported the diagnosis of EC. Treatment of EC are surgical and recurrence rates are low. Although many masses are observed in the sinonasal region, epidermoid cysts are rare. It is important to distinguish epidermoid cysts from malignant masses that exhibit expansile growth characteristics. Keywords: Headache, epidermoid cyst, maxillary sinusÖğe EVALUATION OF THE EFFECTIVENESS OF ALPHA LIPOIC ACID IN THE TREATMENT OF BELL'S PALSY(2022) Taş, Burak Mustafa; Şimşek, Gökce; Okumuş, Müyesser; Tozar, MesutObjective: This study aims to evaluate the efficacy of alpha-lipoic acid in the treatment of Bell’s palsy by using the House-Brackmann grading system and electromyography.Material and Methods: A total of 33 patients were included in this retrospective study. Patients were divided into two groups. Group 1 included 18 patients who received 300 mg daily alpha-lipoic acid in addition to Bell’s palsy treatment. Group 2 included 15 patients who only received Bell’s palsy treatment. House-Brackmann grading score at admission, 21st day and at 3rd month were noted in both groups. The results of electromyography performed at 21st day were also scanned. Patients were classified as good prognosis (neuropraxia) and poor prognosis (axonotmesis and neurotmesis) according to electromyography results. The two groups were compared according to House-Brackmann grades and electromyography results.Results: Group 1 consisted of 10 women and 8 men, while Group 2 consisted of 6 women and 9 men. There was no difference between the two groups according to whether Bell’s palsy was on the right or left side. House-Brackmann grading score of the groups at 21st day and 3rd month were significantly lower than House-Brackmann grading score at admission. There was no significant difference between the two groups according to House-Brackmann grades. There was no difference between the groups in terms of compound muscle action potential ratio and prognosis.Conclusion: Although alpha-lipoic acid is used for nerve regeneration in various diseases, it did not demonstrate a significant effect on Bell’s palsy treatment in our study.Öğe Idiopathic Orbital Inflammatory Syndrome: Pseudotumor Orbita(2018) Taş, Burak Mustafa; Şimşek, Gökce; Onaran, Zafer; Burulday, Veysel; Kılıç, RahmiThe idiopathic orbital inflammatory syndrome (pseudotumor orbita) is an unexplained disease that mimicsthe complications of acute rhinosinusitis. Intense polymorphic lymphoid infiltration develops with inflammation. The masses in the orbita can be seen by 5% to 8%. It can cause nonspecific orbital symptoms, such as proptosis and swelling on eyelids. In our case, the patients presented to the eye outpatient clinic with swelling complaint and acute atopic conjunctivitis treatment was initiated but the patients who did not regression complaints were submitted. The patient’s magnetic resonance imaging (MRI) showed bilateral lateral rectus muscle thickening. Idiopathic orbital inflammatory syndrome (pseudotumor orbita) responded to the steroid treatment. Idiopathic orbital inflammatory syndrome (pseudotumor orbita) is benign, but can be confusedwith sinusitis complications with high morbidity and mortality.Öğe Inadvertent Injection of Sodium Hypochlorite to Oral Mucosa(2019) Akay, Neşet; Şimşek, Gökce; Taş, Burak Mustafa; Kılıç, RahmiIt is important to carefully use sodium hypochloride(NaOCI) in its clinical applications. Non-careful use of cytotoxic agents(NaOCI,etg) may cause serious complications. In this case report, a treatment approach to paresthesia and tissue necrosis after inadvertent injection of 1% NaOCl solution into oral mucosa is presented.. Pain, edema, loss of sensation, redness on the cheek, and difficulty in swallowing was seemed during the patient’s clinical examination. The patient was experiencing severe pain and a burning sensation during injection. The patient was administered intraoral drugs,such as antibiotics (amoxicillin 1000 mg two times per a day for two week),alpha lipoic acid (300 mg one times per a day for one mounth), and debridement of oral mucousa .Consequently, re-epithelialization of necrotic tissue was observed in the 3rd month. All symptoms disappeared completely in the 6th month.Öğe Radiological Evaluation of the Effect of Laryngopharyngeal Reflux on the Thickness of Inferior Turbinate, Maxillary Sinus Mucosa and Nasal Septal Body(Springer India, 2024) Taş, Burak Mustafa; Sarıkaya, Pelin Zeynep Bekin; Şencan, Ziya; Cömert, Ela; Muluk, Nuray BayarBackground We investigated the relationship between Laryngopharyngeal Reflux (LPR) and maxillary sinus mucosal thickness (MSMT), inferior turbinate mucosal thickness (ITMT), inferior turbinate width (ITW) and nasal septal body thickness (NSBT), which can be signs of chronic rhinosinusitis and allergic rhinitis.Methods The study, which included 87 patients, was designed as two groups. While 42 of the patients were included in the Laryngopharyngeal Reflux group, 45 were included in the control group. Age and gender information of the patients were noted. MSMT, ITMT, ITW and NSBT values were measured in patients who had Paranasal Sinus Computed Tomography. MSMT, ITMT and ITW were measured as right and left. Both groups were evaluated in terms of these values.Results Right ITMT, bilateral ITW and MSMT values were found to be significantly higher in the LPR group than in the control group (p < 0.05). MSMT values were higher in males (p < 0.05). The left-ITT and NSBT values were not significantly different between the LPR group and the control group, but both values were higher in the LPR group than in the control group (p > 0.05). In the LPR group, there were positive correlations between ITMT and ITW values of the right side; and left side separately (p < 0.05).Conclusion It has been shown that Laryngopharyngeal Reflux increases maxillary sinus mucosal thickness, inferior turbinate thickness and width, and nasal septal body thickness, which can be signs of chronic rhinosinusitis and allergic rhinitis. The negative effects of LPR on nasal and paranasal mucosa and structures were demonstrated in this study.Öğe Role of Microplastics in Chronic Rhinosinusitis Without Nasal Polyps(Wiley, 2024) Taş, Burak Mustafa; Tuna, Ayşegül; Kankılıç, Gökben Başaran; Koçak, Furkan Melih; Sencan, Ziya; Cömert, Ela; Bayar Muluk, NurayObjective: We aimed to examine the relationship between chronic rhinosinusitis without nasal polyps and microplastics. Methods: A total of 80 patients participated in this prospectively planned study. The patients were divided into two groups. Group 1 had 50 patients with chronic rhinosinusitis without nasal polyps, whereas Group 2 had 30 healthy volunteers. The age and gender of the participants were noted. Nose Obstruction Symptom Evaluation questionnaire was applied to the patients. The patients performed nasal lavage with saline. Microplastics were examined in the collected nasal lavage fluids, and their numbers were noted. The groups were compared on these values. Results: The mean age was 38.06 +/- 14.15 years in the chronic rhinosinusitis group without nasal polyps and 33.60 +/- 11.68 years in the control group. There was no significant difference between the groups in terms of age and gender. There was a significant difference in the number of microplastics between the chronic rhinosinusitis group without nasal polyps and the control group (p < 0.001). Microplastics were detected in all participants. Conclusions: We found more microplastics in patients with chronic rhinosinusitis without nasal polyps. According to this result, we can say that there may be a relationship between chronic rhinosinusitis and microplastics.Öğe Sisplatin Ototoksisitesi(2017) Taş, Burak Mustafa; Şimşek, GökçeOtotoksisite çeşitli ilaçlar ve kimyasal maddelerin koklea ve vestibüler organda oluşturduğu hücresel dejenerasyon ve fonksiyon bozukluğudur. Sisplatin (Cis-diamindiklorplatinum II), özellikle baş-boyun tümörlerinde, ürogenital sistem, santral sinir sistemi, solunum sistemi ve özefagus kanserleri olmak üzere birçok malign hastalığın tedavisinde, erişkinlerde ve çocuklarda kullanılmakta olan antineoplastik bir ajandır. Sisplatinin nefrotoksisite ve geri dönüşümsüz ototoksisite dışında diğer önemli doz sınırlayıcı yan etkileri nörotoksisite, gastrointestinal sistem ve kemik iliği toksisitesidir. Sisplatin ototoksik etkisini reaktif oksijen ürünleri ve DNA hasarı ile göstermektedir. Sisplatin ototoksisitesinde klinik olarak başlangışta yüksek frekanslarda, sonrasında konuşma sesini de içeren düşük frekanslarda, bilateral, sensorinöral işitme kaybı görülür. Günümüzde sisplatin bağımlı ototoksisiteyi önlemede standart bir tedavi bulunmamaktadır. Bu derlemede sisplatin ototoksisitesinin tanımı, etki mekanizması, güncel tedavi seçenekleri güncel literatür bilgileri eşliğinde tartışılmıştırÖğe Sisplatin ototoksisitesini önlemede intratimpanik steroidlerin etkinliği: Deneysel çalışma(Kırıkkale Üniversitesi, 2017) Taş, Burak Mustafa; Şimşek, GökçeOtotoksisite çeşitli terapötik ajanlar ve kimyasal maddelerle karşılaşma sonucu koklear ve vestibüler organda ortaya çıkan hasarlanmaya verilen genel bir isimdir. İç kulağın çeşitli kimyasal maddelere karşı duyarlılığı yüz yıllardan beri bilinmektedir ve günümüzde de ototoksisite, işitme kaybı ve denge bozukluğuna yol açan önemli bir nedendir. İnsan ve hayvan çalışmalarında sisplatinin stria vaskularis ve Korti organında değişikliklere neden olduğu gösterilmiştir. İlk etki kokleanın bazal kıvrımındaki dış tüylü hücreler (DTH)'dedir ve ilerleyici olarak daha apikaldekiler ve iç tüylü hücreler (ITH) etkilenir. Sisplatin özellikle koklea içerisinde reaktif oksijen türevlerinin oluşumunu artırır. Serbest radikal oluşumu intraseluler glutatyon seviyelerinin azalması ve böylece antioksidan enzim aktivitesindeki değişiklikler sonucu oluşur. Antioksidan defans sistemindeki bozukluk lipit peroksidasyonunda artışa neden olur ve böylece tüylü hücreler, destek hücreleri, stria vaskularis ve adituar sinirlerde apopitozis oluşur. Ototoksitite için odyolojik monitörizasyon ve mümkünse ototoksisiteye neden olan ilacın kesilmesi en temel yaklaşımdır. Birçok çalışmada sisplatin kaynaklı ototoksititeyi engellemek için çeşitli kemoprotektif ajanlar kullanılmıştır. Ancak üzerinde görüş birliğine varılmış ideal bir ilaç henüz bulunmamaktadır. Bizim çalışmamızda sisplatin ototoksisitesinin önlenmesinde intratimpanik steroidlerin etkinliği karşılaştırıldı. Bu çalışmada 32 rat (64 kulak) 4 gruba ayrılarak kullanıldı. 1. Gruba intraperitoneal sisplatin verildi. 2. Gruba metilprednizolon intratimpanik olarak verildikten sonra sisplatin verildi. 3. Gruba deksametazon intratimpanik olarak verildikten sonra sisplatin verildi. 4. Gruba ise %0.9'luk NaCl intratimpanik olarak verildikten sonra sisplatin verildi. Tüm gruplara işlem öncesi ve işlem sonrası ABR ve DPOAE testleri yapıldı. Tedavi öncesi ve sonrası ABR 1, ABR 4, ABR (1-4) intervali ve eşik değerleri ölçüldü. DPOAE testinde ise tedavi öncesi ve sonrası 1416 kHz, 2002 kHz, 2832 kHz, 4004 kHz ve 5652 kHz frekanslarında ölçüm yapıldı. Deksametazon ve Metilprednizolon uygulamalarının sisplatin ototoksisitelerini önlemede önemli etkileri gözlenmiştir.Öğe The effect of maxillary sinus floor elevation with lateral antrostomy approach on nasal mucociliary functions(Springer, 2024) Akay, Neşet; Altay, Berkan; Taş, Burak Mustafa; Altuntop, İremPurposeIt is aimed to evaluate the effect of maxillary sinus elevation with lateral antrostomy approach on mucociliary functions using the saccharin test.MethodsThe study was planned prospectively. 29 patients who underwent maxillary sinus elevation were included in the study. The age and gender information of the patients were noted. Saccharin test was performed in the nasal cavity on the operated side. Mucociliary functions were evaluated with the results of the saccharin test performed before the operation and the saccharin test results at the 1st week, 1st month, and 3rd month postoperatively. Comparisons were made with these values.ResultsThe mean age of the patients was 42.10 +/- 4.99 years. Of the patients, 14 (48.3%) were female and 15 (51.7%) were male. Preoperative saccharine test results were found to be significantly lower than the postoperative values. As the postoperative recovery period increased, a significant decrease was observed in the saccharin test results. However, preoperative values were within normal limits, while postoperative values were above the normal range.ConclusionsIn our study, it was observed that mucociliary functions improved as the postoperative period increased in patients who underwent maxillary sinus elevation, but were still above normal limits.Öğe Wegener Granulomatosis: Operated Nasal Septal Perforation(2018) Taş, Burak Mustafa; Şimşek, Gökce; Balcı, Mahi; Akay, Hatice Güzelküçük; Kılıç, RahmiWegener’s granulomatosis is an idiopathic necrotizing granulatous vasculitis that can hold small and medium arteries, upper respiratory tract, lung and kidney involvement. It’s an ANCA associated vasculitis. c-ANCA positivity is considered very sensitive. In our case, a 40-year-old female patient was admitted to our hospital with complaints of nasal bleeding and crusting. The patient was operated due to idiopathic nasal septal perforation, was seen saddle nose deformity and 3x4 cm in size perforation in anterior septum and 1x2 cm in size perforation in posterior septum. Nasal biopsies of the patient with C-ANCA positivity were taken and the result of pathology came in harmony with Wegener’s granulomatosis. The patient was directed to the related clinic for the treatment of Wegener’s granulomatosis. Wegener Granulomatosis, which enters the diagnosis of idiopathic nasal septal perforation, is a disease that should be kept in mind.
