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Öğe Bilateral non-arteritic anterior ischemic optic neuropathy following second-trimester spontaneous abortion-related haemorrhage(Elsevier Sci Ltd, 2012) Onaran, Zafer; Tan, Funda Uysal; Yilmazbas, Pelin; Onaran, YükselBilateral anterior ischemic optic neuropathy is a rare complication of massive haemorrhage and related hypotension and anaemia in young individuals. We report a 34-year-old woman with bilateral non-arteritic ischemic optic neuropathy (NAION) after a massive spontaneous abortion-related haemorrhage who presented with sudden painless visual loss in her left eye. Visual acuity was 20/20 in the right eye with only hand motion discernible in the left eye. There was a left relative afferent papillary defect (RAPD). Fundus examination revealed bilateral swollen, hyperaemic optic discs and nerve fiber layer haemorrhages. Brain MRI and magnetic resonance venography were normal. The diagnosis of bilateral NAION was made and intravenous pulse corticosteroid therapy (1000 mg/day) was administered for three days. On the sixth clay, optic disc oedema regressed bilaterally and on the third week, the visual acuity improved to 20/80 in the left eye. The visual field showed only a small spared area in the nasal region, and persistent RAPD was present. After two months, fundus examination showed a small and crowded optic disc on the right and a pale optic disc on the left. Severe acute haemorrhage is an important risk factor for NAION in healthy young individuals. In addition to correction of hypotension and anaemia, intravenous high dose corticosteroid might be beneficial for treatment. (C) 2012 Elsevier Ltd. All rights reserved.Öğe Bilateral Optic Neuritis After Influenza Vaccination(Informa Healthcare, 2010) Tan, Funda Uysal; Akarsu, Cengiz; Gullu, Reyhan; Kansu, TulayOptic neuritis is a rare complication of vaccination. We report a 55-year-old woman who presented with bilateral optic neuritis following influenza vaccination. The patient has typical features of acute optic neuritis with acute visual loss, periocular pain, visual defects, full recovery of vision after 6 months, and the absence of deterioration after withdrawal of corticosteroids. Considering the absence of oligoclonal bands in the cerebrospinal fluid analysis and the nonexistence of lesions resembling multiple sclerosis (MS) in cranial magnetic resonance imaging, the case at present does not appear to be associated with MS.Öğe DEPRESSION AND ANXIETY IN PATIENTS WITH MIGRAINE AND TENSION-TYPE HEADACHE(Gazi Univ, Fac Med, 2005) Tan, Funda Uysal; Ozen, Nurper Erberk; Kazezoglu, Saziye; Kokoglu, Fatma; Boratay, CumhurPurpose: The identifi cation of headache patients who are at risk for psychiatric comorbidity is an important quality of life and prognostic issue. The purpose of this study was to assess psychiatric comorbidity in TTH and migraine patients. Materials and Methods: The study group included 95 (75 female, 20 male) patients diagnosed with either migraine or TTH. All patients were requested to fi ll out a 44-item symptom list constructed according to DSM-IV diagnostic criteria for depression and anxiety disorders and to complete the Beck Depression Inventory (BDI) and Spielberger State-trait Anxiety Inventory (STAI). After that all patients were evaluated for the presence of psychiatric disorders according to DSM-IV criteria. Results: Fifty-one (53.7%) patients had migraine while 44 (46.3%) had TTH and their mean ages were 32.77 +/- 7.8 and 30.32 +/- 9.4 years, respectively (p=0.11). The overall intensity levels of symptoms related to depression and anxiety were similar in both migraine and TTH patients. However, reduced libido (p=0.02), slowness (p=0.04) and nausea (p=0.003) were more intense in migraine patients. The mean BDI, SAI and TAI scores were elevated to the pathologic range in both migraine and TTH patients despite the absence of a signifi cant difference between the groups. The incidences of depression, anxiety and depression+anxiety were 37.3%, 15.7% and 9.8%, respectively, in migraine patients and 43.2%, 9.1% and 6.8%, respectively, in TTH patients (p=0.92). Conclusion: Depression and anxiety disorders are common and generally similar in extent and distribution in migraine and TTH patients.Öğe Depression and anxiety in patients with migrane and tension-type headache(2005) Tan, Funda Uysal; Özen, Erberk Nurperi; Kazezoğlu, Şaziye; Kökoğlu, Fatma; Boratay, CumhurAmaç: Başağrısı olan olgularda psikiyatrik komorbidite riskinin belirlenmesi olguların yaşam kalitesi ve prognostik açıdan büyük önem taşımaktadır. Bu çalışmada migren ve gerilim tipi başağnsı (GTBA) olan hastalarda psikiyatrik bozukluklar araştırılmıştır. Hastalar ve Yöntem: Kırıkkale Üniversitesi Tıp Fakültesi Nöroloji Ana-bilim dalında ayrıntılı anamnez ve nörolojik muayene sonunda uluslararası başağnsı kriterlerine göre migren ve gerilim tipi başağnsı tanısı alan 75 kadın, 20 erkek toplam 95 hasta çalışmaya alındı. Tüm hastalara DSM-IV'de depresyon ve anksiyete bozuklukları tanı kriterleri temel alınarak hazırlanmış kırk bir soruluk bir semptom sorgulama formu verildi. Bununla birlikte hastalara Beck depresyon ölçeği (BDÖ)ve durumluluk ve sürekli anksiyete ölçeği(STAI-t ve STAI-s) (Stait and trait) uygulandı. Formların tamamlanmasını takiben olgulara psikiyatrik değerlendirme yapıldı. Bulgular: Çalışma grubunu oluşturan olguların 51 'inde (%53.7) migren ve 44'ünde (%46.3) GTBA mevcut olup ortalama yaşlan sırasıyla 32.77D7.8 ve 30.32D9.4 yıl bulundu (p0.11.). Her iki grupta semptomların şiddeti genel olarak benzer olmasına karşın migrcnli olgularda libido azalması (p0.02), yavaşlık (p0.04) ve bulantı'nın (p0.003) daha ağır olduğu görüldü. Gruplar arasında fark olmamakla beraber hem migren hem GTBA'lı olgularda BDÖ, STAI-t ve STAI-s skorlarının patolojik derecede yüksek olduğu belirlendi. Psikiyatrik değerlendirme sonrasında migrenli olguların %37.3'ünde depresyon, %15.7'sinde anksiyete, %9.8'inde depresyonanksiyete birlikte saptanırken GTBA olguların %43.2'sinde depresyon, %9.1'inde ankziyete, %6.8'inde depresyonanksiyete birlikte bulunuyordu (p0.92) Sonuç: Bu çalışmada hem migren hem GTBA'sinda yüksek oranda ve benzer şiddetle depresyon ve anksiyete komorbiditesi olduğu sonucuna varılmıştır.Öğe Gabapentin treatment in notalgia paresthetica: a preliminary report(Wiley, 2020) Tan, Funda Uysal; Koc, Rabia Soylu; Durmaz, Emel Erkek Ozturk; Akyurek, Fatma Tuncez…Öğe Migraine-like headache in cerebral venous sinus thrombosis(Termedia Publishing House Ltd, 2015) Tan, Funda Uysal; Tellioglu, Serdar; Koc, Rabia Soylu; Leventoglu, AlevA 20-year-old female, university student presented with severe, throbbing, unilateral headache, nausea and vomiting that started 2 days ago. The pain was aggravated with physical activity and she had photophobia. She had been taking contraceptive pills due to polycystic ovary for 3 months. Cranial computed tomography was uninformative and she was considered to have the first attack of migraine. She did not benefit from triptan treatment and as the duration of pain exceeded 72 h further imaging was done. Cranial MRI and MR venography revealed a central filling defect and lack of flow in the left sigmoid sinus caused by venous sinus thrombosis. In search for precipitating factors besides the use of contraceptive pills, plasma protein C activity was found to be depressed (42%, normal 70-140%), homocystein was minimally elevated (12.7 mu mol/L, normal 0-12 mu mol/L) and anti-cardiolipin IgM antibody was close to the upper limit. (C) 2015 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.Öğe NEUROGENIC BLADDER INDUCED BY CHRONIC ALCOHOL ABUSE: A CASE REPORT(2023) Keles, Hatıce; Canver, Burak; Başar, Halil; Tan, Funda UysalLong-term alcohol consumption may produce wide-ranging effects on the autonomic and peripheral nervous systems like almost all body tissues, but the pathogenesis is still under debate. We presented an extremely rare case of autonomic neurogenic bladder with bilateral hydroureteronephrosis in a male patient describing progressive abdominal distension over a year that is most significant in the last 4 months following alcohol withdrawal after a long duration of alcohol abuse. Chronic alcoholism should be considered in the differential diagnosis of a neurogenic bladder, which may be caused by autonomic dysfunction due to chronic alcohol abuse and may be precipitated by alcohol withdrawal.Öğe Post-thymectomy, seronegative myasthenia gravis(Taylor & Francis Inc, 2008) Tan, Funda Uysal; Kansu, Tulay; Akarsu, CengizPatients with thymoma associated myasthenia gravis (MG) usually present with severe disease unresponsive to usual treatment and almost all have antibodies against acetylcholine receptors (AChR). We like to present a case of post-thymectomy, seronegative MG. A 55-year-old man was referred with horizontal diplopia and abduction deficit in the right eye two years after he had thymectomy for a thymoma. Single-fiber electromyography was diagnostic for MG and AChR titer was undetectable. Ocular signs did not response to pyridostigmine, prednisolone and immunoglobulin treatments and the patient also suffered from proximal weakness and pain in the extremities. Cyclosporine-A was started and the initial response was favorable with a decrease in general weakness.Öğe Retinal nerve fiber layer thickness is unaffected in migraine patients(Wiley, 2005) Tan, Funda Uysal; Akarsu, Cengiz; Güllü, ReyhanObjectives - To search for possible Structural effects of migraine on the retina. Materials and methods - The study group included 39 consecutive migraine patients, 15 with visual aura and 24 without aura, and 25 healthy subjects as the control group. Scanning laser polarimetry was used to measure and compare retinal nerve fiber layer (RNFL) thickness between migraine and control groups. Results - The mean age of the patients and the control group were 35.64 +/- 8.3 and 35.96 +/- 9.14 years. respectively (P = 0.92) and the mean duration of migraine in patients with aura and without aura as 4.4 +/- 2.9 and 5.3 +/- 4.3 years, respectively (P = 0.68). Parameters related to RNFL thickness were found to be similar (P > 0.001) in migraine and control subjects. After examining the whole patient group migraine patients with and without aura were compared to each other and the control group Individually for a - RNFL thickness parameters. Briefly no statistical difference was found for any of the test parameters between migraine patients with aura. without aura and controls (P > 0.001). Conclusion - Retinal nerve fiber layer thickness was found to be unaffected in migraine patients.Öğe Use of botulinum toxin type a for the treatment of masseteric muscle hypertrophy(B C Decker Inc, 2006) Arıkan, Osman Kürşat; Tan, Funda Uysal; Kendi, Tuba; Koç, CanWe investigated the effectiveness of botulinum toxin A intramuscular injection for the management of masseteric muscle hypertrophy. Five patients with masseteric muscle hypertrophy were treated with botulinum toxin A (Dysport, Beaufour Ipsen, France). Clinical photographs were obtained before and between 3 and 6 months after application. Four patients are pleased with their present facial appearance. However, one patient reported mild discomfort about his appearance. Neither local nor general adverse effects were noted. Botulinum toxin A is a safe, easy-to-use, and effective nonsurgical option in the management of masseteric muscle hypertrophy. Its use is associated with a high degree of patient and physician satisfaction.
