Yazar "Tas, Burak Mustafa" seçeneğine göre listele

Listeleniyor 1 - 8 / 8
  • [ X ]
    Öğe
    Comparison of Intratympanic Oxytocin and Dexamethasone in Cisplatin Ototoxicity: An Experimental Study
    (Springer India, 2024) Tas, Burak Mustafa; Ozel, Goekce; Azman, Musa; cakmak Karaer, Isil; Kilic, Rahmi
    Although it is widely used, there is still no valid treatment for ototoxicity caused by the antineoplastic drug cisplatin. In this study, we aimed to investigate the efficacy of intratympanic resveratrol and intratympanic dexamethasone treatment in cisplatin-induced ototoxicity. We also compared intratympanic atosiban (oxytocin antagonist) and oxytocin in cisplatin ototoxicity. In this study, 30 rats (60 ears) were used by separating into 5 groups. Cisplatin, oxytocin, dexamethasone, atosiban and 0.9% NaCl were administered intraperitoneally to all groups separately. Auditory Brainstem Response and Distortion Product Otoacoustic Emission tests were performed on all groups before and 72 h after the procedure. Pre-treatment values were higher than post-treatment values in all groups (p < 0.001). There was no significant prolongation of the post-treatment Auditory Brainstem Response I-IV interval in the oxytocin and dexamethasone groups (p > 0.05). There was no significant decrease in the frequencies of 2832 and 4004 after treatment in the oxytocin and dexamethasone group compared to pre-treatment in Distortion Product Otoacoustic Emission. As a result, it has been shown that intratympanic oxytocin may be an option that can be used in the treatment, although it is not as effective as dexamethasone in preventing cisplatin ototoxicity.
  • [ X ]
    Öğe
    Comparison of nasal functional outcomes of let down rhinoplasty and open technical rhinoplasty using spreader graft
    (Springer, 2021) Tas, Burak Mustafa; Erden, Burak
    Purpose This study aimed to compare open technique rhinoplasty with spreader graft and Let Down rhinoplasty using Nasal Symptom Obstruction Evaluation (NOSE), Sinonasal Outcome Test-22 (SNOT-22), and Visual Analog Scale (VAS). Materials and methods A total of 50 patients were included in the study. Patients with a hump greater than 4 mm and mild septal deviation participated in the study. The patients were divided into two groups. Group 1 consisted of 26 patients who underwent Let Down rhinoplasty, while Group 2 consisted of 24 patients who underwent open rhinoplasty with spreader graft. NOSE, SNOT-22, and VAS scales were completed by both groups preoperatively and postoperatively. Results There was no significant difference between the groups in terms of age and gender. Postoperative values of scales were significantly lower than preoperative values in Group 1 (p < 0.001). In Group 2, postoperative values were significantly lower than preoperative values (p < 0.001). There was no significant difference between the two groups according to NOSE, SNOT-22 and VAS scores. Conclusion According to the comparison of scale scores, both Let Down rhinoplasty and open technique rhinoplasty using spreader graft improved nasal functional results such as nasal obstruction.
  • Küçük Resim
    Öğe
    Comparison of the protective efficacy between intratympanic dexamethasone and resveratrol treatments against cisplatin-induced ototoxicity: an experimental study
    (Springer, 2019) Simsek, Goekce; Tas, Burak Mustafa; Muluk, Nuray Bayar; Azman, Musa; Kilic, Rahmi
    Purpose The main aim of this study was to compare the efficacy of intratympanic administration of dexamethasone and resveratrol in preventing cisplatin ototoxicity by measuring acoustic brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Methods Forty rats (80 ears) were divided into five groups. Cisplatin was administered intraperitoneally to the first group (n = 8). Group 2 (n = 8) received cisplatin after resveratrol had been administered intratympanically. Group 3 (n = 8) received cisplatin after dexamethasone had been administered intratympanically. Group 4 (n = 8) received cisplatin after sodium chloride (NaCl) had been given intratympanically. Group 5 (n = 8) received cisplatin after dimethylsulfoxide (DMSO) had been given intratympanically. ABR and DPOAE tests were performed on all groups before and 72 h after the procedure. Results ABR threshold values in rats that received dexamethasone and resveratrol were found to be less affected than those observed in the other post-cisplatin groups. ABR-IV and ABR-I-IV interval values were significantly reduced in rats that had been given dexamethasone and resveratrol compared to the other groups. After cisplatin treatment, otoacoustic emission (OAE) amplitudes were significantly decreased in Groups 1, 4, and 5 for all frequencies, while OAE values were sustained in the resveratrol and dexamethasone groups (Groups 2 and 3). At OAE frequency 5652, dexamethasone was more significantly associated with protective than resveratrol was, while no significant difference was found between the two groups at other OAE frequencies. Conclusion In conclusion, intratympanic dexamethasone and intratympanic resveratrol treatments may provide a significant protection against cisplatin-induced ototoxicity.
  • [ X ]
    Öğe
    Effect of peritonsillar prilocaine infiltration on post-tonsillectomy pain in pediatric population
    (Cukurova Univ, Fac Medicine, 2021) Tas, Burak Mustafa; Erden, Burak; Simsek, Gokce
    Purpose: This study aims to evaluate the efficacy of peritonsillar prilocaine in post-tonsillectomy pain by using the Visual Analog Scale (VAS). Materials and Methods: A total of 40 pediatric patients were included in this study. There were 20 patients in the prilocaine group (Group 1) and 20 patients in the control group (Group 2). In Group 1, peritonsillar prilocaine infiltration was performed. In Group 2, peritonsillar saline infiltration was performed. VAS scores of at the postoperative 1st, 4th, 12th and 24th hours and on the 2nd, 3rd, 4th, 5th, 6th and 7th days were evaluated. In addition, the presence of nausea and vomiting and the number of additional doses of intravenous paracetamol administered in the first 24 hours were evaluated. Results: When the groups were compared, a significant reduction in post-tonsillectomy pain was observed in the prilocaine group at the 1st, 4th and 12th hours compared to the control group. There was no significant difference between the two groups in other scores. There was no significant difference between the groups for nausea and vomiting and consumption of paracetamol values. Conclusion: Peritonsillar prilocaine infiltration was effective in post-tonsillectomy pain at the 1st, 4th and 12th hours postoperatively. Thus, peritonsillar prilocaine infiltration can be used in post-tonsillectomy pain because it is fast and effective.
  • [ X ]
    Öğe
    Evaluation of Clinical Features and Olfactory Functions in COVID-19: A Multicentre Study
    (Springernature, 2023) Tas, Burak Mustafa; Alpaydin, Turgay; Akcali, Sinem; Kaygusuz, Sedat; Erol, Oezlem Ozluk; Sencan, Ziya; Comert, Ela
    IntroductionCoronavirus Disease-2019 (COVID-19) causes olfactory loss one of the initial diagnostic criteria. The brief smell identification test (BSIT) is an objective test frequently used in olfactory dysfunction. This study aimed to observe the changes in olfactory functions and clinical features in a short time in COVID-19.MethodsIn this prospective study involving 64 patients, the BSIT was performed at two different times; at the time of first application and on the 14th day. Demographic features, laboratory findings, body mass index (BMI), blood oxygen saturation values (SpO2), complaints at first admission, fever, follow-up place, and treatment schemes were noted.ResultsThere was a significant difference between the BSIT scores at the first admission and when the polymerase chain reaction (PCR) became negative on the 14th day (p<0.001). Low oxygen saturation values at first admission were associated with low BSIT scores. No relationship was found between olfactory functions and complaints at admission, fever, follow-up place, and treatment schemes. ConclusionAs a result, negative effects of COVID-19 on olfactory functions have been demonstrated even in the short follow-up period. In addition, low saturation values at first admission were associated with low BSIT scores.
  • [ X ]
    Öğe
    Radiological Evaluation of the Effect of Laryngopharyngeal Reflux on the Thickness of Inferior Turbinate, Maxillary Sinus Mucosa and Nasal Septal Body
    (Springer India, 2024) Tas, Burak Mustafa; Sarikaya, Pelin Zeynep Bekin; Sencan, Ziya; Comert, Ela; Muluk, Nuray Bayar
    Background We investigated the relationship between Laryngopharyngeal Reflux (LPR) and maxillary sinus mucosal thickness (MSMT), inferior turbinate mucosal thickness (ITMT), inferior turbinate width (ITW) and nasal septal body thickness (NSBT), which can be signs of chronic rhinosinusitis and allergic rhinitis.Methods The study, which included 87 patients, was designed as two groups. While 42 of the patients were included in the Laryngopharyngeal Reflux group, 45 were included in the control group. Age and gender information of the patients were noted. MSMT, ITMT, ITW and NSBT values were measured in patients who had Paranasal Sinus Computed Tomography. MSMT, ITMT and ITW were measured as right and left. Both groups were evaluated in terms of these values.Results Right ITMT, bilateral ITW and MSMT values were found to be significantly higher in the LPR group than in the control group (p < 0.05). MSMT values were higher in males (p < 0.05). The left-ITT and NSBT values were not significantly different between the LPR group and the control group, but both values were higher in the LPR group than in the control group (p > 0.05). In the LPR group, there were positive correlations between ITMT and ITW values of the right side; and left side separately (p < 0.05).Conclusion It has been shown that Laryngopharyngeal Reflux increases maxillary sinus mucosal thickness, inferior turbinate thickness and width, and nasal septal body thickness, which can be signs of chronic rhinosinusitis and allergic rhinitis. The negative effects of LPR on nasal and paranasal mucosa and structures were demonstrated in this study.
  • [ X ]
    Öğe
    Role of Microplastics in Chronic Rhinosinusitis Without Nasal Polyps
    (Wiley, 2024) Tas, Burak Mustafa; Tuna, Aysegul; Kankilic, Goekben Basaran; Kocak, Furkan Melih; Sencan, Ziya; Comert, Ela; Bayar Muluk, Nuray
    Objective: We aimed to examine the relationship between chronic rhinosinusitis without nasal polyps and microplastics. Methods: A total of 80 patients participated in this prospectively planned study. The patients were divided into two groups. Group 1 had 50 patients with chronic rhinosinusitis without nasal polyps, whereas Group 2 had 30 healthy volunteers. The age and gender of the participants were noted. Nose Obstruction Symptom Evaluation questionnaire was applied to the patients. The patients performed nasal lavage with saline. Microplastics were examined in the collected nasal lavage fluids, and their numbers were noted. The groups were compared on these values. Results: The mean age was 38.06 +/- 14.15 years in the chronic rhinosinusitis group without nasal polyps and 33.60 +/- 11.68 years in the control group. There was no significant difference between the groups in terms of age and gender. There was a significant difference in the number of microplastics between the chronic rhinosinusitis group without nasal polyps and the control group (p < 0.001). Microplastics were detected in all participants. Conclusions: We found more microplastics in patients with chronic rhinosinusitis without nasal polyps. According to this result, we can say that there may be a relationship between chronic rhinosinusitis and microplastics.
  • [ X ]
    Öğe
    The effect of maxillary sinus floor elevation with lateral antrostomy approach on nasal mucociliary functions
    (Springer, 2024) Akay, Neset; Altay, Berkan; Tas, Burak Mustafa; Altuntop, Irem
    PurposeIt is aimed to evaluate the effect of maxillary sinus elevation with lateral antrostomy approach on mucociliary functions using the saccharin test.MethodsThe study was planned prospectively. 29 patients who underwent maxillary sinus elevation were included in the study. The age and gender information of the patients were noted. Saccharin test was performed in the nasal cavity on the operated side. Mucociliary functions were evaluated with the results of the saccharin test performed before the operation and the saccharin test results at the 1st week, 1st month, and 3rd month postoperatively. Comparisons were made with these values.ResultsThe mean age of the patients was 42.10 +/- 4.99 years. Of the patients, 14 (48.3%) were female and 15 (51.7%) were male. Preoperative saccharine test results were found to be significantly lower than the postoperative values. As the postoperative recovery period increased, a significant decrease was observed in the saccharin test results. However, preoperative values were within normal limits, while postoperative values were above the normal range.ConclusionsIn our study, it was observed that mucociliary functions improved as the postoperative period increased in patients who underwent maxillary sinus elevation, but were still above normal limits.