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    Öğe
    Comparison of the algan hemostatic agent with celox in rat femoral artery bleeding model
    (2021) Bınnetoglu, Kenan; Kumandaş, Ali; Ekici, Hüsamettin; Özbaykuş, Abdullah Canberk; Tiryaki, Mehmet
    The most important reasons of deaths after a trauma are major vascular injury. The effective and speedy control of the hemorrhage is crucial in reducing such deaths. Although many products are being used for this topic, most effective products have not yet been developed currently, and there is an urgent need for effective hemostatic. The aim of this study is to compare the efficacy of Algan hemostatic agent (AHA) with Celox in femoral artery incision model in rats. A total of 28 wistar albino rats divided into 4 equal groups. Experimental femoral artery injury was inflicted. In the control group, saline impregnated gauze was employed. AHA impregnated sponge, AHA powder, and Celox in powder form were utilized in the experimental groups. According to the results, there was no difference in bleeding control between AHA and C (p>0.05). When compared to the control group, AHA and Celox were found to be very effective in bleeding control (p<0.001). This study showed that AHA had a similar effect like Celox in controlling bleeding. Considering other characteristics such as AHA's naturalness, easy applicability and low cost, AHA has given hope as an effective hemostatic agent.
  • Küçük Resim
    Öğe
    Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats
    (Marmara Univ, Fac Medicine, 2019) Midi, Ahmet; Ekici, Husamettin; Kumandas, Ali; Durmus, Omercan; Bodic, Buse; Tiryaki, Mehmet; Yesilada, Erdem
    Objective: Algan hemostatic agent (AHA) is a plant-based hemostatic agent produced in Turkey. Although, there is a great improvement in the hemostatic technologies, more effective hemostatic products are required to be produced. The aim of this study was to demonstrate the efficacy of AHA in a partial splenectomy model in rats. In addition, in this model, postoperative abdominal adhesion was evaluated. Materials and Methods: In this study 5-7 weeks old 64 rats were used. Rats were randomly divided into 8 groups, each consisting of eight rats (4 groups heparinized and 4 groups non-heparinized). Experimental splenectomy was performed and the gauze impregnated with saline was applied to the control group for the hemorrhage control, the gauze impregnated with liquid AHA, gel and powder form of AHA, was applied to the experimental groups. Results: The time to reach complete homeostasis was significantly shorter in all AHA groups compared to the control group. The powder and the gel forms of AHA stopped the bleeding in heparinized and non-heparinized groups in 1 second. The AHA fluid (sponge) form stopped the bleeding in the first application in the control group less than 10 seconds and the second time application was not necessary. The bleeding was able to be controlled in the heparinized control group (saline impregnated sponge) by 55 seconds and in the non-heparinized control group by 38 seconds. Conclusion: This study showed that AHA is a highly effective hemostatic agent, which would be beneficial in controlling hemorrhage.