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Öğe Assessment of the effects of menopause on semicircular canal using the video head impulse test(TAYLOR & FRANCIS INC, 2020) Tulmac, Ozlem Banu; Simsek, GokceThis cross-sectional study included early menopausal and late menopausal women aged between 40 and 60 years to evaluate the effects of menopause on semicircular canal function. A video head impulse test (vHIT) was performed for all subjects. Vestibulo-ocular reflex (VOR) mean gains of each semicircular canal and gain asymmetry were compared between groups. Of the 87 subjects, 37(42.5%) were reproductive age 28(32.5%) were early menopausal and 22(25.3%) were late menopausal patients. VOR gain of semicircular canals or gain asymmetry values did not differ between groups. In postmenopausal women, presence of vasomotor symptoms was associated with higher gain asymmetry of the left anterior-right posterior (LARP) plane (p = .01), and presence of balance problems was associated with lower right anterior (RA) VOR gain (p = .01). In conclusion semicircular canal function in postmenopausal women was similar to that in women of reproductive age. IMPACT STATEMENT What is already known on this subject? During menopause, women face potential risks such as dizziness, balance problems, falls and fractures. Postmenopausal patients were tested with dynamic posturography to measure balance before and after oestrogen treatment, and it was shown that balance problems significantly improved with oestrogen treatment. Healthy vestibular system is one of the components for sustaining normal balance. What do the results of this study add? In postmenopausal women the function of the semicircular canals is normal and the balance deficit in postmenopausal women may not be caused by the vestibular system. In this study changes within normal limits were observed in vestibular system of postmenopausal women. What are the implications of these findings for clinical practice and/or further research? Reported balance deficits might have been due to central origin. Further research to differentiate origin of balance deficits are needed. Specific research on symptomatic postmenopausal patients would reveal more information.Öğe Could erythropoietin reduce the ovarian damage of cisplatin in female rats?(Taylor & Francis Ltd, 2018) Sayan, Cemile Dayangan; Tulmac, Ozlem Banu; Karaca, Gokhan; Ozkan, Zehra Sema; Yalcin, Selim; Devrim, Tuba; Badem, Nermin DindarThe aim of this study is to investigate whether erythropoietin (EPO) can reduce the ovarian damage of cisplatin or not. Thirty, female, Wistar-Albino rats were used in the study. Control group (N=10): Intraperitoneal saline infusion, Cisplatin group (N=10): Intraperitoneal 7mg/kg cisplatin, Cisplatin+EPO group (N=10): Intraperitoneal 7mg/kg cisplatin and subcutaneous 200IU/kg/day EPO. Serum AMH concentrations were measured by enzyme-linked immunosorbent assay kit of AMH. Follicular counts were evaluated according to mean diameter of the follicles. Ovarian damage; including follicular cell degeneration, vascular congestion, hemorrhage, and inflammation was scored histologically using a graduated scale. Posttreatment AMH levels of cisplatin group were significantly lower than control and cisplatin+EPO groups. In cisplatin group, there was a significant decrement in posttreatment AMH level compared to pretreatment AMH level. The total damage score of cisplatin group was significantly higher than scores of control and cisplatin+EPO groups. The mean primordial follicle counts of control and cisplatin+EPO groups were significantly higher than that of cisplatin group (p=.007 and p=.003). The results of this study revealed that EPO administration to cisplatin chemotherapy could ameliorate the ovarian damage. Erythropoietin administration to chemotherapeutic agents might suggest to protect ovarian failure and infertility.Öğe Histological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia model(Turkish Joint Diseases Foundation, 2016) Turker, Mehmet; Aslan, Arif; Cirpar, Meric; Kochai, Alauddin; Tulmac, Ozlem Banu; Balci, MahiObjectives: This study aims to investigate the effects of zoledronate therapy on histological and biomechanical properties of bone healing via a fracture model generated on osteoporotic rat tibiae. Materials and methods: Ovariectomized 40 Wistar-Dawley female rats weighing 300 g to 350 g were used in the study. After one week, 2 IU/g heparin injection was started subcutaneously. After four weeks of daily injections, osteoporosis was ensued proven with bone mineral density measurements. Osteoporotic rats were separated into four equal groups randomly as group A (control), group B (calcium and vitamin D), group C (0.1 mg/kg subcutaneous zoledronic acid), and group D (calcium and vitamin D / 0.1 mg/kg subcutaneous zoledronic acid). Six weeks later, all rats were sacrificed, their tibiae were resected, and histopathologic and biomechanical studies were performed. Results: Group C (30.2 +/- 1 Nm) and group D (33.3 +/- 3 Nm) had significantly higher peak torque values than group A (21.6 +/- 6 Nm) and group B (23.6 +/- 4 Nm) (p=0.007 and p=0.005, respectively). Group C (1.8) and group D (2.0) had higher stiffness values than group A (1.4) and group B (1.7); however, the difference was not statistically significant (p>0.05 for all). Conclusion: According to histopathological and biomechanical test results, single dose zoledronic acid treatment improves fracture healing in an osteoporotic rat fracture model. Orally administered daily calcium and vitamin D treatment had no effect on fracture healing. There was no additional improvement in fracture healing when calcium and vitamin D treatment was added to zoledronic acid treatment. Positive effects of zoledronic acid treatment on osteoporotic fracture healing and callus quality should be shown by future clinical studies.Öğe Ocular blood flow in polycystic ovary syndrome(Wiley, 2015) Ornek, Nurgul; Inal, Mikail; Tulmac, Ozlem Banu; Ozcan-Dag, Zeynep; Ornek, KemalAimThe aim of this study was to evaluate whether the presence of polycystic ovary syndrome (PCOS) alters ocular blood flow parameters. Material and MethodsColor Doppler imaging of the orbital vessels was performed in 41 eyes of 41 patients with PCOS. Forty-eight eyes of 48 age-matched volunteers served as controls. The ophthalmic artery (OA), the central retinal artery and the posterior ciliary artery were examined. Ocular blood flow indices of the peak systolic velocity, diastolic velocity, end-diastolic velocity, systolic/diastolic ratio, resistive index and pulsatility index were computed. ResultsThe peak systolic velocity, diastolic velocity and end-diastolic velocity of the OA, central retinal artery and posterior ciliary artery were significantly increased in PCOS patients in comparison to the controls (all P<0.001). The mean systolic/diastolic ratio, resistive index and pulsatility index of the OA in PCOS patients were significantly decreased (all P<0.05). Ocular blood flow velocity was positively correlated with serum luteinizing hormone, follicle-stimulating hormone and total cholesterol levels. There was a significant negative correlation between serum glucose and insulin levels and ocular blood flow velocity. ConclusionOcular blood flow velocity is increased in PCOS patients and vascular resistance seems to decrease only in the OA.Öğe Prenatal Diagnosis Preferences of Turkish Women and the Association of their Choices with Temperament(Bentham Science Publ Ltd, 2022) Tulmac, Ozlem Banu; Buturak, VisalObjectives: The purpose of this study is to explain which choices Turkish women prefer for prenatal diagnosis more frequently and to find out if there is an association between temperament and decisions through the prenatal diagnostic steps or consistency of decision. Materials and Methods: This is a cross-sectional study on pregnant women who were admitted to our outpatient clinic based on the responses to a self-administered questionnaire at the time of combined test or triple test as the first prenatal screening test. 198 pregnant women completed self-administered questionnaires comprising 131 questions including Temperament Evaluation of Memphis, Pisa, Paris, and San Diego questionnaire (TEMPS-A). Results: Overall, 88.4% of women were willing to learn if there was an anomaly, whereas 4.5% did not, and 7.5% were uncertain. Of the included patients, 87.9% would decide on the screening tests to be performed, 23.2% had a positive attitude on diagnostic tests, and only 13.1% were in favour of termination. No association was found between the temperament scores and positive, negative, and indecisive attitudes of the patients. In addition, there was no relation between being decisive and indecisive, and the temperament scores except for cyclothymic scores. Indecisive attitude to termination was associated with higher cyclothymic scores (5 (1-13) for decisive patients, 7 (0-17) for indecisive patients, p=0.035). Conclusion: We found that affective temperaments measured by the TEMPS-A are not related to the attitudes about prenatal screening or diagnostic tests or termination. Indecisive attitude to termination was associated with higher cyclothymic scores.Öğe Serum Copeptin Levels in Threatened Preterm Labor(TAYLOR & FRANCIS INC, 2020) Tulmac, Ozlem Banu; Sayan, Cemile Dayangan; Dag, Zeynep Ozcan; Oguz, Yuksel; Gencosmanoglu, Gulenay; Caglar, Turhan; Kisa, UclerAim: We investigated maternal copeptin level's usefulness in prediction of preterm birth. Materials and methods: The study was comprised of 97 pregnant women hospitalized for threatened preterm labor and 35 healthy pregnant women without preterm labor. Serum copeptin were compared with likelihood of threatened preterm labor timing of delivery and time interval to delivery. Result: Copeptin level of threatened preterm labor group was higher than of control group [7.76(0.39-35.62) ng/mL, 6.23(1.64-36.88) ng/mL, respectively, p = .04]. Copeptin levels of women did not differ according to preterm or term birth [7.76(0.69-35.62) ng/mL, 6.73(0.39-36.88) ng/mL, respectively, p = .22). Quartiles of copeptin levels were not associated with risk status or preterm birth. Conclusions: Serum copeptin is higher in threatened preterm labor. It does not differentiate those with threatened preterm labor verses preterm birth.Öğe A very rare cause of recurrent back pain: hematocolpometra(Soc Romana Ultrasonografe Medicina Biologie-Srumb, 2016) Dag, Zeynep Ozcan; Tulmac, Ozlem Banu; Isik, Yuksel…
