Yazar "Turk, M." seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim
    Öğe
    Antenna-type radiofrequency generator in nanoparticle-mediated hyperthermia
    (Royal Soc Chemistry, 2016) Nasseri, B.; Yilmaz, M.; Turk, M.; Kocum, I. C.; Piskin, E.
    Induction of hyperthermia using nanoparticles with specific magnetic, electrical, acoustic, optical or thermal properties is a potential alternative to conventional thermal ablation in cancer therapy. In this study, for the first time we employed an antenna-type radiofrequency (RF) generator as the energy source and as a proof of concept the effects of nanoparticles of varying structures and sizes, such as super-paramagnetic iron oxide nanoparticles (SPIONs), gold-coated superparamagnetic iron oxide nanoparticles (Au@SPIONs), spherical gold nanoparticles (AuNPs), and gold nanorods (AuNRs) on RF hyperthermia were examined to determine hyperthermia efficiency of the antenna-type RF generator. In preliminary experiments, RF was applied at varying powers to various nanoparticle solutions. In all cases, temperature rises due to exposure of RF radiation to nanoparticles were captured by using an infrared thermal camera. This procedure was applied to in vitro tests of fibroblast (L-929) and breast cancer (MCF-7) cell lines. Cell viability, apoptosis and necrosis were evaluated in both cell lines to comprehensively determine cell toxicity. Due to their particle size and chemical nature, SPIONs, in the case of highest RF power and nanoparticle concentration, resulted in the lowest cell viability and highest levels of apoptosis and necrosis.
  • Küçük Resim
    Öğe
    Comparison of the Mechanical Properties of Platelet-Rich Fibrin and Ankaferd Blood Stopper-loaded Platelet-rich Fibrin
    (Wolters Kluwer Medknow Publications, 2018) Aktas, A.; Ozer, T.; Sen, M.; Turk, M.; Karabulut, E.
    Background and Aim: Platelet-rich fibrin (PRF) can be named as a natural fibrin-based biomaterial favorable to increasing vascularization and able to guide epithelial cell migration to its surface. The membrane has a significant positive effect on protecting open wounds and accelerating healing. Similar to PRF Ankaferd Blood Stopper (ABS) also has positive effects on wound healing. The aim of this study was to detect if we can improve known physical properties of PRF combining with ABS. This idea was based on the known mechanism of ABS in forming protein network without damaging any blood cells. Materials and Methods: A total of 25 adult rabbits used for collecting 5-7 ml of blood passively with the help of winged blood collection needle to the test tube. Collected samples were centrifuged at 3000 rpm for 10 min. Two similar samples obtained from each animal and one of the samples was placed in 20% ABS 80% saline solution for 5 min. Mechanical properties of the membrane samples were measured using Universal Testing Machine. Results: There is the statistically significant difference between PRF and ABS added PRF in elongation/mm (dL) and elongation/% at break values. Maximum force (fMax) and modulus values did not show any statistically significant differences. Conclusion: ABS loaded PRF causes better physical properties. This combination seems to exhibit superior performance when used as a membrane barrier solely. Advanced studies can be done on biological properties of ABS loaded PRF, especially on tissue healing.
  • [ X ]
    Öğe
    Effect of Alginate Incorporated Fmoc-FF Hydrogels on Chondrocyte Behaviour
    (Mary Ann Liebert, Inc, 2015) Celik, E.; Bayram, C.; Akcapinar, R.; Turk, M.; Denkbas, E. B.
    …
  • [ X ]
    Öğe
    The interaction of fibroblast and endothelial cells with electrospun nanofibrous Nap-FFGRGD reinforced pcl peripheral nerve regeneration conduits
    (Wiley-Blackwell, 2014) Polat, E.; Meifeng, Z.; Kong, D.; Turk, M.; Piskin, E.
    …
  • Küçük Resim
    Öğe
    Novel Phthalocyanines Containing Guaiacol Azo Dyes: Synhthesis, Antioxidant, Antibacterial, and Anticancer Activity
    (Pleiades Publishing Inc, 2018) Kantar, C.; Kaya, B.; Turk, M.; Sasmaz, S.
    In an attempt to understand the antibacterial, antioxidant, and anticancer properties of phthalocyanines containing azo dye, new metallophthalocyanines (M: Mn, Co, Zn) substituted with guaiacol azo dyes are described. The high DPPH scavenging and ferrous ion chelating activity are obtained from almost all compounds. All compounds exhibit a poor antibacterial activity against the studied bacteria. Cytotoxicity, apoptotic and necrotic effects are examined on human breast cancer cells (MCF-7) and fibroblast cells. It is determined that methoxy groups at newly synthesized compounds increase the antioxidant property but decrease other antibacterial and anticancer properties.
  • Küçük Resim
    Öğe
    Synthesis and characterization of poly(glycerol-co-sebacate-co-epsilon-caprolactone) elastomers
    (Wiley-Blackwell, 2016) Aydin, H. M.; Salimi, K.; Yilmaz, M.; Turk, M.; Rzayev, Z. M. O.; Piskin, E.
    In this study, poly(glycerol-co-sebacate-co-epsilon-caprolactone) (PGSCL) elastomers were synthesized for the first time from the respective monomers. The structural analysis of PGSCL elastomers by nuclear magnetic resonance (H-1-NMR) and Fourier transform infrared spectroscopy (FTIR) revealed that the elastomers have a high number of hydrogen bonds and crosslinks. X-ray diffraction (XRD) and thermal analysis indicated an amorphous state. Differential scanning calorimetry (DSC) analysis showed that the elastomers has a glass transition temperature (T-g) of -36.96 degrees C. The Young's modulus and compression strength values were calculated as 46.08MPa and 3.192MPa, respectively. Calculations based on acid number and end groups analysis revealed a number average molecular weight of 148.15kDa. Even though the foaming studies conducted by using supercritical CO2 resulted in a porous structure; the obtained morphology tended to disappear after 48h, leaving small cracks on the surface. This phenomenon was interpreted as an indication of self-healing due to the high number of hydrogen bonds. The PGSCL elastomers synthesized in this study are flexible, robust to compression forces and have self-healing capacity. Thanks to good biocompatibility and poor cell-adhesion properties, the elastomers may find diverse applications where a postoperative adhesion barrier is required. Copyright (c) 2013 John Wiley & Sons, Ltd.
  • [ X ]
    Öğe
    Synthesis, cytotoxic and biological activities of new partly and fully mono- and dispiro-4-methoxybenzylaminophosphazenes.
    (Amer Soc Cell Biology, 2018) Kuzey, N. Guven; Asmafiliz, N.; Acik, L.; Aydin, B.; Turk, M.; Cerci, N.
    …