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    First detection and molecular characterisation of a pigeon aviadenovirus A and pigeon circovirus co-infection associated with Young Pigeon Disease Syndrome (YPDS) in Turkish pigeons (Columba livia domestica)
    (Wiley, 2022) Sahindokuyucu, Ismail; Turkmen, Merve Biskin; Sumer, Tugce; Elhag, Ahmed Eisa; Alcigir, Mehmet Eray; Yazici, Zafer; Barry, Gerald
    Pigeon aviadenovirus A and Pigeon circovirus are both DNA viruses, infect and cause severe clinical diseases in pigeons. These viruses are associated with an immunosuppression syndrome similar to 'Young Pigeon Disease Syndrome' (YPDS). This study reports the identification of a natural co-infection, with severe clinical signs (crop vomiting, watery diarrhoea, anorexia and sudden death) of Pigeon aviadenovirus A and Pigeon circovirus in a breeding pigeon flock in Central Anatolia, Turkey. Both viruses were isolated from pigeons pooled internal organs using primary chicken embryo kidney cell cultures (CEKC) and specific pathogen-free (SPF) embryonated chicken eggs. Also, both viruses were identified by PCR amplification followed by Sanger sequencing whereas histopathological examination showed degenerated hepatocytes with basophilic intranuclear viral inclusions. As known, both viruses typically have similar transmission characteristics and common clinical manifestations; however, co-infection may exacerbate the disease with devastating outcomes. This is the first report of its kind in Turkey for those viruses and is essential for the protection against these kinds of infections in pigeons.
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    The effects of antivenom administrations on the brain tissue of experimentally envenomed pregnant rats and their pups with Androctonus crassicauda scorpion venom during organogenesis period
    (Pergamon-Elsevier Science Ltd, 2021) Demirel, Murside Ayse; Alcigir, Mehmet Eray; Ozkan, Ozcan; Turkmen, Merve Biskin
    This study aims to show the changing effects of Androctonus crassicauda venom and A. crasicauda specific antivenom during pregnancy in brain tissue of dams and their pups. Totally, 12 pregnant-Wistar Albino rats were randomly divided into two groups as venom-antivenom administration (n = 6) and control groups (n = 6). In venom-antivenom administration group (VAV), the sublethal dose of A. crassicauda venom dissolved in 1 mL physiological saline solution was subcutaneously (s.c.) injected into pregnant rats during organogenesis period (between 7 and 13 days of pregnancy). Four hours after each venom injection, 1 mL/s.c. dose of the specific antivenom was administered to rats of VAV group. The rats in control group were given sterile saline solution 1 mL/s. c. In both groups, the fetuses were surgically delivered on the 21st day of pregnancy; dams and pups were sacrificed on postnatal 21 days, and their brain tissues were removed. The brain tissue of dams and their pups were evaluated histopathologically and immunohistochemically. To show the neuronal damages, 8-hydroxy-2deoxyguanosine (8-OHDG) and amyloid beta precursor protein (ABPP) immunoexpressions were scored in cerebrum, cerebellum, pons and medulla oblongata of brain. To show the neuroprotection, reelin and beta-arrestin immunoexpressions were scored again in the same way. In this context, 8-OHDG immunoexpressions were increased in neocortex, hippocampus and nucleus accumbens when compared with that of control group. Amyloid beta precursor protein was negative in both groups. Reelin and beta-arrestin partly increased in fore and mid brain of VAV group as a reaction against neuronal damages when compared with that of control pups. The authors believe that prompt intervention using anti-venom to scorpion envenomation can partly stop neuronal damages. This neuroprotection may be increased to high and serial doses of anti-venom to save neonatal lives.
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    Unusual localization of squamous cell carcinoma clinically mimicking mammary carcinoma in an Akkaraman sheep
    (2022) Elifoğlu, Taha Burak; Turkmen, Merve Biskin; Macun, Hasan Ceyhun; Kul, Oguz
    Squamous cell carcinoma (SCC) is a malignant epithelial tumor of skin. All species of animals are vulnerable to SCC and, sheep are very rarely developing this type of skin carcinoma. The purpose of this report was to describe unusual mammary lobe localization of SCC showing a great resemblance to the mammary tumor according to its gross and clinical examinations. The patient was brought to obstetrics and gynaecology department and, tumoral tissue was totally extirpated with a suspicion of mammary tumor. The diagnosis made as differentiated squamous cell carcinoma originated from the skin surface and invading through the dermis and subcutis but mammary gland parenchyma was remained intact. There are only few reports of SCC cases belonging to the skin of the mammary area in sheep. Therefore, it is thought that this case will make a scientific contribution with its originality and rarity.