Yazar "Ulusoy, S." seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Do viral infections have a role in benign paroxysmal positional vertigo?(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2015) Hanci, D.; Ulusoy, S.; Muluk, N. B.; Cingi, C.Do viral infections have a role in benign paroxysmal positional vertigo? Objectives: To investigate the role of viral infection in benign paroxysmal positional vertigo (BPPV). Methods: In this retrospective study, 483 patients with BPPV were included in the study group. The control group consisted of 461 healthy subjects. In both groups, serologic analysis of viral agents (HSV1, HSV2, Herpes zoster, EBV, CMV, adenovirus, influenza, and parainfluenza virus) was performed. Results: With the exception of influenza and parainfluenza, all viral serology values were higher in the BBPV group than the control group. We also observed seasonal variation. The BPPV group exhibited elevated values for HSV1 and adenovirus in March and May, for Herpes zoster, adenovirus, and influenza in April, for HSV1 in June, and for HSV1 and CMV in September, compared to the control group. In October, the BPPV group showed increased values for all of the viruses studied, compared to the control group. Conclusion: BPPV is associated with positive viral serology, particularly during certain months of the year, mainly in spring and autumn. Viral infection might promote BPPV attacks due to the development of vestibulopathy or induce secondary BPPV via viral infection-related neurolabyrinthitis.Öğe Effect of botulinum-A toxin to cremaster muscle: an experimental study(Springer-Verlag, 2003) Cakmak, M.; Caglayan, F.; Erdemoglu, A.K.; Ulusoy, S.Objective: A controversy exists on the definition, etiology and treatment of the retractile testes. In the present experimental study, we aimed to show the effect of botulinum-A toxin (Botox) on cremasteric muscle of a rat, and whether it may be an alternative to surgical treatment of retractile testis. Methods: Ten Wistar rats were used in the study. By stimulating cremasteric reflex, five compound muscle action potentials (CMAP) of the right and left cremasteric muscles of each rat were recorded using surface electrodes. Intramuscular injection of botulinum-A toxin was done to the right side. Saline was injected to the left cremasteric muscles, and the left side also served as control. CMAP of the cremasteric muscles were recorded 45 days after the injection. Statistical analysis was done using Wilcoxon Signed rank test. Results: Mean CMAP of the right side was 3.25+/-1.39 muV before the injection and 0.44+/-0.25 muV after botulinum-A toxin injection. The difference was statistically significant (p<0.05). Mean CMAP on the left side was 3.48+/-0.32 muV and 3.14+/-1.12 muV at baseline and the end of the study, respectively. The difference was not statistically significant (p>0.05). Conclusion: The botulinum-A toxin paralyzes the cremasteric muscles of the rats. As cremasteric hypertonicity is accepted as one of the reasons for retractile testes, botulinum-A toxin injection to cremasteric muscles may be helpful in diagnosis and may be an alternative to surgical treatment of this pathology in repeated dosages. Long-term evaluation of this paralysis is necessary.Öğe Efficacy of povidone-iodine in preputial antisepsis(Blackwell Publishing Ltd, 2003) Çakmak, M.; Çaglayan, F.; Kılıç, D.; Kaygusuz, S.; Çakmak, A.; Ulusoy, S.; Osluk, N.Wound infection after a surgical procedure is one of the main problems affecting the success of an operation. The prepuce is used in hypospadias surgery and in tissue defects in reconstructive surgery. The objective of this study is to determine the efficacy of povidone-iodine and surgical soap in preputial skin preparation. Ninety-four healthy children were divided into three groups. After obtaining preputial skin swabs, an application of povidone-iodine 10% was made and skin swabs were obtained after two and five minutes in group 1. An additional application of povidone-iodine after two minutes was made in group 2 and swabs taken. Group 3 received a local scrub with surgical soap and an application of povidone-iodine. Results showed that, despite painting with povidone-iodine and/or local cleaning with surgical soap, it is not possible totally to eradicate the micro-organisms in the prepuce. Surgical soap decreases the colony count, which can lead to increased effectiveness of povidone-iodine after painting. We recommend preoperative local cleaning with surgical soap before surgical painting.Öğe Local allergic rhinitis - a narrative review(Verduci Publisher, 2024) Manole, F.; Muluk, N. Bayar; Oguz, O.; Ulusoy, S.; Scadding, G. K.; Prokopakis, E.; Kalogjera, L.This narrative review aims to provide an up-to-date definition of local allergic rhinitis (LAR), its classification, mechanisms, comorbidities, recommendations for diagnosis and treatment, and define needs in this area. Both 'PubMed' and 'Science Direct' literature was reviewed systematically, and a manual search for studies not previously encountered in the databases was also carried out. Published studies were identified in PubMed covering the period from 1947 to 2022. The following keyword search strategy was used: (local allergic rhinitis* OR entopy* OR local Immunoglobulin E * OR nasal specific Immunoglobulin E). LAR involves Type 2 nasal inflammation with local IgE and cannot be diagnosed by systemic methods, such as skin prick or blood IgE tests. A nasal allergen challenge is necessary for diagnosis. LAR can respond to usual AR treatments, including allergen specific immunotherapy (AIT). LAR is a novel entity that requires additional investigation in terms of prevalence, proper diagnosis, treatment, and prognosis. The target outcomes and possible benefits of this review are to achieve a consensus for the study and diagnosis of LAR and increase interest in this area.Öğe Local allergic rhinitis – a narrative review(Verduci Editore s.r.l, 2024) Manole, F.; Muluk, N.B.; Oğuz, O.; Ulusoy, S.; Scadding, G.K.; Prokopakis, E.; Kalogjera, L.This narrative review aims to provide an up-to-date definition of local allergic rhinitis (LAR), its classification, mechanisms, comorbidities, recommendations for diagnosis and treatment, and define needs in this area. Both ‘PubMed’ and ‘Science Direct’ literature was reviewed systematically, and a manual search for studies not previously encountered in the databases was also carried out. Published studies were identified in PubMed covering the period from 1947 to 2022. The following keyword search strategy was used: (local allergic rhinitis* OR entopy* OR local Immunoglobulin E * OR nasal specific Immunoglobulin E). LAR involves Type 2 nasal inflammation with local IgE and cannot be diagnosed by systemic methods, such as skin prick or blood IgE tests. A nasal allergen challenge is necessary for diagnosis. LAR can respond to usual AR treatments, including allergen specific immunotherapy (AIT). LAR is a novel entity that requires additional investigation in terms of prevalence, proper diagnosis, treatment, and prognosis. The target outcomes and possible benefits of this review are to achieve a consensus for the study and diagnosis of LAR and increase interest in this area. © 2024 Verduci Editore s.r.l. All rights reserved.Öğe Mechanisms and solutions for nasal drug delivery - a narrative review(Verduci Publisher, 2022) Ulusoy, S.; Muluk, N. Bayar; Karpischenko, S.; Passali, G. C.; Negm, H.; Passali, D.; Milkov, M.The aim of this paper is to review mechanisms and solutions for nasal drug delivery. Literature survey was performed via PubMed, Google Scholar, Google, and ProQuest Central database of Kirikkale University. The nasal lining presents a large area of endothelium of variable permeability and with a rich vascular supply. Advantages of this route include eliminating first-pass metabolism and being easily accessible. The nasal route enables some agents which are otherwise difficult to administer to enter the systemic circulation, for example, low molecular mass compounds with high polarity, peptides, or proteins. There are three principal factors that influence the extent to which drugs can be absorbed through the nasal lining, namely the physico-chemical characteristics of the drug molecule itself, the action of the mucociliary system within the nose, and the presence of any factors increasing nasal absorption. A key factor limiting the use of the intranasal route of administration is insufficient absorption through the nasal mucosa. A number of drugs in development cannot be administered intranasally because their bio-availability following nasal administration is too low. There has been considerable research focus on methods to enhance absorption via the nasal mucosa. In this chapter, we review the literature related to this problem and discuss potential solutions.Öğe Potential protective effect of resveratrol on acoustic trauma: electron microscopy study(Verduci Publisher, 2016) Hanci, D.; Ulusoy, S.; Acar, M.; Burukoglu, D.; Kutlu, H. M.; Muluk, N. Bayar; Cingi, C.OBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group 1 (Control, n = 6), Group 2 (AT, n = 6), and Group 3 (resveratrol + AT). The rats in Group 2 were exposed to AT. The rats in Group 3 received resveratrol (300 mg/kg/day) via gavage for 7 days. On day 7, the rats were exposed to AT 10 min following resveratrol treatment. Histological sections of the cochleae were examined using light microscopy, transmission (TEM), and scanning electron microscopy (SEM). RESULTS: The cochlear hair cells, stereocilia, and Deiters' cells of the control group appeared normal in all microscopic evaluations. In Group 2, light microscopy revealed predominantly inner hair cell loss, although the outer hair cells were affected. TEM and SEM examination showed severe loss of stereocilia and SEM revealed stereocilia arranged in an asymmetric array. The cochlear structure in Group 3 appeared well preserved under the light microscope, and although TEM and SEM revealed stereocilia loss, the hair cells and stereocilia appeared near normal compared with those of Group 2. CONCLUSIONS: Resveratrol may have a protective effect against AT damage in the cochlea, most likely through its antioxidant activity. Our results may be useful for studies in humans exposed to AT and noise-induced hearing loss related to chronic exposure to occupational noise.Öğe The results of national newborn hearing screening (NNHS) data of 11,575 newborns from west part of Turkey(Verduci Publisher, 2014) Ulusoy, S.; Ugras, H.; Cingi, C.; Yilmaz, H. B.; Muluk, N. B.OBJECTIVE: In this study, we aimed to review the National Newborn Hearing Screening (NNHS) programme data obtained from Corlu, located in west part of Turkey for the last 4 years. SUBJECTS AND METHODS: A total 11575 newborns that were either born in Corlu State Hospital or referred from other Health Care Centers, between September 2009 and November 2012 were included into the study. Automated-Transient Evoked Otoacoustic Emission (A-TEOAE) test and Automated-Auditory Brainstem Response (A-ABR) were used as screening tests. When the newborn had failed at the initial A-TEOAE test, then the test was repeated after 15 days. If the same result was obtained at the second test; the newborns were referred for ENT examination. A-TEOAE and A-ABR screening tests were performed as the third stage evaluation. The failed newborns were referred for clinical ABR test. RESULTS: Out of 11575 newborns, 593 (5.12%) had failed the test and they were referred for clinical ABR. Out of these 593 neonates, 470 had passed the diagnostic ABR test at the referral center. Bilateral and unilateral sensori-neural hearing loss (SNHL) was detected at 15 and 7 babies respectively, 10 of 22 of these babies had risk factors such as family history of hearing loss, and parental consanguinity. CONCLUSIONS: The final hearing impairment and risk factor rates of our study was similar with literature. Although referral rates and the number of default babies gradually decreased in the last 4 years; definitive diagnosis and hearing aid initiation times need to improvement.Öğe The intranasal trigeminal system: roles in rhinitis (allergic and non-allergic)(Verduci Publisher, 2022) Ulusoy, S.; Muluk, N. Bayar; Scadding, G. K.; Passali, G. S.; Dilber, M.; Gevaert, P.; Passali, D.The aim of this paper is to review intranasal trigeminal system and associated reflexes. The literature survey was performed on PubMed, ProQuest Central database of Kirikkale University and Google Scholar. The intranasal trigeminal system and associated reflexes play an important role in humans in both health and disease, including in rhinitis of non-allergic and mixed type. The intranasal trigeminal nerve provides sensory perception to the lining of the nose, supplying information on how patent the nasal airway is and responding to various chemical signals. The reflexes known to exist within the intranasal trigeminal system are nasobronchial reflex, trigemino-cardiac reflex, nasogastric reflex, and nasal cycle. The intranasal trigeminal system and its reflexes play a vital role in normal human physiology. Alterations in how this system operates may underlie multiple forms of rhinitis and more research is needed to fully understand the mechanisms involved.
