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    Coxiella burnetii seropositivity and coronary ectasia
    (Cardiology Academic Press, 2014) Dogru M.T.; Alpay Y.; Simsek V.; Unal N.; Askar S.; Ebinc H.; Yildirim N.
    Bacterial infections could contribute to atherosclerotic inflammation. We investigated the association of Coxiella Burnetii seropositivity with the atherosclerotic lesion types (obstructive and/or ectatic), serum lipid profile, nitric oxide (NO),total sulfhydryl (SH) groups and malonyldialdehyde (MDA) levels. A total of 150 participants (73 male, mean age: 56.6 ± 11.4 years; 77 female, mean age: 57.3 ± 13.0 years) were enrolled into the study. Coronary angiography was performed all the participants. We also performed serum lipid profile, NO, SH groups and MDA levels to determine the changes in chronic and acute Coxiella burnetii infections. The patients with obstructive and ectatic coronary artery lesions were of higher Coxiella phase I IgG titer (The marker of chronic Coxiella infection) than those of other coronary artery disease groups(One Way ANOVA, p=0.001). There were higher serum total cholesterol levels in the patients with chronic Coxiella infection than those of other patients. The chronic Coxiella Burnetii infection may be an important factor for the formation of coronary artery ectasia on basement of atherosclerotic coronary artery disease. Hyperlipidemia might also facilitate and augment this association.
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    The relationship of Coxiella burnetii seropositmty between farm animals and their owners: A pilot study
    (2010) Dogru A.K.; Yildirim M.; Unal N.; Gazyagci S.
    Q fever is a zoonotic disease caused by Coxiella burnetii. This study aimed to detect the relationship of C. burnetii seropositivity between farm animal owners and their animals. Blood serums of 20 farm animal owners, 32 cow and 88 sheep were investigated with indirect Immuno Fluorescent Assay (IFA) using C. burnetii phase I and II antigens. Milk samples of the same animals were tested for C. burnetii by PCR. The serological test results of animals and their owners were compared by statistically methods to reveal the interdependence and correlations. The seropositivities of IgG antibodies against C. burnetii were 90.0% for farm animal owners, 53.1% for cows and 63.6% for sheep. All of the animal owners were consuming dairy products made from their own animals raw milk. However, as shown by PCR results, none of the tested cows and sheep were responsible for shedding of C. burnetii through their milks. Although, there was no correlation between the shedding pattern and serological results of animals, there was a significant correlation between the serological results of animals and their owners for both phase I and II antigens against C. burnetii. There are statistically important relationships between farm animals and their owners about phase I and phase II IgG titration levels against C. burnetii. Moreover, there was close dependency between the presence of chronic C. burnetii infections in animals and their owners. On the other hand, serological results of milk samples are not in significant correlation with the serologically dependency of animals and their owners. © Medwell Journals, 2010.