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    Late dissemination of ependymoma: case report
    (Soc Espanola Neurocirugia, 2007) Bademci, G.; Tun, K.; Erden, E.; Evliyaoglu, C.; Unlu, A.
    Spinal cord dissemination over 10 years after surgical removal of the fourth ventricle ependymoma without local recurrence is extremely rare. A 49-year-old male underwent a macroscopically gross total removal of the fourth ventricle ependymoma and postoperative radiothe rapy to the posterior fossa. Twelve years after the initial operation, the patient complained from uncontrolled fever attacks, low back pain and numbness of the legs. Spinal Magnetic Resonance Imaging revealed intradural extramedullary mass lesions located at the thoracic 2-3 and lumbar 5 vertebrae levels. Cerebrospinal fluid exami nation showed no tumour cells. He underwent total excision of these spinal lesions. Although the majority of the recurrences take place within a few years after surgery, we experienced a case with multiple spinal disseminations 12 years after the resection of the fourth ventricle ependymoma and administration of the radiation therapy to the posterior fossa. Up to our knowledge, this case represents the second unusual late recurrence reported in the literature. We conclude that low grade ependymomas should be followed neurologically and radiologically for more than 10 years after the initial treatment.
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    Öğe
    The efficacy of platelet-rich plasma gel in MRSA-related surgical wound infection treatment: an experimental study in an animal model
    (Springer Heidelberg, 2018) Cetinkaya, R. A.; Yilmaz, S.; Unlu, A.; Petrone, P.; Marini, C.; Karabulut, E.; Urkan, M.
    IntroductionThe wound healing properties of platelet-rich plasma (PRP) gel have been documented in many studies. PRP gel has also become a promising agent for treating surgical site infections. In this study, we investigated the antibacterial activity and wound healing effectiveness of PRP in an animal model of Methicillin-resistant Staphylococcus aureus subsp. aureus (MRSA N315)-contaminated superficial soft tissue wounds.Materials and methodsSubcutaneous wounds in Wistar Albino male rats were created by making two cm midline incisions followed by inoculation of microorganisms. Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA+PRP, MRSA+Vancomycin, and MRSA+Vancomycin+PRP groups. We inoculated 0.1mL (3x10(8) CFU/mL) of MRSA in contaminated groups. After 8 days, all rats were killed, wounds were excised and subjected to histopathologic examination, and MRSA counts were determined.ResultsMRSA counts in MRSA, MRSA+PRP, MRSA+Vancomycin and MRSA+Vancomycin+PRP groups were 5.1x10(6) (SD0.4) CFU/mL, 4.3x10(6) (SD +/- 0.7) CFU/mL, 2.3x10(6) (SD +/- 0.3) CFU/mL, 1.1x10(6) (SD +/- 0.4) CFU/mL, respectively. The inflammation scores of MRSA+PRP, MRSA+Vancomycin, and MRSA+Vancomycin+PRP groups were significantly lower than the MRSA group. MRSA+Vancomycin+PRP group inflammation score was significantly lower than the MRSA+PRP group.DiscussionAll treatment groups were effective in wound healing and decreasing the MRSA counts. MRSA+PRP combined created identical inflammation scores to the PRP group. More in vivo studies are required to corroborate these findings.