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    Central corneal thickness in patients with mild to moderate rosacea
    (Canadian Ophthal Soc, 2012) Onaran, Zater; Karabulut, Ayse Anil; Usta, Gulsah; Ornek, Kemal
    Objective: We aimed to evaluate central corneal thickness (CCT) in patients with rosacea in comparison to a healthy control group and to investigate any correlations by using the Schirmer test, tear break-up time (TBUT), and disease severity. Design: Prospective nonrandomized study. Participants: Patients with mild to moderate rosacea (n = 51) and a group of healthy individuals (n = 51) were included. Method: Patients were evaluated by a dermatologist; disease severity was determined and total rosacea severity score was calculated for each patient. CCT measurements were performed using ultrasonic pachymetry. Tear function tests, including Schirmer and TBUT, were also performed. Results: The mean CCT value was significantly lower in patients with rosacea than in the control group (544.91 +/- 29.41 mu m vs 559.40 +/- 24.18 mu m, p = 0.003). The mean Schirmer test value was significantly lower in patients than in controls (10.54 +/- 6.09 mm vs 19.13 +/- 4.24 mm, p < 0.0001), and the mean TBUT was shorter in the group with rosacea than in the controls (8.32 +/- 3.50 s vs 16.67 +/- 5.76 s, p < 0.0001). CCT values were found to be correlated with the Schirmer test values in the rosacea group (r = 0.33, p = 0.01). Conclusions: Patients with rosacea have thinner corneas, which could be attributed to the observed deteriorated tear function parameters. Candidates for corneal photoablation surgery should be evaluated regarding rosacea disease because the postoperative period could be complicated by decreased ocular wetting and corneal thinning, even in overlooked mild forms.
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    Corneal and conjunctival sensitivity in rosacea patients
    (Elsevier Science Bv, 2016) Ornek, Nurgul; Karabulut, Ayse Anil; Ornek, Kemal; Onaran, Zafer; Usta, Gulsah
    Purpose: To assess corneal and conjunctival sensitivity in rosacea patients. Methods: A total of 55 patients with rosacea and 37 control subjects participated in the study. Corneal and conjunctival sensitivity was determined by Cochet-Bonnet esthesiometer. Subjective symptoms of ocular dryness were evaluated using Ocular Surface Disease Index (OSDI). Schirmer's I test (ST), tear breakup time (tBUT) and ocular surface staining with fluorescein were carried out to measure objective signs. Results: The mean corneal and conjunctival sensitivity did not differ significantly between rosacea patients and controls (all p > 0.05). Schirmer's I test and tBUT were significantly reduced (p = 0.004 for OD and p < 0.001 for OS) and grade of ocular surface staining was significantly high (p = 0.018 for OD and p = 0.038 for OS) in rosacea patients. Corneal and conjunctival sensitivity did not show significant correlation with ST, tBUT, ocular surface staining (Oxford Schema), duration of rosacea and OSDI score. Conclusions: Corneal and conjunctival sensitivity did not change significantly in rosacea.