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  • Küçük Resim
    Öğe
    Başağrısının Nadir Bir Nedeni: Süperior Konka Aşırı Pnömatizasyonu
    (2015) Şimşek, Gökçe; Saka, Cem; Vuralkan, Erkan; Serin, Ömer; Akın, İstemihan
    Pnömatize süperior konka nadir bir başağrısı sebebidir. Nazal endoskopi, tanı için yetersiz kalabilir ve tanının doğrulanması için koronal bilgisayarlı tomografi gerekir. Medikal tedaviye rağmen 6 aydır baş ağrısı yakınması olan 52 yaşında bayan hasta kliniğimize başvurdu. Muayene ve görüntüleme yöntemleri sonucunda süperior konkada aşırı pnömatizasyon saptanan hastaya endoskopik sinüs cerrahisi uygulandı. Postoperatif dönemde hastanın şikayetlerinin gerilediği izlendi
  • Küçük Resim
    Öğe
    Does melatonin alleviate ototoxic effect caused by administration of cisplatin?
    (2019) Tokgöz, Sibel Alıcura; Şimşek, Gökce; Vuralkan, Erkan; Çalışkan, Murat; Besaltı, Ömer; Akın, Istemihan
    Aim: In this study, it was aimed to experimentally investigate the protective effects of melatonin in the cisplatin-induced ototoxicity. Material and Methods: Ten Wistar-albino rats were included in the study. Two equal groups were generated randomly as cisplatin and melatonin groups. Rats’ underwent Auditory Brainstem Response (ABR) and Distortion Product Otoacoustic Emission (DPOAE) testing before the drug administration and the results were recorded. Both tests were repeated 72 hours after the cisplatin administration in all rats. Results: Significant difference was found between the I-IV interval values before the treatment and after the treatment both in cisplatin and melatonin group. As well as the significant difference in hearing threshold value changes, statistically, significant differences in ABR-I and ABR-IV interval variations were also seen between the cisplatin and melatonin groups. A statistically significant decrease was found between the initial and final control SNR (signal-to-noise ratio) levels within the cisplatin group in the evaluations at 2000Hz, 3000Hz and 4000Hz. Statistically, significant differences were observed between SNR levels when the melatonin group was compared with the cisplatin group. Conclusion: Melatonin appears to reduce cisplatin-induced ototoxicity in rats. Although, the use of supplementary therapies targeting to reduce the toxic effects in clinical studies is still a controversial point.
  • Küçük Resim
    Öğe
    Effects of methotrexate in a toluene diisocyanate-induced allergic rhinitis rat model
    (2018) Tokgöz, Sibel Alicura; Şimşek, Gökçe; Vuralkan, Erkan; Bayır, Ömer; Köybaşıoğlu, F. Fulya; Çalışkan, Murat; Beşaltı, Ömer
    Objectives: This study aims to investigate the therapeutic effect of low-dose topical administration of methotrexate (MTX) in a toluene diisocyanate (TDI)-induced allergic rhinitis rat model. Materials and Methods: The experiments were performed on 18 healthy male Wistar albino rats weighing between 250-270 g. Rats were divided into four study groups: control group (n=5), sham group (n=3), steroid group (n=5), and MTX group (n=5). After the drugs were administered, multiple biopsies were taken bilaterally from the nasal mucosal areas and evaluated histologically for fibrosis, loss of cilia and goblet cells, edema, squamous cell metaplasia, and vascular proliferation. Results: Fibrosis, loss of cilia cells, edema, and vascular proliferation were significantly lower in both MTX and steroid groups than in the control group (p<0.05). There were no statistically significant differences with respect to histopathological parameters between the steroid group and the MTX group (p>0.05). There were no statistically significant differences with respect to loss of goblet cells and squamous cell metaplasia among the studied groups (p>0.05). Conclusion: Methotrexate may be an alternative or adjuvant therapeutic agent in allergic rhinitis.