Yazar "Yücel, Engin" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    Cerebral MRI findings in neonatal hypoglycemia
    (2005) Bademci, Gülşah; Yücel, Engin; Aliefendioglu, Didem
    Metabolic disturbances such as anoxia and hypoglycemia may adversely alter the development of the neonatal brain. While rapid and appropriate diagnosis with adequate therapy has a good prognosis; delayed detection and/or inappropriate therapy increases the risk of the development of irreversible brain damage. Magnetic resonance imaging (MRI) studies are essential in neonatal hypoglycemia to define the characteristics and severity of cerebral lesions after hypoglycemia, to decide the efficacy of preferred treatment modality and to predict the neurologic outcome. Although acute and long-term radiologic abnormalities associated with hypoglycemic episodes in children and adults are well documented, the details of the situation for neonatal hypoglycemia are still emerging. In this review, the impact of MRI findings of neonatal hypoglycemia on diagnosis, monitoring of treatment and neurologic outcome was discussed. © 2005 - IOS Press and the authors. All rights reserved.
  • [ X ]
    Öğe
    Farelerde pentilentetrazol ile geliştirilen epilepsiye endokannabinoidlerin etkisi
    (Kırıkkale Üniversitesi, 2005) Yücel, Engin; Keskil, Semih
    ABSTRACT Yücel Engin, Effects of Endocannabinoids on Pentilenetetrazole induced seizures in mice, University of Kırıkkale, Faculty of Medicine, Department of Neurosurgery, Thesis, Kırıkkale 2005. Pentylenetetrazole (PTZ) is an agent widely used in the assessment of putative anticonvulsant drugs and is suggested to induce repetitive firing of nerve fibers and shorten the refractory period. This agent has been shown to impair GABAA-receptor-mediated inhibitory post-synaptic potentials and conductance. Anandamid is synthesized in neurons, excreted by depolarization and inactivated very quickly. Neonatal rat brain produces significantly more anandamid and its precursors after injury than controls. It has been shown that anandamid protected cerebral neurons of rats in in vitro ischemia. In neuronal disorders such as epilepsy, high levels of endocannabinoid anandamid were observed. Hydrolysis of endocannabinoid anandamid is mediated by CB1 receptors, located in the CNS. Ethanol is a psychoactive and addictive substance with diverse effects in the central nervous system (CNS). After acute application ethanol has an anticonvulsive effect as repeated administrations of high doses with longer withdrawal periods leads to proconvulsant actions, possibly mediated by neuroadaptive changes in NMDA and/or GABAa receptor related mechanisms. In this study we planned to study the anticonvulsant effects of endocannabinoids on PTZ induced seizures. In order to show that Swiss Albino mice were used. The mice were divided into four groups as control, anandamide, WIN- 55.212-2 and ethanol groups. Our findings show that, after i.p. administration of anandamide and ethanol followed by PTZ, latency period was significantly higher than the control, but there was no significant difference between seizure durations. Although latency period of the anandamide group was higher than ethanol group there was no statistical significance. Mortality rates of the ethanol (0%), anandamide (0%) and WIN 55.212- 2 (20%)groups were significantly lower than the control (46%) (p<0,05).ÖZET Yücel E, Farelerde Pentilentetrazol ile oluşturulan epilepsiye Endokannabinoidlerin etkisi, Kırıkkale Üniversitesi Tıp Fakültesi Nöroşirurji Anabilim Dalı Uzmanlık Tezi, Kırıkkale, 2005. Epilepsi, ani bilinç kaybı atakları ile seyreden, konvülziyonlann ve diğer motor aktivitelerin tekrarlayıcı bir paternde görüldüğü kronik nöbetlerle karakterize bir nörolojik bozukluktur. Epilepsinin fizyopatoloj isine dair veya yeni tedavi yaklaşımlarına yönelik çalışmalarda farklı deneysel yöntemler kullanılmıştır. PTZ, antikonvülzan olduğu varsayılan ilaçların değerlendirilmesinde kullanılan, sinir fibrillerinin tekrarlayan şekilde uyarılmasını sağlayan ve refraktör periyodu kısalttığı kabul edilen bir ajandır. Anandamid nöronlarda sentezlenip depolarizasyon ile salınırlar ve hızla inaktive edilirler. Neonatal rat beyninin travma sonrası kontrollere göre belirgin bir şekilde daha fazla anandamid ve onun fosfolipid prekürsörlerini ürettiği gösterilmiştir. İn vitro iskemide anandamidin serebral rat kortical nöronlarını koruduğu gösterilmiştir. Epilepsi gibi nöronal bozukluklarda endokannabinoid anandamidin artmış seviyelerine rastlanmıştır. Endokannabinoid anandamid hidrolizi, endokannabinoid anandamidin ürünü olan [(3)]-etanolaminin formasyonu ile ölçülmüştür. Anandamidin etkileri SSS'de bulunan CB1 reseptör aracılığı ile olur. Etanol SSS'ne yan etkileri olan psikoaktif ve bağımlılık yapan bir ilaçtır. Akut uygulama sonrası etanol antikonvülzif etkilidir ancak yüksek dozlar uzun süreli kesilme periyodlan ile birlikte prokonvülzif etkilidir ve NMDA ve/veya GABAa reseptörleri aracılığı ile etki eder. Bu çalışmada amacımız endokannabinoidlerin PTZ ile oluşturulan epileptik nöbetlerin gelişimini, atakların sayısı ve şiddeti üzerine etkilerini incelemekti. Çalışmada Swiss albino erkek fareler kullanıldı ve kontrol, anandamid WIN 55.212-2, etanol grupları oluşturuldu.
  • Küçük Resim
    Öğe
    Pott's puffy tumor of the vertex years after trauma in a diabetic patient: case report
    (Sociedad Luso-Espanola Neurocirugia, 2005) Evliyaoğlu, Çetin; Bademci, Gülşah; Yücel, Engin; Keskil, Semih
    Pott's puffy tumor is a rare clinical entity characterized by subperiosteal abscess associated with osteomyelitis. It is usually seen as a complication of frontal sinusitis or trauma. This is the unique report of a Pott's puffy tumor located over the vertex of a type 1 diabetic patient with an unusual latency of 14 years following injury. A 27-year old man presented with pain and a soft swelling on his vertex. Magnetic resonance imaging demonstrated subperiosteal abscess in the vertex region associated with dural thickening and perisinusal irregularities of epidural space. Further history revealed that he had a trauma to the same location when he was 13 years old. Considering possible complications due to proximity of the lesion to the sagittal sinus, we retrained from aggressive surgical interventions. We treated our patient with a simple surgical abscess drainage followed by prolonged use of antibiotics and achieved complete therapy. The cellular and humoral elements of the immune system may be disrupted in diabetic patients resulting in such atypical courses and complications of infections. We want to emphasize both importance of the prompt diagnosis of Pott's puffy tumor as intracranial invasion may cause severe neurologic problems, and importance of a surgical intervention tailored for the individual lesion.