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    Atypical hemolytic uremic syndrome in infancy
    (Springer, 2016) Cakar, N.; Ozcakar, Z. B.; Koyun, M.; Acar, B. Celikel; Gulhan, B.; Yurt, A.; Yalcinkaya, F.
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    Familial Mediterranean fever-associated diseases in children
    (Oxford Univ Press, 2017) Ozcakar, Z. B.; Cakar, N.; Uncu, N.; Celikel, B. A.; Yalcinkaya, F.
    Background: MEditerranean FeVer (MEFV) gene encodes for the pyrin protein and a mutated pyrin is associated with a prolonged or augmented inflammation. Hence, various diseases were reported to be associated with familial Mediterranean fever (FMF) or carriers of MEFV mutations. However, systematic evaluation of all associated diseases in children with FMF has not been done previously. Aim: The aim of this study was to investigate the frequency and type of FMF-associated diseases in children. Design and Methods: Files of FMF patients who had been seen in two reference hospitals in Ankara, in the last two years, were retrospectively evaluated. Patients with FMF and concomitant diseases were included to the study. Results: Among 600 FMF patients, 77 were found to have a concomitant disease (12.8%). Thirty patients (5%) had vasculitis; 21 (3.5%) had juvenile idiopathic artritis (JIA); 7 (1.16%) had inflammatory bowel disease (IBD) and 19 had other diseases including 5 patients with isolated sacroiliitis. Overall, 13 (2.17%) patients had sacroiliitis in our cohort. The most frequent mutation was M694V/M694V (44%) and 81% of the patients had at least one M694V mutation. Majority of the patients (74%) developed associated diseases while they were not receiving colchicine therapy. Conclusions: Certain inflammatory diseases including vasculitis, chronic arthritis and IBD were more frequently detected in patients with FMF during childhood. M694V mutation is a susceptibility factor for associated diseases. In countries where FMF is prevalent, clinicians dealing with FMF and other inflammatory diseases should be aware of these associations.
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    Spatial light modulator design and generation of structured electromagnetic waves using digital light processors
    (Wroclaw Univ Science Technology, 2022) Yalcinkaya, F.; Koc, T.; Pala, Z.
    Spatial light modulators (SLMs) are versatile devices used for optical studies. These instruments have a wide area of application in photonics. Additionally, SLMs have potential utility in different applications, such as biomedical applications, laser based surgery for precise cutting and as optical tweezers to separate cells in a petri container. However, the high cost of SLM devices prevents their widespread use in many areas, including industrial areas and scientific research laboratories. This paper demonstrates how to design a digital light processor (DLP) based low-cost SLM and describes how to obtain structured electromagnetic waves with the designed SLM. Therefore, this research was undertaken to design and produce a low-cost SLM device for optical applications. For this purpose, two prerequisites had to be fulfilled, the first was to use suitable components of a projection device with DLP-based digital micro-mirror device (DMD), and the second was to eliminate unnecessary SLM components from the system. Finally, holographic images reflected on the SLM screen were created by using Mathematica software program to change the amplitude and phase of the electromagnetic waves in order to obtain the structured electromagnetic waves.