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    Cerebellum progesterone concentration decreased in canine distemper virus infection
    (Elsevier Sci Ltd, 2007) Yarim, Gül Fatma; Karahan, Siyami; Yarim, Murat
    Progesterone has neuroprotective effects including augmentation of myelination in the central and peripheral nervous system. This study was designed to determine if demyelinating lesions in the cerebellum resulting from canine distemper virus (CDV) infection are associated with progesterone levels. Progesterone was measured using radioinummoassay in samples of the cerebellum, corpus callosum, medulla oblongata, parietal, frontal, temporal, and occipital cortices as well as cerebrospinal fluid (CSF) and plasma collected from ten CDV infected and six non-infected dogs. The cerebellum progesterone level was significantly different between CDV infected (0.66 +/- 0.09 ng/g) and control dogs (1.14 +/- 0.09 ng/g) (p < 0.001); however, no difference was observed for the other CNS regions, plasma and CSF (p > 0.05). The cerebellum progesterone level was also significantly different between acute (0.71 +/- 0.05 ng/g) and chronic cases (0.61 +/- 0.09 ng/g) (p < 0.05). The CDV infected cerebella were also categorized histopathologically according to the severity of demyelinating lesions as mild (n = 5), moderate (n = 2), or severe (n = 3) among which the cerebellum progesterone level was significantly different (p < 0.05). Progesterone concentration was 0.71 +/- 0.05 ng/g in mild, 0.65 +/- 0.10 ng/g in moderate, and 0.56 +/- 0.07 ng/g in severe cases. In conclusion, progesterone concentration decreases in the cerebellum in CDV infection and the severity of demyelinating lesions is the greatest in cerebella with the lowest progesterone concentrations. The results suggest that local impairment of progesterone metabolism may be associated with the initiation and progression of cerebellar lesions in CDV infection. (c) 2006 Elsevier Ltd. All rights reserved.
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    The milk IGF-2 level is positively correlated with milk yield in Anatolian water buffaloes
    (Int Buffalo Information Ctr, 2023) Güler, Hakan; Yarim, Gül Fatma; Yarim, Murat; Duru, Özkan; Gökçeoğlu, Ayris
    The aim of this study was to investigate the relationship between milk insulin-like growth factor-2 (IGF-2) concentration and milk yield in Anatolian water buffaloes. This study was conducted on milk samples from 80 Anatolian water buffaloes. Milk samples collected from buffaloes were evaluated for subclinical mastitis. For this purpose, the California mastitis test and somatic cell count were performed in milk samples taken from four different mammary lobes of buffaloes. The milk IGF-2 level was determined by an enzyme-linked immunosorbent assay kit. Milk IGF-2 concentration ranged from 21.6 ng/ml -63.2 ng/ml in Anatolian water buffaloes. The IGF-2 concentration in Anatolian water buffaloes milk was 40.1 & PLUSMN;8.5 ng/ml. Milk IGF-2 was positively correlated with milk yield (r2=0.941, P<0.01). Our results showed that milk IGF-2 concentration was associated with milk yield in Anatolian buffaloes. These findings show that locally synthesized IGF-2 can affect milk yield. This study contributes to the understanding of the composition of buffalo milk, which has an important value in human nutrition. It is recommended to confirm the results of similar measurements in milk from other animal species used for human consumption.