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    Effects of fullerene C60 on liver tissue in liver ischemia reperfusion injury in rats undergoing sevoflurane anesthesia
    (Taylor & Francis Ltd, 2023) Yavuz, Aydin; Tuna, Ayca Tas; Ozdemir, Cagri; Mortas, Tulay; Kucuk, Aysegul; Kasapbasi, Esat; Arslan, Mustafa
    This study aimed to investigate the effects of fullerene C60 on rat liver tissue in a liver ischemia reperfusion injury (IRI) model under sevoflurane anesthesia to evaluate the ability of nanoparticles to prevent hepatic complications. A total of 36 adult female Wistar Albino rats were divided into six groups, each containing six groups as follows: sham group (Group S), fullerene C60 group (Group FC60), ischemia-reperfusion group (Group IR), ischemia-reperfusion-sevoflurane group (Group IR-Sevo), ischemia-reperfusion-fullerene C60 group (Group IR-FC60), and ischemia-reperfusion-fullerene C60-sevoflurane group (Group IR-FC60-Sevo). Fullerene C60 100 mg/kg was administered to IR-FC60 and IR-FC60-Sevo groups. In the IR group, 2 h of ischemia and 2 h of reperfusion were performed. At the end of reperfusion, liver tissues were removed for biochemical assays and histopathological examinations. Hepatocyte degeneration, sinusoidal dilatation, prenecrotic cells, and mononuclear cell infiltration in the parenchyma were significantly higher in Group IR than in all other groups. Thiobarbituric acid reactive substances levels were significantly higher in Group IR than in the other groups, and the lowest thiobarbituric acid reactive substances level was in Group IR-FC60 than in the other groups, except for Groups S and FC60. Catalase and Glutathione-S-transferase activities were reduced in the IR group compared to all other groups. Fullerene C60 had protective effects against liver IR injury in rats under sevoflurane anesthesia. The use of fullerene C60 could reduce the adverse effects of IRI and the associated costs of liver transplantation surgery.
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    Öğe
    The role of pomegranate seed oil on kidney and lung tissues in the treatment of sepsis: animal pre-clinical research
    (J Infection Developing Countries, 2023) Arslan, Mustafa; Kucuk, Aysegul; Bozok, Ummu Gulsen; Ergoruen, Aydan Iremnur; Sezen, Saban Cem; Yavuz, Aydin; Kavutcu, Mustafa
    Objectives: Sepsis is a common disease with a high mortality. Decreasing the speed is possible with early and intensive therapy. However, most medicines have been tested, but none has proven effective. Therefore, the study aimed to discover the protective and therapeutic effects of pomegranate seed oil (PSO). Methods: The cecal ligation puncture (CLP) method was used to induce sepsis. The experimental procedure was started with the animals divided haphazardly into four groups: control (C), sepsis (CLP), CLP + low dose PSO (CLP + LD), and CLP + high dose PSO (CLP + HD). First, the cecum was filled with feces. The full cecum was tied under the ileocecal valve for ligation and punctured. At 1 hour after CLP, 0.32 mg/kg and 0.64 mg/kg of PSO were administered. 24 hours after, lung and kidney specimens were collected. Results: Neutrophil infiltration/aggregation and alveolar wall thickness decreased in lung with PSO groups compared with the CLP. The findings for overall lung injury were similar. In renal, all parameters were increased in the CLP compared with C, except for vascular vacuolization and hypertrophy. According to the CLP, all parameters were significantly lower in CLP + HD. Furthermore, glomerular vacuolization, degeneration, and necrosis of tubular cell, dilatation of bowman space, and tubular hyaline cylinders reduced CLP + LD versus CLP. Thiobarbituric acid-reactive substances decreased in lung, with the PSO groups. In addition, superoxide dismutase increased in PSO groups versus CLP. Conclusions: We conclude that the high-dose PSO is especially effective in treating sepsis.