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    ASSESSMENT OF THE POSSIBLE RELATIONSHIP BETWEEN DENTAL/ PERIODONTAL CONDITIONS AND SELF-REPORTED REFLUX SYMPTOM INDEX SCORES. A PRELIMINARY STUDY
    (Kırıkkale Üniversitesi, 2017) Keçeli, Hüseyin Gencay; Hatipoğlu, Hasan; Yaylak, Faik; Aydemir Turkal, Hümerya
    Objective: Gastroesophageal reflux disease and laryngopharyngeal reflux are common public health problems, which are known to effect oral cavity. Subjective assessment of symptom severity in patients with gastroesophageal reflux and laryngopharyngeal reflux can be made with self-reported “Reflux Symptom Index”. In this study, possible relation of dental and periodontal conditions with Reflux Symptom Index scores was evaluated.Material and Methods: This study was performed with 135 dental outpatients (52 female and 83 male; aged between 18-63 years). Demographic and clinical variables were procured and Reflux Symptom Index (a nine item and 45-point scale questionnaire) scores were evaluated. Dental and periodontal conditions were assessed with DMFT (decayed, missing, filled teeth) index and Community Periodontal Index scores. Patients were divided into two subgroups according to their RSI values (Reflux Symptom Index ?13; normal and Reflux Symptom Index and gt;13; abnormal) and differences were statistically investigated.Results: Reflux Symptom Index subgroups showed significant difference in all intraoral parameters except decayed teeth number (p and lt;0.05). In addition, Reflux Symptom Index scores did not show constant correlations with DMFT and Community Periodontal Index scores (p and gt;0.05).  Conclusion: Self-reported Reflux Symptom Index merits further investigation before declaring dental and periodontal conclusions in patients with gastroesophageal reflux disease and laryngopharyngeal reflux.
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    Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury
    (Taylor & Francis Ltd, 2012) Arslan, Mustafa; Comu, Faruk Metin; Kucuk, Aysegul; Ozturk, Levent; Yaylak, Faik
    Background: Hepatic ischemia-reperfusion injury is a common clinical problem in hepatic surgery and transplantation. Several cellular and tissue structural and functional alterations are observed in such injury. The aim of this study was to evaluate the effect of dexmedetomidine on lipid peroxidation and erythrocyte deformability during ischemia-reperfusion injury in rats. Methods: Twenty-four Wistar Albino rats were randomly separated into three groups as control (C), ischemia-reperfusion injury (I/R) and dexmedetomidine group (I/R-D). Ischemia was induced with portal clampage for 45 min and reperfusion period was 45 min after declampage. Group I/R-D received dexmedetomidine 100 mu g/kg i.p. 30 min before portal clampage. Serum malondialdehyde and superoxide dismutase activities to document lipid peroxidation and erythrocyte deformability index were investigated. Results: Serum superoxide dismutase and malondialdehyde activity levels were significantly higher and erythrocyte deformability index was decreased in hepatic ischemia-reperfusion group. However, these changes were observed to be prevented with dexmedetomidine treatment when given before portal clampage. Conclusion: These findings clearly indicate that erythrocyte deformability index is decreased in hepatic ischemia reperfusion injury and has a potential role to prevent these alterations. The protective effect of dexmedetomidine on hepatic I/R injury is also decreased lipid peroxidation. Further experimental and clinical investigations may clarify the molecular mechanisms and clinical significance of these findings.