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    Investigation of the effectiveness of algan hemostatic agent in bleeding control using an experimental partial splenectomy model in rats
    (Marmara Univ, Fac Medicine, 2019) Midi, Ahmet; Ekici, Husamettin; Kumandas, Ali; Durmus, Omercan; Bodic, Buse; Tiryaki, Mehmet; Yesilada, Erdem
    Objective: Algan hemostatic agent (AHA) is a plant-based hemostatic agent produced in Turkey. Although, there is a great improvement in the hemostatic technologies, more effective hemostatic products are required to be produced. The aim of this study was to demonstrate the efficacy of AHA in a partial splenectomy model in rats. In addition, in this model, postoperative abdominal adhesion was evaluated. Materials and Methods: In this study 5-7 weeks old 64 rats were used. Rats were randomly divided into 8 groups, each consisting of eight rats (4 groups heparinized and 4 groups non-heparinized). Experimental splenectomy was performed and the gauze impregnated with saline was applied to the control group for the hemorrhage control, the gauze impregnated with liquid AHA, gel and powder form of AHA, was applied to the experimental groups. Results: The time to reach complete homeostasis was significantly shorter in all AHA groups compared to the control group. The powder and the gel forms of AHA stopped the bleeding in heparinized and non-heparinized groups in 1 second. The AHA fluid (sponge) form stopped the bleeding in the first application in the control group less than 10 seconds and the second time application was not necessary. The bleeding was able to be controlled in the heparinized control group (saline impregnated sponge) by 55 seconds and in the non-heparinized control group by 38 seconds. Conclusion: This study showed that AHA is a highly effective hemostatic agent, which would be beneficial in controlling hemorrhage.
  • Küçük Resim
    Öğe
    Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding
    (Bezmialem Vakif Univ, 2022) Ekici, Hüsamettin; Kumandaş, Ali; Özbaykuş, Abdullah Canberk; Dizdaroglu, Hazal; Midi, Ahmet; Balik, Mehmet Sabri; Yesilada, Erdem
    Objective: The aim of this study is to evaluate the efficacy of the Algan Hemostatic Agent (AHA) available in three different physical form (liquid, powder and sponge absorbed) in the femoral artery incision model in rats. Methods: A total of sixty-four 5-7 weeks old rats were used in the study. Rats were randomly divided into 8 groups each consisting of eight rats (4 groups heparinized and 4 groups non-heparinized). An experimental femoral artery incision was created. As a control, physiological saline absorbed sponge was applied. AHA liquid, AHA powder and AHA sponge absorbed forms were applied to the experimental groups. Results: Upon application to the bleeding sites, all the AHA forms stopped bleeding in a significantly shorter time compared to the control group (p<0.05). In contrast, bleeding in control group could not be controlled within 4 minutes. The best result was in AHA powder form and it was able to control bleeding in the non-heparinized group at 87.5% in the first minute and 12.5% in the second minute. In the heparinize group, the AHA powder form was able to control the bleeding at 62.5% in the first minute and 37.5% in the second minute. Conclusion: This study shows that AHA is a highly effective and promising hemostatic agent in bleeding control.