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    Expressions of cytochrome p450 family and molecular mechanisms in breast cancer
    (Nova Science Publishers, Inc., 2020) Oguztüzün, Serpil; Türk, Bilge Aydin; Yildirim, Isil
    Cytochrome P450 enzymes (CYPs) is an important group of the phase I enzymes family. They protect the metabolism of environmental chemicals, and their genetic variations which are associated with the risk of several forms of cancer including breast cancer. The expressions of individual CYPs were observed in different types of human breast cancers. The changes of these expressions of CYPs may enhance the development and proliferation of breast tumor cells and provoke tumor development through activation of procarcinogens or expression of CYP genes that take place in the biosynthesis of steroids, especially estrogen. Moreover, it affects the etiology of breast cancer and they may also change the response to treatment. That's why the expression of CYP has a critical role in breast cancer. Therefore, this study was carried out to compare the molecular mechanism of CYP family members on breast cancer and the distinct biological processes with each other. © 2020 by Nova Science Publishers, Inc. All rights reserved.
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    Prevention of maternal bacterial transmission on children's dental-caries-development: 4-year results of a pilot study in a rural-child population
    (Pergamon-Elsevier Science Ltd, 2007) Ercan, Ertuğrul; Dülgergil, C. Türksel; Yildirim, Isil; Dalli, Mehmet
    Aim: Dental caries with its bacterial agent is an infectious disease, and shows a vertical transmission. The control of bacterial transmission of Mutans streptococci (MS) from mother to child has been studied, and its results on their children's caries development, and on their siblings' bacterial levels, have been analysed in a field-trial (for 4 years) in rural area. Material and methods: In the same tribe, 8 mothers and their 11 children (test children [TC]), and then (following years) their 9 siblings (test sibling [TSb]), were followed for 4 years. The study started when the TC group had just started to erupt. Test mothers were subjected to a preventive regime. Examination of caries development as well as determination of plaque levels of MS in TC and TSb were carried out annually and at 6-month intervals. At the end of 4 years, two control groups (control children [CC] and control siblings [CSb]) resembling TC and TSb were selected from the other tribe living in the same village, and bacterial data and caries status were compared to both test groups. Results: Microbial data demonstrated that the test children (p < 0.01) and test siblings (p < 0.05) had significantly low bacterial level in plaque samples. Accordingly, TC had significantly low dmf-t and -s number compared to corresponding control group (p < 0.001 for dmf-t, p < 0.0001 for dmf-s). Conclusion: The preventive regimen was applicable in rural southeastern Anatolia, where an introverted life style with a great tribal system is prevailing, any other preventive measures may have been practical or available, and babies are basically cared by mothers. (C) 2007 Elsevier Ltd. All rights reserved.
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    The role of glutation-s-transferase mu1 and teta1 polymorphisms in chronic obstructive pulmonary disease
    (University of Ankara, 2021) Hayat, Buket; Yavuz, Muhsin Selçuk; Sahin, Engin; Dirican, Onur; Sarialtin, Sezen Yilmaz; Yilmaz, Can; Yildirim, Isil
    Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease. Material and Method: There are 36 patients with COPD and 14 control cases, who received the Ethics Committee permission from Polatli Duatepe State Hospital Chest Diseases Department. DNA isolations were made from blood samples from the end of 2019 and the control group. Deletions in GSTM1 and GSTT1 gene regions were examined by qPCR method in COPD patient and control groups. The results of the study were evaluated comparatively by distributing the gene dose according to the Hardy-Weinberg. Result and Discussion: When seen from 36 COPD patients after qPCR analysis, it was found that deletion expressions due to gene doses in all patient groups; 23 individuals (63.8%) in the (+/-) genotype for GST-M1, 13 individuals (26.2%) in the (-/-) genotype. For GST-T1, 14 (%) in the (+/+) genotype 38.8), while deletion was observed with the highest rate, 4 individuals (11.1%) in the (+/-) genotype and 18 individuals (50.1%) in the (-/-) genotype were found. For GST-M1, deletion was observed in 19 individuals (63.3%) in the genotype (+/-) in male individuals, while it was observed in 4 individuals (66.6%) with the same genotype in women. While deletion was not observed in 11 (36.6%) male patients, this rate was observed as 2 (33.4%) in women. In the GST-T1 gene region, there were 10 (33.3%) males in male patients and 4 (66.6%) individuals in female patients with deletion occurring and the frequency of the "null allele" was high (+/+). In the (+/-) genotype, 3 (10%) in males and 1 (16.7%) in females were found. In the genotype where deletion was not observed and the gene was conserved (-/-), 17 (56.7%) individuals were observed in male patients and 1 (16.7%) in female patients. In the case that the gene "null" allele status in the GST-M1 gene region is slightly higher than the GST-T1 gene communication, this situation is thought to be a factor in obstructive pulmonary disease. © 2021 University of Ankara. All rights reserved.