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    Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats
    (Korean Surgical Society, 2022) ozden, Huseyin; Sahin, Yasar; Kilitci, Asuman; Karaca, Gokhan; Gomec, Muhammed; Yildiz, Ahmet; Ucar, Cahit
    Purpose: The etiology and pathogenesis of distal colitis (DC) are poorly understood. Activation of intestinal inflammatory response may lead to intestinal tissue necrosis. Antioxidant and anti-inflammatory agents are among the treatment options. Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA) induced colitis in rats. Methods: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine) groups. DC was induced by intrarectal administration of AA. Statistical comparisons were done by using parameters including colonic tissue IL-1, IL-6, TNF-alpha, and CRP levels. Histopathologic changes of the samples of colonic tissue were scored as mucosal damage score and inflammatory score. A P-value of <0.05 was considered significant. Results: Intrarectal administration of AA leads to increased interleukin and CRP levels. High mucosal damage and inflammatory scores were noted in colitis group animals. Single mesalazine or G. lucidum treatment produced considerably decreased tissue interleukin and CRP levels. The lowest tissue interleukin and CRP levels were noted in the combined treatment group of animals. Mucosal damage and inflammatory scores were found to be significantly low in this group of animals. Conclusion: The intrarectal administration of AA results in an activation of intestinal inflammation and severe mucosal damage in colonic tissue. Single use of mesalazine and G. lucidum treatment decreases the severity of intestinal inflammatory response and mucosal damage. The healing effects of the combined treatment of mesalazine and G. lucidum seem to be more effective than that of separate use in the treatment of DC.
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    Patients' readiness for discharge: Predictors and effects on unplanned readmissions, emergency department visits and death
    (Wiley, 2018) Kaya, Sidika; Guven, Gulay Sain; Aydan, Seda; Kar, Ahmet; Teles, Mesut; Yildiz, Ahmet; Toka, Onur
    AimTo determine the variables that affect patients' perceptions about their readiness for discharge and to elucidate the effects of these perceptions on patient outcomes such as unplanned readmission to the hospital, emergency department visits and death within 30days after discharge. BackgroundIn recent years, it has become even more important to assess patients' readiness for discharge as patients tend to be discharged more quickly. MethodsFor the determination of patients' self-assessment, the Readiness for Hospital Discharge Scale/Short Form was utilized. This 1-year prospective cohort study included 1,601 patients. Data were analysed using a chi-square test, Mann-Whitney U test, univariate logistic regression analysis and multiple logistic regression analysis. ResultsThe results of multiple logistic regression analysis revealed that age, sex, marital status, educational status, presence of someone to help at home after discharge and length of stay were predictors of patients' readiness for hospital discharge. Furthermore, being unready for discharge increased the risk of 30day unplanned readmission and 30day death. ConclusionsConsidering these predictors, patients' perceptions of readiness for discharge must be assessed before deciding to discharge them. Implications for Nursing ManagementNurse managers can consider the predictors of patients' readiness for discharge, thus the risk of unplanned readmission and death may be reduced.