Yazar "Yildiz F." seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Alteration of tumor glucose metabolism after radiotherapy in MCF-7 breast cancer cell lines(UHOD - Uluslararasi Hematoloji Onkoloji Dergisi, 2006) Cengiz M.; Boyunağa H.; Yildiz F.; Ural A.U.; Atahan I.L.Cancer cells utilize anaerobic glycolytic way to compensate their faster metabolism when compared to normal cells. The purpose of this study is to investigate the effect of radiation on tumor metabolism. MCF-7 breast cancer cell lines were divided into 4 groups, including 2 control groups and aerobic and anaerobic study groups (were irradiated 600 cGy by Co-60 teletherapy unit), incubated with radiolabelled glucose for 4 hours. One control group was for aerobic, and the other was for anaerobic group after KCN addition. Radiolabelled CO2 produced by the cells was isolated and collected in specially designed simulation vials. In supernatant the measurements of other end-products of carbohydrate catabolism including lactate, pyruvate, acetate were performed on a liquid scintillation analyzer after they were collected via anion-exchange chromatography. Finally glucose in supernatant was measured enzymatically by glucose oxidase method. Glycogen consumption and lactate production were significantly higher in anaerobic and radiation groups (p<0.01). Whereas CO2 production was significantly higher in control group (p<0.01). Taken all results together radiation lead tumor cells more anaerobic glycolysis with high glycogen consumption, high lactate production and low CO2 production. Radiation itself has led tumor cells to produce energy by anaerobic glycolysis, meaning radiation exposed cells become more hypoxic.Öğe The nationalist-conservative criticism of Turkish Westernism: The Erol Güngör example(Ahmet Yesevi University, 2012) Yildiz F.; Çelik F.Strengthening the frail state was the fundamental issue for the Turkish intellectuals entering the scene in the post-Tanzimat era. In time, the ideas suggested by Turkish intellectuals on state systems and public issues in order to halt the state's decline gained an ideological content. From the final period of the Ottoman era onwards, the Turkish intellectuals, who were influenced by positivist and materialist views originating from the West, became an influential force in reshaping the state and social order from the Tanzimat to the foundation of the Republic. This study reviews the nationalist-conservative intellectual and scholar, Erol Güngör's criticism of the Turkish Westernizationist-reformist intellectuals' approach to public issues and matters of national culture, primarily religion, from the post- Tanzimat era to his own time.Öğe Prevalence of asthmatic smokers: Turkish experience (PASTE Study)(Blackwell Publishing Ltd, 2014) Yildiz F.; Dursun A.B.; Disçi R.; Abadoglu O.; Atalay F.; Ates G.; Ozge C.Background: Although both asthma and smoking are major health problems worldwide, smokers are often excluded from asthma studies. Objectives: It was aimed to verify the prevalence of asthmatic smokers in Turkey and assess the effects of smoking based on clinical parameters, exacerbations and hospitalizations because of lack of national data about the prevalence of smoking among asthmatics. Methods: The study protocol was comprised of a retrospective questionnaire. The asthmatic patients were followed in the outpatient clinics of 18 tertiary hospitals selected from seven different geographical regions in Turkey. We evaluated demographic data, smoking habits, asthma-related diseases, respiratory function and emergency visits. Results: The study population included 1385 patients (M/F: 343/1042), and the mean age was 45.1±14.0 years. Current and former smoking prevalence was 11.4% and 15.1%, respectively. Smoker rates were higher in males and younger asthmatics compared with females and older asthmatics (P<0.01 and P<0.05, respectively). Smoking history ranged from 0.20 to 90 pack-years (the mean was 12.9), and smokers had a higher level of education compared with nonsmokers (P<0.01). Socioeconomically, the most developed region had the highest rate of smoker asthmatics (33.9%; P=0.014). There was an increase in the number of exacerbations in smoker asthmatics during the previous year, but it was not statistically significant (P>0.05). Conclusion: We showed that the smoking prevalence in Turkey was lower in asthmatics (11.4%) compared with the general population (44.5%). Nevertheless, every effort should be made to encourage asthmatics to stop smoking because smoking is a modifiable risk factor for adverse asthma health outcomes. © 2013 John Wiley and Sons Ltd.Öğe Suture anchor tenodesis in repair of distal Achilles tendon injuries(Springer-Verlag France, 2014) Kiliçoğlu O.; Türker M.; Yildiz F.; Akalan E.; Temelli Y.Background: Distal Achilles tendon avulsions are in the form of either bony and nonbony avulsion of Achilles tendon from its calcaneal insertion. Methods: Four patients with distal Achilles tendon avulsions or ruptures which were treated with tendon to bone repair using suture anchors are presented here. Operated leg was immobilized in above-knee cast for 4 weeks while the patient walked non-weight-bearing. Then, cast was changed to below knee, and full weight-bearing was allowed. Patients underwent gait analysis minimum at first postoperative year. Results: Mean American Orthopedics Foot Ankle Society ankle/hindfoot score of patients at last visit was 88.75 (range 85-100), and Achilles tendon total rupture score was 77.75 (range 58-87). Mean passive dorsiflexion of injured ankles (14 ± 5) was lower than uninjured ankles (23 ± 9). All the kinematic parameters of gait analysis were comparable to the uninjured side. Maximum plantar flexion power of injured ankle was 1.40 W/kg, and this was significantly lower than the contralateral side value 2.38 W/kg; (P = 0.0143). Conclusions: There were no visually altered gait or problems in daily life. Suture anchor tenodesis technique of distal Achilles tendon avulsions was successful in achieving durable osteotendinous repairs. © 2012 Springer-Verlag France.
