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Öğe Effects of hormone replacement therapy on renal artery Doppler indices in women with natural menopause(Galenos Yayincilik, 2006) Yucel, Aykan; Kara, Simay Altan; Noyan, Volkan; Sagsoz, Nevin; Cil, Aylin PelinObjective: The aim of our study was to evaluate the effects of three different hormone replacement therapy (HRT) regimens on renal vasculature determined by renal artery Doppler ultrasonography indices in natural menopause. Design: Thirty three postmenopausal women were randomly assigned to receive 0.625 mg conjugated equine estrogen (CEE) + 5 mg medroxyprogesterone acetate (MPA) (Group I), 2 mg estradiol valerate (Group II) or 2.5 mg Tibolon (Group III), respectively. Doppler ultrasound of the left renal interlobar artery was performed for each patient before the beginning and after 70 days of each hormone replacement therapy (HRT). Setting: Kirikkale University, School of Medicine, Department of Gynecology and Obstetrics, and Department of Radiology, Kirikkale, Turkey. Main outcome measures: Renal interlobar artery Doppler indices before and after therapy. Results: Of the thirty three patients, there were 11, 7 and 9 patients who completed the study in group I, II and III, respectively. The mean age of 27 patients who completed the study was 49.44 +/- 4.07. The baseline pulsatility index (PI) and resistivity index (RI) values of the three groups were similar. After 70 days of treatment, there were statistically significant decrease in RI values of group III (p< 0.001) and RI (p=0.047) and PI (p=0.028) values of group II while statistically significant change was not obtained in group I after treatment. Conclusion: Although we may conclude from the results of this small sample sized study that tibolon and estradiol valerate may have favorable effects on renal blood flow and MPA combined with CEE may attenuate the estrogen-induced vascular effects in natural menopause, well designed studies with more patients and long term follow-up are needed to strengthen this judgment.Öğe Effects of L-carnitine on oxidative stress parameters in oophorectomized rats(Taylor & Francis Ltd, 2017) Canbolat, Emel Peri; Sagsoz, Nevin; Noyan, Volkan; Yucel, Aykan; Kisa, UclerAims: The aim of this study was to investigate the antioxidant effects of L-carnitine on the oxidative stress parameters in oophorectomized rats. Methods: Twenty-four female albino Wistar rats were used. Rats were divided into four groups: laparotomy-only (LOSALINE) group, oophorectomy plus L-carnitine 100 mg/kg/day (OXL100) group, oophorectomy plus L-carnitine 500 mg/kg/day (OXL500) group, and oophorectomy-only (OXSALINE) group. Experimental protocol was started on day 21 post-castration. Various dosage forms of L-carnitine or isotonic saline were administered intraperitoneally for 14 consecutive days. Nitric oxide (NO), malondialdehyde (MDA), total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) were evaluated in the tissues including kidney, liver and heart, and sera. Result(s): In the heart tissue samples, there was no difference in the levels of NO, OSI and TOS between the groups. However, MDA levels in OXSALINE group were significantly higher than OXL500 group. On the other hand, there was no statistically significant differences between the groups in terms of levels of NO, MDA, TAS, TOS and OSI in liver, kidney and sera samples. Conclusion(s): Levels of MDA in the heart tissue were significantly higher in OXSALINE group compared to OXL500 group. Thus, it may be suggested that L-carnitine reduces oxidative stress at least in the heart of oophorectomized rats. (C) 2016 Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Öğe Plasma lipocalin-2 levels in pregnancy(Wiley-Blackwell, 2012) Cesur, Semra; Yucel, Aykan; Noyan, Volkan; Sagsoz, NevinObjective. To evaluate plasma levels of lipocalin-2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective casecontrol study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m2 (overweight; n=29) and body mass index <25kg/m2 (n=27), whose gestational ages were between 24 and 28weeks, as study groups and nonpregnant control women with body mass index <25kg/m2 (n=29). Methods. Plasma lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main Outcome Measures. Comparisons among the groups and correlations for lipocalin-2 and the parameters of insulin resistance. Results. Plasma lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m2 compared with the group with pre-pregnancy body mass index <25kg/m2 (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women, especially when pre-pregnancy body mass index was >25kg/m2, and it was correlated with markers of insulin resistance.Öğe Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome(Elsevier Science Inc, 2011) Soyman, Zeynep; Noyan, Volkan; Tulmac, Murat; Yucel, Aykan; Sagsoz, Nevin; Bayrak, Tulin; Cakir, ErdincObjective: To evaluate endothelial function via serum asymmetric dimethylarginine (ADMA) levels, paraoxonase 1 (PON1) activity, and brachial artery flow-mediated dilatation (FMD) in women with polycystic ovary syndrome (PCOS). Design: Prospective case-control study. Setting: University hospital. Patient(s): Thirty patients with PCOS with a mean age of 24.33 +/- 4.50 years and 30 healthy controls matched for body mass index (BMI) and age. Intervention(s): Endothelial function was assessed biochemically with serum ADMA levels and serum PON1 activity and functionally with brachial artery FMD by ultrasonography. Main Outcome Measure(s): Serum ADMA levels, serum PON1 activity, brachial artery FMD, hormonal and biochemical parameters. Result(s): Patients with PCOS had higher levels of free testosterone and insulin, and higher waist-hip ratio and Ferriman Gallwey scores when compared with the controls. Fasting glucose and homeostasis model assessment of insulin resistance were not different between the groups. There was no statistically significant difference in ADMA levels between two groups. Serum PON1 activity and brachial artery FMD were statistically significantly lower in women with PCOS. There was negative correlation between ADMA and PON1 in patients with PCOS. Conclusion(s): Serum PON1 activity and brachial artery FMD, as markers of endothelial dysfunction and cardiovascular risk, were statistically significantly lower in women with PCOS compared with healthy controls matched for age and BMI. Endothelial dysfunction may be seen at earlier ages in patients with PCOS. (Fertil Steril (R) 2011;95:1067-72. (C) 2011 by American Society for Reproductive Medicine.)
