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Öğe The Effect of Different Doses Apelin 13 on Erythrocyte Deformability in Rats(Wiley, 2019) Dursun, Ali Dogan; Ozdemir, Cagri; Comu, Faruk Metin; Kucuk, Aysegul; Arslan, Mustafa…Öğe Effects of Carvacrol on Erythrocyte Deformability in Lower Extremity Ischemia Reperfusion Induced Rats(Wiley, 2018) Comu, Faruk Metin; Ozer, Abdullah; Mardin, Baris; Arslan, Mustafa; Kucuk, Aysegul…Öğe Evaluation of effects of hyperthermic intraperitoneal chemotherapy treatment on erythrocyte deformability(Wiley, 2017) Kalayci, D.; Kucuk, A.; Sen, O.; Comu, F. M.; Arslan, M.; Unal, Y.…Öğe The effects of HES 130 / 0,4 application on erythrocyte deformability in ureteral obstructed rats(Wiley, 2017) Kalayci, D.; Kucuk, A.; Sen, O.; Comu, F. M.; Arslan, M.; Unal, Y.…Öğe Effect of Irisin on Erythrocyte Deformability in Mice with Lower Limb Ischemia Reperfusion Injury(Wiley, 2017) Polat, Yucel; Comu, Faruk Metin; Kucuk, Aysegul; Kartal, Hakan; Dursun, Ali Dogan; Arslan, Mustafa…Öğe Efect of Levosimendan and Nigella Sativa on Erythrocyte Deformability During Myocardial Ischaemia-Reperfusion Injury in Rats(Wiley, 2017) Ozer, Abdullah; Comu, Faruk Metin; Kucuk, Aysegul; Kilic, Yigit; Mardin, Baris; Alkan, Metin; Arslan, Mustafa…Öğe The effects of lornoksikam and intravenous iboprofen in lower extremity ischemia reperfusion injury(Wiley-Blackwell, 2016) Kucuk, A.; Aydin, M. E.; Koc, D. S.; Sivgin, V.; Arslan, M.; Comu, F. M.…Öğe Dendritic cell production from allogenenic donor Cd34+stem cells and mononuclear cells: Cancer vaccine(Oxford Univ Press, 2016) Unal, A.; Birekul, A.; Unal, M. C.; Karakus, E.; Koker, Y.; Ozkul, Y.; Comu, F. M.…Öğe Dendritic Cell Production from Allogeneic Donor Cd34+Stem Cells and Mononuclear Cells; Cancer Vaccine(Amer Soc Hematology, 2016) Unal, Ali; Birekul, Ayse; Unal, Mehmet Cagri; Karakus, Esen; Koker, Yavuz; Ozkul, Yusuf; Comu, Faruk Metin…Öğe Effect of Picroside-2 on Erythrocyte Deformability and Lipid Peroxidation in Rats Subjected to Lower Extremity Ischemia-reperfusion Injury(Wiley-Blackwell, 2015) Comu, Faruk Metin; Kilic, Yigit; Ozer, Abdullah; Kirisci, Mehmet; Dursun, Ali Dogan; Tatar, Tolga; Arslan, Mustafa…Öğe Effect of Exenatide on Liver in an Iron Overload Rat Model(Wiley-Blackwell, 2015) Kuskonmaz, Serife Mehlika; Dursun, Ali Dogan; Kara, Halil; Sarikaya, Badegul; Bayraktar, Aslihan Cavunt; Kucuk, Aysegul; Arslan, Mustafa…Öğe The Effect of Picroside-2 on Erythrocyte Deformability and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats subjected to Left Anterior Descending Artery-Ischemia reperfusion (conferenceObject)(Wiley-Blackwell, 2015) Comu, Faruk Metin; Polat, Yucel; Ozer, Abdullah; Erer, Dilek; Kirisci, Mehmet; Dursun, Ali Dogan; Arslan, Mustafa…Öğe Effects of iron overload and exenatide on erythrocyte deformability in a rat model (conferenceObject)(Wiley-Blackwell, 2015) Kuşkonmaz, Şerife Mehlika; Kara, Halil; Çomu, Faruk Metin; Küçük, Ayşegül; Arslan, Mustafa…Öğe The effect of peritoneal wrapping on colonic anastomosis healing in rats with impaired wound healing due to superior mesenteric artery occlusion(John Wiley & Sons Ltd, 2010) Emirdogan, M.; Daphan, C.; Agalar, F.; Aydınuraz, K.; Çomu, F. M.…Öğe Gender-related alerations in erythrocyte mechanical activities under desflurane or sevoflurane anesthesia(Ios Press, 2008) Yerer, Muekerrem Betue; Aydogan, Sami; Comu, Faruk MetinAlterations in erythrocyte mechanical activities under the influence of anesthesia have been observed and discussed among the responsible factors for the deterioration of tissue and organ perfusion related to anesthetic procedures. 21 female and 17 male Swiss Albino rats were used. Female (f) and male ( m) rats were divided into 3 groups; control (f (n = 7); m (n = 5)), sevoflurane treated group (f (n = 7); m ( n = 5)), desflurane treated group ( f ( n = 7); m (n = 7)). 2% of sevoflurane or 6% desflurane were applied to the rats with inhalation in an adjustable cage for one hour. The deformability indexes of the erythrocytes were measured by a laser diffractometer (Myrenne Rheodyne SSD). Sevoflurane anesthesia has improved the deformability of erythrocytes in male rats (p < 0.05) whereas there were not any significant changes in female rats. Desflurane has improved the deformability of erythrocytes in both gender significantly (p < 0.05). Volatil anesthetic agents sevofluran and desflurane has improved the mechanical properties of the erythrocytes in male rats compared to their controls. However, these changes were not significant with sevoflurane in females. The results in male rats may be due to the effects of testosterone on the flexibility of the erythrocytes leading them to tolerate to the environmental changes. These results reveal that the inhalation anesthetics like sevoflurane and desflurane are appropriate anesthetics which can improve the deformability of erythrocytes during surgery.Öğe The red blood cell deformability alterations under desfluran anesthesia in rats(Ios Press, 2006) Yerer, Mükerrem Betül; Aydogan, Sami; Çomu, Faruk Metin; Arsland, Mustafa; Güneş-Ekinci, Işın; Kurtipek, Ömer; Ünal, YusufGeneral anesthesia, either with inhalation or through nonvolatile anesthetics, is known to affect the overall cardiovascular function as well as the microcirculatory hemodynamics. In this study, the effects of desfluran anesthesia on the red blood cell deformability of young and old rats are investigated. 33 male rats were used in the study and the rats were divided into two groups according to their age (young and old) comprising of two subgroups in each. First group was the young control (n=5), the second was the young group treated with desfluran (n=7), the third group was the old control (n=7) and the last group was the old group treated with desfluran (n=7). %6 of desfluran was applied to the rats with inhalation in an adjustable cage for one hour. The elongation indexes of the erythrocytes were measured by a laser diffractometer (Myrenne Rheodyne SSD). Deformability indexes of red blood cells were significantly increased with desfluran in young rats (p=0.042) whereas they were significantly decreased in old rats (p=0.004) with desfluran application compared with their controls. When we compared the young and old control groups, the deformability indexes were significantly higher in old ones (p < 0.001). However, there was no significant difference between the old and the young desfluran applied groups. The volatile anesthetic agent desfluran impairs the deformability of erythrocytes in old rats compared to their controls, whereas it has the opposite effects on young ones. This may be due to the alterations in membrane structure with age. These results reveal that the inhalation of anesthetics like desfluran may cause more serious problems in the elder people during the surgery and may influence their hemodynamic parameters.Öğe The influence of sevoflurane anesthesia on the rat red blood cell deformability(2006) Aydoğan, Sami; Yerer, Mükerrem Betül; Çomu, Faruk Metin; Arslan, Mustafa; Güneş-Ekinci, Işın; Ünal, Yusuf; Kurtipek, ÖmerAlterations in blood rheology under the influence of anesthesia have been observed and discussed among the responsible factors for the deterioration of tissue and organ perfusion related to anesthetic procedures. Sevoflurane is one of the volatil anesthetics which is being used very common in surgery. In this study, the effects of sevoflurane anesthesia were investigated in different age groups of rats. 22 male rats were used in the study and the rats were divided into two groups according to their age (young and old) comprising of two subgroups in each. First group was the young control (n = 5), the second was the young group treated with sevoflurane (n = 5), the third group was the old control (n = 7) and the last group was the old group treated with sevoflurane (n = 5). %2 of sevoflurane was applied to the rats with inhalation in a adjustable cage for one hour. The deformability indexes of the erythrocytes were measured by a laser diffractometer (Myrenne Rheodyne SSD). Deformability indexes of red blood cells were significantly decreased with sevoflurane in old rats (p = 0.028) whereas it had not any significant effect in young group compared with their controls. When we compared the young and old control groups, the deformability indexes were significantly higher in old ones (p < 0.001). However, there were not any significant difference between the old and the young sevoflurane applied groups. A volatil anesthetic agent sevoflurane has impaired the deformability of erythrocytes in old rats compared to their controls, whereas it had not any significant effect in young ones which may be due to the flexibility of the young erythrocytes leading them to tolerate to the environmental changes. These results reveal that the inhalation anesthetics like sevoflurane may cause more serious problems in the elder people and their hemodynamic parameters should be checked more seriously during the surgery. © 2006 - IOS Press and the authors. All rights reserved.
