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Being Nutritionally At-Risk: Its Effect on Health Expenses and Length of Stay In Hospital
(Mattioli 1885, 2022) Güngör, Anıl Evrim; Kılınç, Fatma Nişancı; Alparslan, İrem; Cakır, Biriz; Asil, Esma; Esatoglu, A. Ezel; Yavuz, Yasemin
Objective: Hospital malnutrition is a critical, cost-increasing public health problem that is common in many countries. The study aimed to evaluate the effect of being nutritionally at risk on health expenses and length of stay (LOS) in hospital. Material and Method Nutritional Risk Screening-2002 (NRS-2002) was used to screen 1069 adult patients on admission day. Patients' anthropometric measurements, unintentional weight loss, hand grip strength (HGS), cancer diagnosis, as well as LOS were recorded. Health expenses for each patient was obtained from hospital billing system. Results: Of the patients, 19.1% had NRS-200233 (nutritionally at risk) which was more frequent among male patients (61.8%) than female patients (38.2%) (p<0.001). The odds of being nutritionally at risk increased by 1.029 times with one year increase in age (p<0.05). The median of HGS was lower in patients with NRS-200233 (p<0.05). Patients without nutritional risk (NRS-2002<3) had a LOS of 7.65 +/- 7.61 days, while corresponding figure was 16.5 +/- 15.64 days for patients with NRS-200233 (p<0.001). Patients' health expenses with NRS-2002<3 and NRS-200233 were $384.19 and $873.89, respectively (p<0.01). One percent increase in involuntary weight loss and one unit decrease in HGS resulted in $2588 and $1066 increase in average expenses, respectively (p<0.05). The odds of becoming NRS-2002 >= 3 increased 1.566 times with 1% increase of involuntary weight loss (p<0.001). Cancer patients whose average LOS was 4.5 days longer had 4.93 times increased risk of developing nutritional risk during hospital stay (p<0.001). Conclusion: Nutritional status of patients should be assessed during hospitalization. Patients with nutritional risk have higher total costs and stay longer in the hospital than the patients with no risk.
Gençlerin Beslenme ve Gıda Güvenliğine İlişkin Bilgi ve Davranışlarının Değerlendirilmesi
(2017) Şanlıer, Nevin; Uzunlar, Elif Adanur; Uyar, Gizem Özata; Elibol, Elif; Coşkun, Ayfer Beyaz; Erdoğan, Rukiye; Bozbaş, Esra
Bu çalışma Gazi Üniversitesi'nin farklı fakültelerinde okuyan öğrencilerin beslenme ile gıda güvenliği bilgisi, alışkanlıkları öz yeterlilik ve fiziksel aktivite durumlarını değerlendirmek amacıyla yapılmıştır. Çalışmaya Gazi üniversitesinin sağlık bilimleri (n=140), sosyal bilimler (n=46) ve fen bilimlerinde (n=64) öğrenim gören 68'i erkek, 182'si kız toplam 250 öğrenci dahil edilmiştir. Öğrencilere Turconi ve arkadaşlarının (2003) geliştirdiği toplam 9 bölüm ve 84 sorudan oluşan bir ölçek uygulanmıştır. Veriler SPSS 22.0 programıyla değerlendirilmiştir. Araştırmaya katılan öğrencilerin yaş ortalaması 19.74±1.84 yıldır. Şişmanlığın belirlenmesinde kullanılan beden kütle indeksi (BKİ) değerinin ortalaması erkeklerde ve kızlarda sırasıyla 22.55±2.75 ve 21.25±2.99 kg/m2 'dır. Sağlık bilimlerinde okuyan öğrencilerin beslenme alışkanlığı (BA), sağlıklı/sağlıksız beslenme alışkanlıkları ve besinler (SSBAB), beslenme bilgisi (BB) ve gıda güvenliği bilgisi (GGB) puanları fen ve sosyal bilimlerde okuyan öğrencilerden anlamlı derecede yüksektir. Bütün alt gruplar cinsiyete göre değerlendirildiğinde kız öğrencilerin puanlarının erkeklerden yüksek olduğu ve bu farkın öz yeterlilik haricinde diğer bütün alt gruplarda anlamlı olduğu tespit edilmiştir (p<0.05). Sadece erkeklerin fiziksel aktivite puanları kızlara göre daha yüksektir (p<0.05). Öğrencilerin BKI değerleri artıkça gıda güvenliği bilgisi (GGB) ve sağlıklı/sağlıksız beslenme alışkanlıkları bilgisi (SSBAB) puanlarının düştüğü saptanmıştır (p<0.05). Araştırmada sağlık bilimlerinde okuyan öğrencilerin beslenme bilgi ve alışkanlıklarının diğer bilimlerde okuyan öğrencilerden daha iyi olduğu sonucuna ulaşılmıştır
Zayıflama Diyetlerinde Kullanılan Balık Yağının Vücut Bileşimi, Plazma Leptin Düzeyleri ve Kan Basıncı Üzerine Etkisi
(2013) Kılınç, Fatma Nişancı; Besler, Tanju H.
Amaç: Bu çalışma zayıflama diyetine eklenen balık yağının vücut bileşimi, plazma leptin düzeyi ve kan basıncı üzerindeki etkisini değerlendirmek amacıyla yapılmıştır. Bireyler ve Yöntem: Çalışmada beden kütle indeksleri 30-35 kg/m2 olan premenapozal 40 kadın 2 gruba ayrılmıştır. Araştırma grubuna zayıflama diyeti ve 1 g/gün balık yağı, kontrol grubuna zayıflama diyeti verilmiştir. Çalışmanın başında ve 12. haftada vücut bileşimi, serum leptin düzeyi ve kan basınçları değerlendirilmiştir. Bulgular: Çalışmaya alınan bireylerin vücut ağırlığı ve beden kütle indeksi, bel çevresi ve vücut yağ yüzdesinde başlangıca göre önemli azalma saptanmıştır (p<0.05). Ancak gruplar arasında istatistiksel olarak önemli fark bulunmamıştır (p>0.05). Araştırma ve kontrol grubundaki bireylerin başlangıç ile 12. haftadaki serum leptin düzeyi arasındaki azalma ve gruplar arasındaki farkın istatistiksel olarak önemli olduğu saptanmıştır (p<0.05). Her iki grupta bireylerin diastolik ve sistolik basınç değerlerinde görülen azalmanın istatistiksel olarak önemli (p<0.05), gruplar arasındaki farkın ise önemli olmadığı görülmüştür (p>0.05). Sonuç: Obez bireylerde zayıflama diyetine eklenen balık yağı plazma leptin düzeyini düşürmüş ancak antropometrik ölçümler ve kan basıncı üzerinde önemli bir değişiklik oluşturmamıştır. Balık yağının yararlı etkilerini görebilmek için bu alanda daha uzun periyodlarda dozu arttırılmış daha ileri çalışmalarla elde edilecek olan kesin kanıtlara gereksinim duyulmaktadır.
Association of mediterranean diet and anthropometric measures with quality of life in coronary artery disease patients
(ARAN Ediciones S.A., 2019) Uyar Gizem Özata; Coşkun Ayfer Beyaz; Gökalp Gökhan; Köksal Eda
Introduction: the Mediterranean diet (MD) and ideal body weight are associated with a reduction in the risk of chronic diseases, but their association with health-related quality of life (HRQL) is not clear. Objective: the aim of this study was to assess the association between adherence to MD and the HRQL and anthropometric measurements in coronary artery disease patients. Methods: this cross-sectional study was carried out in 55 women and 84 men who were diagnosed with coronary artery disease by a physician. Anthropometric indices were measured, MD adherence was evaluated with a 14-item questionnaire and the 36-Item Short Form Health Survey (SF-36) was used for HRQL. Results: mean age in males was 63.0 ± 9.7 years and mean age in females was 63.1 ± 10.1 years. Prevalence of overweight and obesity was 53.5% and 40.5%, respectively, in men and 14.5% and 83.6%, respectively, in women. Adherence to the MD was assessed and the median values were found statistically higher in male patients (p < 0.05). A significant positive correlation was found between MD and all physical component summary (PCS, its subscale) and most mental component summary (MCS) (except emotional role, social health subscale) (p < 0.05). Inverse significant associations were found between BMI, waist circumference, waist/height ratio, percent of body fat and both PCS and MCS (including most subscales). Conclusion: adoption of healthy dietary habits (adherence to the Mediterranean diet) by the participants and optimal anthropometric measurements may be considered as a possible contributor to HRQL. © 2019 SENPE y and Arán Ediciones S.L.
The relationship between sleep duration, sleep quality and dietary intake in adults
(SPRINGER JAPAN KK, 2020) Cakir, Biriz; Kilinc, Fatma Nisanci; Uyar, Gizem Ozata; Ozenir, Ciler; Ekici, Emine Merve; Karaismailoglu, Eda
To determine the relationship of specific macro- and micro-nutrients and food groups with sleep duration and sleep quality in adults. This cross-sectional descriptive study was conducted on 2446 adults aged between 20 and 64 years in Turkey. The participants' socio-demographic characteristics, anthropometric measurements, and dietary intake (24-h recall) were taken. The Pittsburgh Sleep Quality Index was used to assess sleep quality. In the study, 48.9% of the participants were male and 51.1% were female, with an average age of 38.7 +/- 12.70 years. Total protein, meat, and processed meat product consumption rates of long sleepers were found to be lower than those of normal sleepers (p < 0.05). Saturated fat intake of short sleepers was higher than that of long sleepers (p < 0.018). Participants with good sleep quality were found to consume higher carbohydrate, fiber, beta-carotene, vitamin E, thiamine, vitamin B-6, total folate, vitamin C, calcium, magnesium, potassium, and iron compared to those with poor sleep quality (p < 0.05). When examined in terms of food groups, fruit consumption was higher in individuals with good sleep quality compared to those with poor sleep quality (p < 0.05). In this study, some macro- and micro-nutrients of the diet were found correlated with sleep duration and quality. Mechanisms mediating the relationship between sleep duration and dietary intake are multi-factorial. Because of the differences in appetite-related hormones, such as leptin and ghrelin, and hedonic factors, future studies will benefit from assessing sleep duration/quality and dietary intake.
Evaluation of obesity in university students with neck circumference and determination of emotional appetite
(Mattioli 1885, 2019) Kilinc, Fatma Nisanci; Cakir, Biriz; Durmaz, Sevinc Eser; Ozenir, Ciler; Ekici, Emine Merve
Objective: In this study, it was aimed to evaluate obesity in university students with neck circumference and other anthropometric measurements and to determine their emotional appetite. Method: The study was conducted within the scope of Scientific Research Projects Coordination Unit of Kirikkale University in June-December 2017 in June-December 2017 term and 4873 students were reached. A questionnaire consisting of descriptive information and emotional appetite scale was applied to students and their obesity status were determined by taking anthropometric measurements. Results: Students consist of 56.3% females and 43.7% males. Mean body mass index (BMI) is 23.62 +/- 3.03 kg/m(2) in males and 21.66 +/- 3.08 kg/m(2) in females (p<0.001). Mean neck circumference is 37.50 +/- 2.49 cm in males and 32.18 +/- 3.51 cm in females (p<0.001). According to student's BMI, 18.5% are overweight and obese, to neck circumference 36.6% are obese, and to waist circumference 22.4% are in the risk and high-risk group. 65.8% of males and 19.4% of females are obese according to neck circumference (p<0.001). Waist circumference/height ratio of males is 0.478 +/- 0.054 while that of females is 0.452 +/- 0.053. Central obesity was observed in 30.2% of males and 16.3% of females (p<0.001). A positive correlation was found between body weight, BMI, waist circumference, wrist circumference, waist/height ratio and neck circumference. Emotional appetite status of students and values of total positive scores are different from others in at least one of BMI groups (chi(2) =14.503; p=0.002). Total positive scores of thin students are higher than those who are overweight and obese (p<0.001). Total score in negative emotions/conditions is high in students who are obese according to neck circumference (Z=4.539; p<0.001). In negative and positive emotions/conditions, median score of total emotional appetite scale of males is higher than that of females (p<0.001). Conclusion: According to neck circumference, it is determined that obesity more common in males than females, males' appetites increase more than females' in positive and negative situations, and overweight and obese students exhibit more eating behaviour when they experience negative emotions.
Fatty acid transport receptor soluble CD36 and dietary fatty acid pattern in type 2 diabetic patients: a comparative study
(Cambridge Univ Press, 2018) Ekici, Merve; Kisa, Ucler; Durmaz, Senay Arikan; Ugur, Elif; Nergiz-Unal, Reyhan
Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30-65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0.05), the consumption of olive oil in the type 2 DM group was lower than the control group (P<0.05). Mean blood glucose, insulin, insulin resistance, TAG and sCD36 levels were determined to be higher in the type 2 DM group (P<0.05). However, there was no correlation between sCD36 levels and homeostatic model assessment of insulin resistance (HOMA-IR) value, blood insulin and TAG levels, waist circumference, dietary fatty acid pattern and food preferences in the type 2 DM group (P>0.05). Crucially, elevated sCD36 levels increased the type 2 DM risk (OR 1.21, P<0.05). In conclusion, sCD36 level may be a possible biomarker, independent from the dietary fatty acid pattern, for type 2 DM owing to its higher levels in these patients. Therefore, the new insights make CD36 attractive as a therapeutic target for diabetes.
Immobilization of horseradish peroxidase on electrospun poly(vinyl alcohol)-polyacrylamide blend nanofiber membrane and its use in the conversion of phenol
(Springer, 2018) Temoçin, Zülfikar; İnal, Murat; Gökgöz, Murat; Yigitoğlu, Mustafa
Electrospun nanofibers, with their porous structures, high surface-to-volume ratio, and good mechanical properties, are used as a support material for enzyme immobilization. In this study, the poly(vinyl alcohol) and polyacrylamide bicomponent (PVA-PAAm) nanofibers were fabricated via the electrospinning method. Synthesized PAAm was characterized with size exclusion chromatography (SEC). Nanofibers were characterized by fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and scanning electron microscope (SEM). DSC and TGA analyses showed that the nanofibers were more durable than PVA and PAAm polymers. SEM images demonstrated that all nanofibers possessed uniform and smooth structures (average diameter about 300 nm). FTIR results have shown that PAAm successfully participates in nanofiber structure. The produced nanofibers were used as support material for covalent immobilization of horseradish peroxidase (HRP). The optimum temperature for free HRP was 45 A degrees C, whereas it was 50 A degrees C for the immobilized enzyme. The immobilized HRP showed better storage and thermal stability than free HRP. The kinetic parameters (K (m) and V (max)) were found to be 2.42 mM and 0.027 U for the immobilized HRP and 1.86 mM and 0.079 U for the free HRP, respectively. The immobilized enzyme could be used effectively for 25 cycles with 54% retention of the activity. The immobilized HRP was also used for the conversion of phenol. Phenol removal was found to be about 29.68% at 180 min in real wastewater. The novel PVA-PAAm nanofibrous material was successfully used as a support material for covalent immobilization of HRP. Immobilized enzymes such as oxido-reductases onto the PVA-PAAm bicomponent nanofiber could be recommended in the treatment of organic pollutants in industrial effluents.
Determination of obesity, stunting, and nutritional habits in disabled children and adolescents
(Mattioli 1885, 2018) Kilinc, Fatma Nisanci; Cakir, Biriz; Ekici, Merve; Ozenir, Ciler
Objective: This study was conducted to determine obesity, stunting and nutritional habits in children and adolescents with disabilities. Methods: The study was carried out in 612 disabled children and adolescents in a 2-19 age group enrolled in 8 special education practice and rehabilitation institutions in Kirikkale city center in Turkey. The general characteristics and eating habits of the participants were examined and body mass indexes (BMI) were calculated (n=527) to determine obesity and stunting. Results: Of the participants (n=612), 39.2% were female and 60.8% were male, of whom 39.4% were mentally disabled, 37.1% were physically disabled, 12.3% were mentally and physically disabled, and 11.3% were suffering other types of disabilities (speech disorders, learning disability, etc.). Of the participants (n=527), 18.8% were overweight and 17.8% were obese. The rate of overweight (Male:18.5%, Female:19.2%) and obesity (Male:19.1%, Female:15.9%) was higher in males compared to females (p>0.05). The correlation between BMI classification and disability type, disability level, and income level was not statistically significant (p>0.05). The rate of stunting was 24.5%, which was lower in males compared to females (Male: 20.4%, Female: 30.8%) (p>0.05). There was no statistically significant difference between height-for-age classifications and the type of disability (p>0.05); however, the difference between disability level and income level was significant (p<0.05). It was observed that 50.0% of the participants had eating problems and 45.5% had the habit of skipping breakfasts. Conclusion: In this study, it was observed that overweight, obesity, and stunting are very high in disabled children and adolescents. This field warrants further research.
Reliability and Validity Study of the Turkish Version of Child and Adolescent Social Support Scale for Healthy Behaviors
(Elsevier Science Inc, 2018) Albayrak, Sevil; Cakir, Biriz; Kilinc, Fatma Nisanci; Vergili, Ozge; Erdem, Yurdagul
Purpose: The purpose of this study is to investigate adaptation, validity, and reliability of the Turkish version of the Child and Adolescent Social Support Scale for Healthy Behaviors (CASSS-HB). Methods: The CASSS-HB was translated using translation and back-translation. This was a methodological study conducted with 860 students (11-14 years old). Content and construct validity were assessed to test the validity of the CASSS-HB. Exploratory and confirmatory factor analysis of the scale was performed and the reliability of the scale over time (the test-retest method) was examined. Results: Psychometric analyses of the Turkish version of the CASSS-HB indicate high reliability and good content and construct validity. Conclusions: It can be seen that the items comprising the scale appear to be acceptably capable of measuring the variable of social support in terms of healthy behavior in children and adolescents. Healthcare professionals can thus use the scale for determining the degree of social support students of the ages 11-14 receive in terms of developing healthy behavior. (C) 2018 Korean Society of Nursing Science, Published by Elsevier Korea LLC.
Maternal Low Quality Protein Diet Alters Plasma Amino Acid Concentrations of Weaning Rats
(Mdpi, 2015) Çetin, Arzu Kabasakal; Daşgın, Halil; Güleç, Atila; Onbaşılar, İlyas; Akyol, Aslı
Several studies have indicated the influence of a maternal low protein diet on the fetus. However, the effect of a maternal low quality protein diet on fetal growth and development is largely unknown. Wistar rats (11 weeks old) were mated and maintained on either a chow diet with 20% casein (n = 6) as the control group (C), or a low quality protein diet with 20% wheat gluten (n = 7) as the experimental group (WG) through gestation and lactation. Maternal body weights were similar in both groups throughout the study. Birth weights were not influenced by maternal diet and offspring body weights during lactation were similar between the groups. Offspring's plasma amino acid profiles showed that plasma methionine, glutamine and lysine were significantly lower and aspartic acid, ornithine and glycine-proline were significantly higher in the WG. Plant based protein comprises an important part of protein intake in developing countries. It is well-known that these diets can be inadequate in terms of essential amino acids. The current study shows differential effects of a maternal low quality protein diet on the offspring's plasma amino acids. Future studies will examine further aspects of the influence of maternal low quality protein diets on fetal growth and development.
Adsorption of chromium(VI) metal ions from aqueous solution using hexagonal ZnO particles: Equilibrium, kinetic and thermodynamic modelling studies
(Wiley, 2014) Erduran, Nuran; Gokgoz, Murat; Ada, Kezban
Zinc oxide powders having hexagonal plate particles were prepared by homogeneous precipitation from boiling aqueous solutions that contained excess urea and 0.075 (Z075) and 0.300 (Z300) M Zn2+. The equilibrium, kinetic and thermodynamics of the adsorption of chromium (VI) from aqueous solution onto Z075 and Z300 were investigated. Thermodynamic parameters and K-# equilibrium constant of activation were calculated. Langmuir, Temkin and Dubinin-Radushkevich (D-R) isotherm models were used to describe the adsorption of Cr(VI) onto ZnO powders. The monomolecular adsorption capacity of Z075 and Z300 was determined as 980 and 1050mgg(-1) for Cr(VI), respectively.
β-Glucan and Dark Chocolate: A Randomized Crossover Study on Short-Term Satiety and Energy Intake
(Mdpi, 2014) Akyol, Asli; Dasgin, Halil; Ayaz, Aylin; Buyuktuncer, Zehra; Besler, H. Tanju
Aim: The aims of this study were to adapt a traditional recipe into a healthier form by adding 3 g of oat -glucan, substituting milk chocolate to dark chocolate with 70% cocoa, and to examine the effect of these alterations on short-term satiety and energy intake. Materials and Methods: Study subjects (n = 25) were tested in a randomized, crossover design with four products closely matched for energy content. Four different versions of a traditional recipe including milk chocolate-control (CON), oat -glucan (B-GLU), dark chocolate (DARK) or oat -glucan and dark chocolate (B-GLU + DARK) were given to subjects on different test days. After subjects were asked to report visual analog scale (VAS) scores on sensory outcomes and related satiety for four hours ad libitum, lunch was served and energy intake of individuals was measured. Results: VAS scores indicated that none of the test foods exerted an improved effect on satiety feelings. However, energy intake of individuals during ad libitum lunch was significantly lower in dark chocolate groups (CON: 849.46 +/- 47.45 kcal versus DARK: 677.69 +/- 48.45 kcal and B-GLU + DARK: 691.08 +/- 47.45 kcal, p = 0.014). Conclusion: The study demonstrated that substituting dark chocolate for milk chocolate is more effective in inducing satiety during subsequent food intake in healthy subjects.
Diet and physical activity interventions do have effects on body composition and metabolic syndrome parameters in overweight and obese adolescents and their mothers
(Turkish J Pediatrics, 2013) Nişancı-Kılınç, Fatma; Çağdaş, Deniz N.
To determine the effects of lifestyle intervention and diet on body composition, anthropometric measurements, and metabolic syndrome (MS) in obese and overweight adolescents and their mothers, a diet and lifestyle intervention program was administered for 16 weeks to 19 9-17-year-old (12.52 +/- 2.85 years) adolescents (female/male, 8/11) with a body mass index (BMI) value over the 90th percentile; hemoglobin (Hb) A1C, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fibrinogen, and C-reactive protein levels of the adolescents and anthropometric measurements of the mothers were compared. In some of the anthropometric values (body weight (BW), BMI, waist circumference (WC), skinfold thicknesses, body fat tissue, and lean tissue mass), a statistically significant difference was observed in pre-and post-application measurements (p<0.05). There was a significant difference in pre-and post-application values of systolic and diastolic blood pressure and some biochemical parameters (uric acid, total cholesterol, high density lipoprotein, low density lipoprotein, triglyceride, and HOMA-IR) (p<0.05); however, there was no significant difference in pre-and post-application values of fasting blood glucose, aspartate transaminase, alanine transaminase, albumin, HbA1C, fasting insulin, and fibrinogen (p>0.05). MS was observed in 52.6% of the participants at baseline, and this rate was found as 15.8% based on the measurements carried out at week 16, which is a statistically significant decrease (p<0.05). There was a statistically significant difference in pre-and post-study values of BW, BMI, body fat mass, basal metabolic rate, WC, hip circumference, hip/waist, and skinfold thickness in mothers. A 16-week diet and lifestyle intervention program for overweight and obese adolescents involving their mothers resulted in significant improvement in obesity and MS treatment.
Delayed presentation of post-traumatic diaphragmatic hernia with gastric volvulus: a case report
(Turkish Assoc Trauma Emergency Surgery, 2010) Yakaryilmaz, Fahri; Banli, Oktay; Altun, Hasan; Guliter, Sefa
Post-traumatic diaphragmatic hernia complicated by gastric volvulus may manifest immediately or several years after the incident. Delayed presentation of traumatic diaphragmatic hernia with gastric volvulus is relatively unusual. We report a 28-year-old male patient who admitted with gastric volvulus due to traumatic diaphragmatic hernia after sustaining a knife wound to the left lower chest one year before presentation. The patient has been followed without any symptom for two years since the diaphragmatic hernia was repaired by primary suture plication.
Celiac disease prevalence in patients with iron deficiency anemia of obscure origin
(Turkish Soc Gastroenterology, 2009) Ucardag, Derya; Guliter, Sefa; Ceneli, Ozcan; Yakaryilmaz, Fahri; Atasoy, Pinar; Caglayan, Osman
Background/aims: Anemia, especially due to iron deficiency, is a frequent feature in celiac disease. In this study, we aimed to define the prevalence of celiac disease in Turkish patients with iron deficiency anemia of obscure origin. Methods: One thousand four hundred and eighty-six consecutive patients with iron deficiency anemia were evaluated for etiology. Of those, 77 patients were found to have iron deficiency anemia of obscure origin. Sera from 77 patients with iron deficiency anemia of obscure origin and 119 healthy controls were tested for IgA and IgG tissue transglutaminase (tTG) antibodies by ELISA. Endoscopic mucosal biopsies were taken from the second part of the duodenum in these patients. Histopathologic examination results of patients were stratified according to Marsh classification. Results: IgA and IgG class anti-tTG antibodies were found positive in 6 (7.8%) and 3 (3.9%) patients with iron deficiency anemia of obscure origin, respectively. Three patients had only IgA anti-tTG and 3 had both IgA and IgG anti-tTG antibodies. In the control group, 1 subject was positive for both IgA and IgG anti-tTG antibodies (0.7%). Six patients (7.8%) and 1 control subject (0.8%) had histopathologic findings of celiac disease (p=0.02). Conclusions: Patients with iron deficiency anemia of obscure origin had increased prevalance of celiac disease. Our study results suggest that serological screening may be recommended for early detection of celiac disease in patients with iron deficiency anemia of obscure origin.
A case report of gastric antral vascular ectasia (watermelon stomach) as a rare cause of gastrointestinal bleeding
(2005) Leventoğlu, Sezai; Güliter, Sefa; Akyürek, Nusret; Menteş, Bülent; Yakaryılmaz, Fahri; Dursun, Ayşe; Görgül, Ahmet
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