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  • Öğe
    Does Generalized Linear Model Support Functional Default Mode Network Studies
    (Aves, 2019) Kocak, Orhan Murat; Ozdemir Rezaki, Hatice; Turkel, Yakup; Inal, Mikail; Buturak, Sadiye Visal
    Introduction: A growing body of research has emerged on the resting state and the default mode of the brain. Functional connectivity studies, which lately dominate this research area, have confirmed that regions such as the cortical mid-line structures, as well as parietal-temporal regions are tightly interconnected within the default mode network (DMN). However, little is known about the activity patterns of resting state related brain regions detected in fMRI studies using the generalized linear model (GLM) in a whole brain analysis. The aim of the current study was to investigate the activity changes among brain regions identified through GLM during the transition from task to rest and the prolongation of rest. Methods: A picture imagination task, as a controlled thought content task, was used in order to minimize confounding factors such as a visual stimulus or a motor response. Results: The present study revealed a consistent fluctuating activation pattern of the dorsal anterior cingulate cortex (dACC), the posterior cingulate cortex (PCC), thalamus, primer motor area (PMA), insula, brain stem and bilateral putamen during the transition from task to the early phase of the resting state and the prolongation of the resting state. All regions showed increased activation during the detachment from task. However, this increased activation was not sustained during the extension of rest, replaced with a decreased activation at the late phase of rest. The increased activation of resting state regions might help with the detachment from the current task. Among these regions dACC, insula and putamen were correlated in all conditions. Conclusion: These findings underline the importance of the activation increase of the cortical mid-line regions and insula in the transition from task to the resting state.
  • Öğe
    The Evaluation of Attachment Style and Temperament in Patients With Hyperemesis Gravidarum: Does the Idea That Hyperemesis Gravidarum Has a Psychological Origin Persist?
    (Kowsar Publ, 2018) Sayan, Cemile Dayangan; Buturak, Sadiye Visal
    Background: Hypremesis Gravidarum (HG) is a common disease in pregnancy during the first trimester. Patients suffering from HG commonly present with dehydration, nutritional depletion, electrolyte imbalance, and the loss of at least 5% of body weight. Although the psychological etiology of HG is not clear, it has been shown that psychiatric symptoms are extensively present in patients with HG. Objectives: The aim of this study was to investigate the relationship between temperament, attachment style and hyperemesis gravidarum. Materials and Methods: This case-control study was conducted at Kirikkale University Hospital in Kirikkale, Turkey, between May 2015 and May 2017. A total of 98 pregnant women suffering from HG in their first trimester of pregnancy (HG group) and 95 healthy pregnant women in their first trimester of pregnancy (control group) were included in the study. Adult attachment styles were determined as secure, fearful, preoccupied, and dismissing. The evaluation of temperament was done using the TEMPS-A scale. Results: The mean secure attachment style score in the HG group was 3.9 +/- 0.9 and significantly lower than the mean attachment style score (4.6 +/- 1.1) in the control group (P = 0.001). In the TEMPS-A scale, patients with HG showed significantly higher mean depressive (9.7 +/- 3.8) and mean anxious scores (13 +/- 2.3) than those of the control group (6.6 +/- 2.9 and 8 +/- 0.9, respectively) (P = 0.001 and P = 0.040, respectively). Conclusions: This study revealed that HG patients had more common depressive and anxious temperament characteristics and lower secure attachment style than non-HG patients. Due to the fact that attachment and temperament styles are relatively stable throughout life, we thought that psychiatric problems may play a role on development of HG.
  • Öğe
    The effect of temperament on the treatment adherence of bipolar disorder type I
    (Taylor & Francis Ltd, 2016) Buturak, Sadiye Visal; Emel, Erdogan Bakar; Kocak, Orhan Murat
    Background and aims: Treatment adherence is one of the most important factors that may determine treatment response in patients with bipolar disorders (BD). Many factors have been described to be associated with treatment adherence in BD. Temperament that can influence the course of BD will have an impact on treatment adherence. The aim of this study is to investigate temperament effect on treatment adherence in euthymic patients with BD-I. Methods: Eighty patients with BD-I participated in the study. A psychiatrist used the Structured Clinical Interview for DSM-IV Axis-I Disorders to determine the diagnosis and co-morbidities. Hamilton Depression and Young Mania Rating Scale were used to detect the remission. We used the Temperament Evaluation of Memphis, Pisa, Paris, San Diego Autoquestionnaire and the 4-item Morisky Medication Adherence Scale to evaluate temperament and treatment adherence, respectively. The study group was divided into two groups as "treatment adherent" and "treatment non-adherent". Results: The cyclothymic and anxious temperament scores of the treatment non-adherent patients with BD-I were significantly higher than those of the treatment adherent group (p < 0.001, p = 0.006, respectively). Multiple linear regression analysis determined that cyclothymic temperament predicted treatment non-adherence (p = 0.009). Conclusion: It should be kept in mind that BD-I patients with cyclothymic temperament may be treatment non-adherent and future studies should explore whether temperament characteristics deteriorate BD-I course by disrupting treatment adherence.
  • Öğe
    Validity and Reliability of Turkish Translation of Neuropathic Pain Impact on Quality-of-Life (NePIQoL) Questionnaire
    (Wiley-Blackwell, 2016) Acar, Betul; Turkel, Yakup; Kocak, Orhan M.; Erdemoglu, A. Kemal
    ObjectivesThe aim of this study was to adapt the Neuropathic Pain Impact on Quality-of-Life Questionnaire (NePIQoL) into Turkish and to test its validity and reliability in neuropathic pain patients. MethodsWe enrolled 200 chronic pain patients who admitted to the Neurology Department of Kirikkale University, Faculty of Medicine, in our study. Patients were diagnosed with neuropathic or nociceptive pain based on medical history, physical examination, electromyography and nerve conduction studies, laboratory examinations, and imaging techniques. Discriminant analysis was used to diagnose the neuropathic pain regarding sensitivity and specificity. The original version of the NePIQoL was translated into Turkish by standard procedures. ResultsTotal NePIQoL scores were statistically different between neuropathic and nociceptive pain patients in both the first and second NePIQoL applications (P<0.001). Cronbach's alpha coefficient of total 12 items of the first and second applications was 0.95. These results suggest a high validity level for the Turkish version of the NePIQoL. ConclusionsThe Turkish version of NePIQoL appears to be reliable and valid for neuropathic pain impact on quality of life in patients with neuropathic pain.
  • Öğe
    Effects of comorbid anxiety disorders on the course of bipolar disorder-I
    (Taylor & Francis Ltd, 2015) Buturak, Sadiye Visal; Kocak, Orhan Murat
    Background and aims: Although comorbid anxiety disorders (AD) are quite frequent in bipolar disorders (BD), data on how this comorbidity affects BD are limited. In the present study, we aimed to investigate the frequency of comorbid AD in Turkish patients with bipolar disorder-I (BD-I) and the effects of comorbid AD on the course of BD-I. Methods: 114 patients with BD-I were included in the study. All patients were diagnosed by a psychiatrist. The patients were divided into two groups as BD-I patients with lifetime comorbid AD (BDI-CAD) or those without comorbid AD (BDI). Results: 37 (32.46%) patients had one or more comorbid lifetime AD. The numbers of admissions to the outpatient clinic within calendar year 2013 (P = 0.014), the number of lifetime mood episodes (P = 0.019) and the duration of BD (P = 0.007) were higher in the BDI-CAD group compared with the BDI group. There was a strong relationship between the duration of the disorder and the number of episodes (r = 0.583, P < 0.001). Partial correlation analyses showed that the number of admission to the outpatient clinic correlated significantly with the frequency of episodes (P = 0.007, r = 0.282). Conclusion : We found that the patients with BDI-CAD use the healthcare system more frequently than the BDI patients. This suggests that AD comorbidity may have a negative influence on the course of BD-I and it is a factor that should be considered in the clinical follow-up.
  • Öğe
    Can compulsions be associated with problems in forming an internal model of the completed state of an action?
    (2017) Koçak, Orhan Murat; Kırkıcı, Bilal; Dağlı, Mustafa; Kafadar, Tugay; Özpolata, Ayşe Gül Yılmaz
    Amaç: Bu çalışmanın amacı, Obsesif Kompulsif Bozukluğun (OKB) bir hareketi tamamlama durumu için oluşturulan ileriye dönük bir modeli, uygun şekilde oluşturamayacağına yönelik bozuk işlevli bir hareket sistemi ile bağlantılı olduğu hipotezin test edilmesidir.Gereç veYöntemler: Çalışmada üç bilgisayar deneyi sunulmaktadır. Her üç deneyde de, farkı durumları ifade eden kelimelere reaksiyon zamanları, ana bağımlı değişkeni oluşturmuştur. Deneyler, OKB'li hastaların mükemmeliyetçilik yönü olan cümlelerde ve/veya tamamlanmış hareketlerde zorluklar yaşadıkları ve bu nedenle bağlantılı bir uyarıya daha uzun reaksiyon zamanları gösterdikleri hipotezini test etmek için yürütüldü. OKB'li toplam 40 katılımcı (Deney 1 de 16, Deney 2 ve 3 de 24'er kişi) ve yaş, cinsiyet, ve eğitimleri uyumlu 40 non-obsesif kontrol katılımcı çalışmaya dahil edildi. Deney 1, katılımcının kelime/kelime dışı bir duruma karar verme konusunda talimat verildiği ve eş zamanlı olarak ekrandaki gösterilen uyarı tarafından kodlanmış temporal referansta, kelimelere ait bir karar verme görevi idi. Deney 2'de katılımcılar bir dizi hareketi yerine getirmek ve kendilerinin yaptıkları hareketlerin bütünlüğünün uygun veya uygunsuz olarak tanımlanıp yansıtıldığı uyarı cümlelerini oranlamak zorunda idi. Deney 3'de katılımcılar, Deney 2'de daha önce yaptıkları görevle bağlantılı olarak, uyarı cümlelerinin doğruluk değerlerini oranladılar.Bulgular: Bulgular bir bütün olarak, OKB'li hastaların kontrol grubu ile karşılaştırıldığında, mükemmeliyetçilik yönü olan hareketlerle ilgili cümlelere daha uzun reaksiyon zamanları gösterdiklerini ortaya koymuştur.Sonuçlar: Elde edilen bulgular, OKB'da ileri beslemeli hareket denetiminin problemli olduğu varsayımını destekleyici olarak ele alınabilir