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The effect of different irrigation solutions and activation techniques on the expression of growth factors from dentine of extracted premolar teeth
(Wiley, 2021) Hançerlioğullari, Dilek; Erdemir, Ali; Kısa, Üçler
Aim To evaluate in a laboratory study, the effect of different canal irrigant solutions and activation techniques on transforming growth factor (TGF-beta 1), insulin growth factor-1 (IGF-1), bone morphogenetic protein-7 (BMP-7) and vascular endothelial growth factor-A (VEGF-A) release levels from the dentine of extracted premolar teeth. Methodology Seventy premolar teeth with single root and canal were used. The lengths of the root segments were standardized to 12 mm, and the root canals were prepared up to size 100 with hand files. All surfaces of the teeth were covered with nail polish except the inner root canal surface. The root canals were irrigated with 1.5% NaOCl. Ten teeth were allocated to the control group. The remaining sixty teeth were divided into 2 main groups according to the chelating agent used (17% EDTA, 10% Citric acid; CA) and 3 subgroups (n = 10) according to irrigation activation technique (conventional syringe irrigation (CSI), passive ultrasonic irrigation (PUI) and Er:YAG laser activation). After the activation procedure, the root segments were placed into eppendorf tubes containing 1 mL of phosphate-buffered saline solution and kept at 37celcius. TGF-beta 1, IGF-1, BMP-7 and VEGF-A release levels from dentine were measured using the enzyme-linked immunosorbent assay (ELISA) method at 24 h and at day 7. The volume of root canals was calculated using cone-beam computed tomography. The growth factor levels were calculated in ng/mL except VEGF-A (pg/ml). Normality analysis of the data was evaluated with the Kolmogorov-Smirnov test. Statistical analysis was performed using the Mann-Whitney-U and Wilcoxon tests. Results Regardless of the activation type and sampling time, EDTA caused significantly more IGF release than did CA, whereas EDTA and CA were equally effective for the release of the other growth factors. For either EDTA or CA, the lowest and highest growth factor release levels were observed in the CSI and Er:YAG laser groups, respectively (p < .05). All of the growth factors were released significantly more at 24 h than on day 7 (p < .05). Conclusions Irrigation activation techniques with EDTA or CA increased the release levels of all growth factors from the dentine of canal walls in extracted premolar teeth.
The Determination Of The Effect Of Various Types Of Sodium Perborate On Bond Strength Of Composite Using Microtensile Test Technique
(Istanbul Univ Press, Istanbul Univ Rectorate, 2005) Ari, Hale; Eldeniz, Ayce U.; Erdemir, Ali
The aim of this in-vitro study was to evaluate bond strength of composite resin after intracoronal bleaching treatment with different types of sodium perborate (SP) mixed with water or hydrogen peroxide using a microtensile bond strength test. Eighty human upper central incisor teeth extracted for periodontal reasons were used. Following obturation, the teeth were randomly divided into eight groups including 10 teeth each. Bleaching agents were then placed in the pulp chamber as follows; Group 1: SP monohydrate (MH) + water, Group 2: SP trihydrate (TRH) + water, Group 3: SP tetrahydrate (TH) + water, Group 4: SP-MH + hydrogen peroxide (HP), Group 5: SP-TRH + HP, Group 6: SP-TH + HP, Group 7: water, Group 8: HP. Access cavities were then sealed with Cavil. The bleaching materials were then replaced at 3 day intervals. After 7 day bleach the crowns were cut vertically from mesial to distal and the labial pulp chamber dentine was prepared for bonding
Quality of information in #brokenfileremoval Reels videos on Instagram: a cross-sectional study
(Springer Heidelberg, 2023) Hancerlioğulları, Dilek; Ceylanoğlu, Eray
Aim Instagram is a popular social media platform for sharing videos and photos that is widely used by individuals worldwide. The objective of this study was to assess the information quality of Reels videos on Instagram with respect to broken files, a complication in endodontic treatment.Subject and methods Reels videos were searched on May 16 between 19:00 and 23:00 using English hashtags (#brokenfile, #brokenfileremoval, #brokeninstrument, #brokeninstrumentremoval). The videos related to the subject were examined based on their characteristics and uploaders. The videos were evaluated by Global Quality Scale (GQS) scores, modified DISCERN, and JAMA criteria. Descriptive statistics were obtained, and the data were analyzed with the Kruskal-Wallis and Spearman rho tests.Results Of the 205 downloaded Reels videos, 54 met the criteria for analysis. Most posts were posted by specialists (79.62%, n = 43), hospitals/universities/clinics (9.25%, n = 5), health-related businesses (5.55%, n = 3), and others (5.55%, n = 3). The GQS (1.50 +/- 0.66), modified DISCERN score (1.57 +/- 0.68), and JAMA criteria (1.85 +/- 0.41) of Instagram video posts about #brokenfileremoval were found to be very low. A strong positive correlation was found between the number of followers and viewing rates (p < 0.001).Conclusion The Reels videos related to #brokenfile #brokenfileremoval, #brokeninstrument, and #brokeninstrumentremoval were limited in number and of low quality. Therefore, specialists should upload more comprehensive videos to effectively utilize this platform.
Potential Crown Discoloration Induced by the Combination of Various Intracanal Medicaments and Scaffolds Applied in Regenerative Endodontic Therapy
(Wolters Kluwer Medknow Publications, 2024) Altun, N. B.; Türkyılmaz, Ali
Background:Regenerative endodontics involves the use of various root canal medicaments and scaffolds, which may cause crown discoloration. Aim:This study aimed to investigate the combined crown discoloration of scaffolds [platelet-rich fibrin (PRF) and blood clot] applied after administration of different medicaments [modified triple antibiotic paste including doxycycline (mTAPd), modified double antibiotic paste (mDAP), calcium hydroxide (CH), and propolis]. Methods:In total, 100 human mandibular premolar teeth were selected and prepared. The teeth were apically resected to simulate immature teeth. The positive and negative control groups (n = 10) consisted solely of blood-only and serum-only samples. The remaining 80 teeth were used for the experimental groups with four different medicaments. Three weeks later, either blood or PRF was applied as a scaffold after removing the medicaments (n = 10). Color changes were assessed before medication placement and at the end of the first, second, and third weeks, as well as on days 0, 1, 30, 60, and 90 after scaffold application. Analysis was carried out using repeated measures of variance, Friedman, one-way ANOVA, Kruskal-Wallis, the dependent paired t-test, and Wilcoxon test. Results:Statistical significance was determined at P = 0.05. All groups including blood and the group including propolis and PRF combination, resulted in a significant increase in discoloration (P < 0.05) and discoloration exceeding clinically acceptable thresholds. Conclusions:CH and the modified versions of TAP (mTAPd) and DAP (mDAP) demonstrated an acceptable level of discoloration when used with a combination of PRF at day 90.
Postobturation Pain of three Novel Calcium Silicate-based sealers with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis: prospective clinical trial
(Bmc, 2024) Türkyılmaz, Ali; Barış, Sevda Dürüst; Hançerlıoğulları, Dilek; Erdemir, Ali
Background Bioceramic-based root canal sealers are increasingly important in root canal treatment because of their biocompatible properties. This study aimed to evaluate postobturation pain incidence and intensity after root canal obturation with NeoSealer Flo, MTA-Bioseal, and GuttaFlow bioseal calcium silicate-based sealers and AH Plus epoxy resin-based sealer in patients with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis. Methods A total of 120 participants with single-rooted teeth were included and randomly divided into four groups according to the root canal sealer used (n = 30). The patients were subsequently categorised based on the pulp vitality (vital or nonvital) in each group (n = 15) and all teeth were obturated in a single-visit. The postobturation pain scores were recorded on a visual analogue scale (VAS) at 6 h, 24 h, 48 h, 72 h, 7 d and 30 d. Moreover, analgesic intake was also noted at 24 h and 48 h. The Mann-Whitney U test, Kruskal-Wallis H test, Friedman test, and Spearman's correlation test were used, and a p value < 0.05 was considered significant. Results VAS scores were highest for the 6 h > 24 h > 48 h approximate to 72 h approximate to 7 d approximate to 30 d time intervals for both pulp status in each root canal sealer. A significant decrease in the VAS score was observed for all sealers from 6 h to 48 h (p 0.05). Nonvital cases had lower VAS scores at all time intervals. Analgesic intake was greater in the first 24 h (p < 0.05) in vital cases (p < 0.05) and also in females than males. Conclusion The level of pain experienced after obturation was similar in patients with different pulp status for all the root canal sealers. Analgesic intake was greater in vital cases and females within 24 h.
Several Shaping Characteristics of OneCurve Continuously Rotating System versus Three Different Kinematic Systems: ProTaper Universal, Twisted File Adaptive and WaveOne Gold
(Galenos Publ House, 2022) Türkyılmaz, Ali; Arıkan, Volkan
Objective: This study aimed to compare the curvature change, preparation time, resin removal amount and working length reduction properties of the OneCurve (0.25/0.06), ProTaper Universal F2 (0.25/0.06), Twisted File Adaptive SM2 (0.25/0.06) and WaveOne Gold Primary (0.25/0.07) using simulated root canal models. Materials and Methods: A total of 67 plastic models were used. Three models were used to verify the initial curvature angle, the weight of the unprepared resin block and the initial root canal length. The remaining 64 models were divided into four groups of 16 samples. After preparation, the changes in parameters were measured again. Statistical analysis was done with SPSS 22.0 using one-way ANOVA and post hoc Tukey's tests and Kruskal-Wallis with Bonferroni corrections. Pearson and Spearmen correlation coefficients were also used. A p-value <0.05 was significant. Results: Significant differences were observed between OneCurve, ProTaper Universal F2, Twisted File Adaptive SM2 and WaveOne Gold Primary file systems in terms of resin removal amount, root canal curvature change and preparation time (p<0.05). The correlations were statistically significant (p<0.05). Conclusions: Twisted File Adaptive SM2 performed significantly less resin removal and curvature change. Furthermore, the Twisted File Adaptive and WaveOne Gold Primary instruments required less preparation time compared with OneCurve and ProTaper Universal F2.
A Radiographic Assessment of the Prevalence of Pulp Stones in Patients Who Presented to Ataturk University Faculty of Dentistry Department of Oral Diagnosis and Radiology
(Istanbul Univ Press, Istanbul Univ Rectorate, 2014) İlday, Nurcan Özakar; Miloğlu, Özkan; Demirtaş, Ömer; Yıldırım, Eren; Seven, Nilgün; Sağsöz, Ömer
Purpose: The aims of this study were to determine the prevalence of pulp stones in a group of Turkish dental patients using panoramic radiographs and dental records, and to report any associations between the presence of pulp stones and age, sex, tooth type, dental status, dental anomalies or systemic diseases. Materials and Methods: Data were collected through radiographic examination of panoramic radiographs and dental records of 4798 dental patients. The presence of pulp stones was recorded. Chi-square analyses were used to compare the frequency of occurrence o75f pulp stones between the parameters. Results: Pulp stones were identified in 168 (3.5%) patients examined. Six hundred twenty (0.5%) of 122405 teeth had pulp stones. Gender, tooth type and dental status were correlated with the presence of pulp stones (p< 0.05). No significant association existed between pulp stones and age, dental anomalies or systemic diseases (p>0.05). Conclusion: Under the limitations of the present study, pulp stones were detected in 3.5% of 4798 patients and 0.5% of 122405 teeth examined using panoramic radiographs. Molars contained significantly more pulp stones than other tooth types. Carious and/or restored first and second molars exhibited a significantly higher prevalence of pulp stones than intact molars. Further studies are needed to clarify the higher pulp stone prevalence in molars and the possible association between the occurrence of pulp stones and pulpal irritations.
Effect of Different Irrigation Activation and Condensation Techniques on the Marginal Adaptation of White MTA
(Galenos Publ House, 2023) Türkyılmaz, Ali; Özbay, Yağız; Dinçer, Gözde Akbal; Erdemir, Ali
Objective: To evaluate the effect of different irrigation activation and condensation techniques on the marginal adaptation ability of white ProRoot mineral trioxide aggregate (MTA). Materials and Methods: Eighty single-rooted human teeth were prepared to a ProTaper Universal F4 file. Initially, the roots were randomly divided into four groups as follows: conventional syringe irrigation in group 1, sonic activation (EDDY) in group 2, passive ultrasonic irrigation in group 3, and Er:YAG laser in group 4. Then, ProRoot MTA was set with hand condensation or ultrasonic condensation techniques, and the adaptation ability of MTA was investigated using SEM. Results: EDDY activation had the lowest gap scores (p<0.001). No statistical differences were observed between the regions (p>0.05), and condensation techniques (p>0.05). Conclusion: The marginal adaptation of ProRoot MTA to root dentine increased with EDDY activation, and the marginal adaptation ability of the material was not affected by the condensation technique.
Effect Of Sodium Thiosulfate On Bond Strength An Epoxy Resinbased Sealer To Sodium Hypochloride- And Citric Acid- Treated Dentin
(2020) Yıldız, Ezgi Doğanay; Arslan, Hakan; Özdemir, Mine; Uzun, İsmail; Karataş, Ertuğrul; Özdoğan, Dt Alper; Yapar, Merve İşcan
Aim: The aim of this study was to evaluate the effect of sodium thiosulfate on the bond strength of an epoxy resin-based sealer to NaOCl- and citric acid-treated dentin. Materials and Methods: Fifteen maxillary central incisors were selected. Three discs (1.0 ± 0.1 mm thick) were cut from the middle third of the roots. Two holes were prepared in the root dentin. All of the specimens were immersed in 5.25% NaOCl for 30 minutes, immersed in 10% citric acid for 1 minute and 5.25% NaOCl for 1 minute. The specimens were randomly distributed into 3 groups: group 1: control group (no irrigation); group 2: distilled water group (immersed in distilled water for 10 minutes); and group 3: sodium thiosulfate group (immersed in 5% sodium thiosulfate for 10 minutes). The holes were filled with an epoxy resin-based sealer. A push-out test was performed on each hole. The data were analyzed statistically. Results: The bond strength of the specimens irrigated with sodium thiosulfate was higher than that of the control group (P < 0.05). However, there was no significant difference between the control and the distilled water groups (P > 0.05). Conclusions: Within the limitations of the present study, it can be concluded that 5% sodium thiosulfate for 10 min increased the bond strength of the sealer to NaOCl- and citric acid-treated dentin.
The effect of various types of sodium perborate bleaching agents on shear bond strength of composite resin
(2013) Belll, Sema; Aydınbelge, Hale Arı; Erdemlr, Ali; Eldeniz, Ayşe Ünverdı
The effect of various types of sodium perborate bleaching agents on shear bond strength of composite resin Aim: The purpose of this study was to evaluate various types of sodium perborates mixtures effect on shear bond strength of composite resin. Material and Methods: Eighty extracted central teeth were used in this study. The crowns were splitted mesiodistally from the incisal edges to cervicals. Buccal parts of the teeth were mounted in a 4cm pipe with the use of cold acylic resin with their buccal surfaces downward. Dentin surfaces were polished and divided into main 2 groups according to the mixing solutions (n=40) (water or 30% hydrogen peroxide) and into four subgroups according to the sodium perborate type used (monohydrate, trihydrate, tetrahydrate and only the solution as control) (n=10). The dentin surfaces of the groups were treated with fresh bleaching pastes and stored in an incubator. Composites were placed onto the dentin surfaces by packing the material into cylindrical shaped matrix. Shear bond strength of each sample was measured and calculated in MPa. Results: Mixing with hydrogen peroxide decreased bond strength values significantly (p<0.05). Higher bond strength values were obtained in tetrahydrate mixed with water group. Conclusions: For the success of composite restorative treatment that will be applied to non-vital colored teeth, mixing bleaching agents with water may be preferential.
Duration of ultrasonic activation causing secondary fractures during the removal of the separated instruments with different tapers
(SPRINGER HEIDELBERG, 2020) Arslan, Hakan; Yildiz, Ezgi Doganay; Tas, Gizem; Akbiyik, Nuray; Topcuoglu, Huseyin Sinan
Objectives The aim of the present study was to determine the effect of taper (.08, .06, and .04) of separated K3XF instruments on duration taken for the secondary fracture formation during ultrasonic activation. Materials and methods Ten 25/.08 K3XF (SybronEndo, Orange, CA, USA), ten 25/.06 K3XF, and ten 25/.04 K3XF instruments were used for the study. The apical 5 mm of the instruments was cut to simulate the fragments in root canals. Fragments of the instruments were sandwiched between two straight dentin blocks. An ultrasonic tip was used to cause a secondary fracture of the fragment. The time needed for the secondary fracture was recorded for each instrument. The data were statistically analyzed using the Kruskal-Wallis H test (alpha = 0.05). Results Secondary fractures occurred in all instruments. In the .08 taper group, secondary fractures took longer than in the case of the .06 and the .04 taper groups (P < 0.05). There were no significant differences between the .06 and the .04 taper groups in terms of the time required for the occurrence of a secondary fracture (P > 0.05). Conclusions In the .08 taper group, secondary fracture took longer time than in the case of the .06 and the .04 taper groups due to its larger cross-sectional area involved.
Effect of different laser-assisted irrigation activation techniques on apical debris extrusion
(TAYLOR & FRANCIS LTD, 2020) Doganay Yildiz, Ezgi; Dincer, Buket; Fidan, Mehmet Eren
Objective: The aim of this study was to compare apical debris extrusion when neodymium-doped yttrium aluminium garnet (Nd:YAG) lasers, erbium-doped yttrium aluminium garnet (Er:YAG) or photon-induced photoacoustic streaming (PIPS) are used for irrigation activation. Materials and methods: A total of 60 extracted human mandibular premolar teeth have similar dimensions were included and the samples were split into four groups according to the irrigation technique (n = 15): conventional needle irrigation, PIPS, Er:YAG and Nd:YAG. ProTaper Universal system up to F4 was used for root canal instrumentation. Bidistilled water was used as an irrigation solution during instrumentation and irrigation activation. Apically extruded debris was collected into preweighed Eppendorf tubes during instrumentation and irrigation activation procedures. The tubes were then kept in an incubator at 70 degrees C for 5 days. The initial weight of the tube was subtracted from the final weight and the result was recorded as the weight of dry extruded debris. The data were evaluated statistically using a one-way ANOVA test followed by least significant difference post hoc test (p < .05). Results: Conventional needle irrigation caused significantly less debris extrusion than laser-assisted irrigation activation groups (p < .05). Laser-assisted irrigation activation groups caused statistically similar debris extrusion (p > .05). Conclusion: Laser-assisted irrigation activation techniques caused more debris extrusion when compared to conventional needle irrigation.
Effect of dentin and fiber post surface treatments with fumaric acid on the bonding ability of fiber posts
(WILEY, 2020) Saricam, Esma; Arslan, Merve
This study investigated the effects of fumaric acid on push-out bond strength when applied to dentin surfaces and fiber posts. The root canals of 60 mandibular premolar teeth were instrumented and obturated. After removing two thirds of filling material, teeth were prepared according to six randomized groups (n= 10/group) defined by two fiber post surface treatments (0.7% fumaric acid or 9% hydrofluoric acid) and three dentin conditioning treatments [control (no conditioning); 17% ethylenediamine tetraacetic acid (EDTA); or 0.7% fumaric acid]. After fiber post-cementation, three 1-mm thick discs were obtained from each tooth by transverse sectioning, and each disc underwent push-out bond strength testing. Data were analyzed with a one-way analyses of variance (anova) andttests;p < .05 was considered statistically significant. Failure modes were determined by stereomicroscopy, and the surface characteristics of dentin and fiber posts were observed by scanning electron microscopy. Push-out bond strength was greater for the group in which the post surface treated with hydrofluoric acid and the dentin surface treated with fumaric acid than the nontreated dentin and hydrofluoric acid-treated post group (p < .05). There were no significant differences between other comparison pairs (p > .05). A combination of fumaric acid dentin conditioning and hydrofluoric acid fiber post treatment strengthened the bonding ability of fiber posts.
Comparison of Neurokinin A, Substance P, Interleukin 8, and Matrix Metalloproteinase-8 Changes in Pulp tissue and Gingival Crevicular Fluid Samples of Healthy and Symptomatic Irreversible Pulpitis Teeth
(ELSEVIER SCIENCE INC, 2020) Dincer, Gozde Akbal; Erdemir, Ali; Kisa, Ulcer
Introdution: The aim of this study was to compare levels of neurokinin A (NKA), substance P (SP), interleukin (IL)-8, and matrix metalloproteinase-8 (MMP-8) in pulp tissue and gingival crevicular fluid (GCF) samples of healthy and symptomatic irreversible pulpitis teeth. Methods: Forty patients diagnosed with healthy and symptomatic irreversible pulpitis teeth were included in this study. NKA, SP, IL-8, and MMP-8 levels were measured using the enzyme-linked immunosorbent assay test after pulp and GCF samples were obtained from healthy (n = 20) and symptomatic irreversible pulpitis teeth (n = 20). GCF sampling of 40 teeth was repeated 1 week later. Routine root canal treatment procedures of the teeth were performed, and the treatment process was completed. As a control group, GCF samples were taken from the contralateral teeth in both groups. Statistical analysis was performed using dependent and independent t tests, analysis of variance, Kruskal-Wallis, Mann-Whitney U tests, and Pearson correlation analysis. Results: Comparing the groups, all mediator levels were significantly higher in the pulp samples in the pulpitis group compared with the healthy group (NKA: P < .001, SP: P = .005, IL-8: P < .001, and MMP-8: P < .001). Likewise, in the pulpitis group, all mediator levels were significantly higher in the first GCF samples compared with the healthy group (NKA: P = .01, SP: P < .001, IL-8: P = .001, and MMP-8: P < .001). Conclusions: It was observed that NKA, SP, IL-8, and MMP-8 increased significantly in pulp tissue and GCF specimens of symptomatic irreversible pulpitis teeth compared with pulp tissue and GCF specimens of healthy teeth. Second, it was determined that NKA, SP, IL-8, and MMP-8 levels decreased significantly in GCF samples in teeth diagnosed with symptomatic irreversible pulpitis 1 week after the removal of inflamed pulp. Finally, SP, IL-8, and MMP-8 levels were found to be higher in pulp tissue samples of the patients with symptomatic irreversible pulpitis with higher pain scores than those with low pain scores.
The effect of taper and apical preparation size on fracture resistance of roots
(WILEY, 2020) Yildiz, Ezgi Doganay; Fidan, Mehmet Eren; Sakarya, Rustu Ersoy; Dincer, Buket
This study investigated the effect of taper and apical preparation size on the fracture resistance of roots. 84 mandibular incisor teeth were selected. Groups (n = 12): uninstrumented (control group), 25/0.04, 25/0.06, 25/0.08, 30/0.04, 30/0.06 and 30/0.08. K3XF files (Kerr Endodontics, Orange, CA) were used for canal preparation. Fracture resistance was tested using a Universal test machine. For statistical analysis, the level of significance was P <= 0.05, and one-way anova and post hoc LSD tests were used. The control group showed the highest fracture resistance (P < 0.05). No significant difference was found between 25/0.04 and 25/0.06; 25/0.06 and 25/0.08; 30/0.04 and 30/0.06; 30/0.06 and 30/0.08; 25/0.04 and 30/0.04; 25/0.06 and 30/0.06; and 25/0.08 and 30/0.08 (P > 0.05). Significant differences were found between 25/0.04 and 25/0.08; 30/0.04 and 30/0.08; and 25/0.08 and 30/0.04 (P < 0.05). In conclusion, the clinical selection of larger tapers can cause a higher risk of fracture.
Endodontic management of a patient with dystrophic epidermolysis bullosa: A case report
(WILEY, 2020) Türkyılmaz, Ali; Bulut, Ali Can; Hancerlioğulları, Dilek
Epidermolysis bullosa is a congenital genetic disease that causes blistering and erosion of the skin and mucosa. The main known forms include simple, junction, dystrophic and mixed subtypes. This case report presents the endodontic management and 1-year follow-up of a 27-year-old female patient with epidermolysis bullosa who was referred to the Faculty of Dentistry, Kirikkale University, Turkey. An extraoral examination showed that the patient had multiple scars and blisters. The intraoral examination revealed ankyloglossia, microstomia, shallow buccal and vestibular sulci, enamel hypoplasia, gingival inflammation, mouth ulcers, symptomatic and asymptomatic deep caries, a tooth with an apical lesion and a tooth with pulpitis. The dental treatment was divided into four stages: (i) oral hygiene motivation and elimination of gingival bleeding, (ii) restorative and/or endodontic procedures, (iii) extractions and prosthetic treatments and (iv) recall appointments. A 1-year follow-up radiographic examination of the periapical status of the root canal treatments was clear.
The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial
(Springer London Ltd, 2019) Yildiz, Ezgi Doganay; Arslan, Hakan; Koseoglu, Serhat; Arabaci, Taner; Yildiz, Dursun Anil; Savran, Levent
To investigate the effect of photobiomodulation (PBM) and placebo on total amount of substance P in gingival crevicular fluid (GCF) pre- and postoperatively. Twenty-six patients having tooth with symptomatic apical periodontitis were enrolled in this study. GCF was collected preoperatively. The patients were assigned into two groups (n=13), as follows: placebo and PBM. Sampling was repeated 7days after root canal treatment. Two independent samples T test was used for analyzing of the differences between preoperative and postoperative substance P levels in GCF (p=.05). The Pearson correlation analysis was used for determination of correlation among substance P levels and other variables. For placebo group, there is no significant difference between preoperative and postoperative total amounts of substance P level (p=0.553). For PBM group, postoperative total amount of substance P level was significantly higher than those of preoperative level (p=0.005). Within the limitation of the present study, PBM has immunomodulation effect linked to the modulation of the total amount of substance P in the gingival crevicular fluid. Thai Clinical Trials Registry: TCTR20161228002
Acupuncture reduces the postoperative pain in teeth with symptomatic apical periodontitis: a preliminary randomized placebo-controlled prospective clinical trial
(Quintessence Publishing Co Inc, 2019) Arslan, Hakan; Ahmed, Hany Mohamed Aly; Yildiz, Ezgi Doganay; Gundogdu, Eyup Candas; Seckin, Fatih; Arslan, Sumeyye
Objective: Endodontic treatment generally results in a wide range of postoperative pain intensity. The aim of this study was to investigate the effect of preoperative acupuncture on postoperative pain in molar teeth with symptomatic apical periodontitis. Method and Materials: Thirty patients having symptomatic apical periodontitis with a preoperative and percussion pain of visual analog scale (VAS) more than 60 were included in this study. The patients were randomly distributed into two groups; G1, real acupuncture; and G2, placebo (mock acupuncture). After 15 minutes of application, root canal treatment was performed. A logistic regression analysis was used to determine the variable(s) (group, age, gender, tooth number, preoperative pain, preoperative percussion pain, and radiographic status) that controls the postoperative pain significantly. Chisquare, Mann Whitney U, and independent t tests were per-formed to analyze the data, and the level of significance was set at .05 (P = .05). Results: A regression analysis demonstrated that the group variable had the most significant effect on postoperative pain at day 1 (P = .003). Results showed that acupuncture reduced the preoperative and percussion pain levels significantly more than placebo group at all day intervals (P < .05). For postoperative pain at the 7-day follow-up, the pain ranged from "mild" to "no pain" in G1, compared with "moderate" to "minimal" in G2. Only one patient required postoperative analgesics in the acupuncture group compared to eight patients for placebo. Conclusions: Preoperative acupuncture can be beneficial in reducing postoperative pain in teeth with symptomatic apical periodontitis.
Regenerative Endodontic Procedures in Necrotic Mature Teeth with Periapical Radiolucencies: A Preliminary Randomized Clinical Study
(Elsevier Science Inc, 2019) Arslan, Hakan; Ahmed, Hany Mohamed Aly; Sahin, Yavuz; Yildiz, Ezgi Doganay; Gundogdu, Eyup Candas; Guven, Yahya; Khalilov, Ruslan
Introduction: This preliminary study compared clinical and radiographic outcomes of regenerative endodontic procedures (REPs) with that of conventional root canal treatment (CRCT) in necrotic mature teeth with periapical radiolucencies. Methods: Fifty-six mature necrotic teeth with large periapical radiolucencies were distributed into 2 groups: group 1, REPs and group 2, CRCT (n = 28/group). Clinical and radiographic follow-up assessments were undertaken up to 12 months. Statistical analysis was performed using the independent samples t test and the chi-square test, and the level of significance was set at P = .05. Results: With a follow-up rate of about 73.4% of the total patients for 12 months, favorable clinical and radiographic outcomes were found in 92.3% and 80% in REPs and CRCT groups, respectively, and the difference was not statistically significant (P > .05). Half of the teeth treated with REPs responded to the electric pulp test. Conclusions: Regenerative endodontic procedures have the potential to be used as a treatment option for mature teeth with large periapical radiolucencies.
Success of maintaining apical patency in teeth with periapical lesion: a randomized clinical study
(Quintessence Publishing Co Inc, 2019) Arslan, Hakan; Yildiz, Ezgi Doganay; Topcuoglu, Huseyin Sinan; Tepecik, Ebru; Ayaz, Nilay
Objective: The aim of this study was to evaluate the effect of maintaining apical patency on periapical healing and postoperative pain levels in teeth with necrotic pulp and apical periodontitis. Method and materials: Fifty mature teeth with periapical lesions were randomly distributed into two treatment groups: patency, and nonpatency (n = 25). Patients were followed up over a 12-month period using clinical and radiographic assessments.The data were statistically analyzed using independent-samples t test and chi-square tests at a 95% confidence level (P = .05). Results: Seventeen teeth in the patency group (85.0%) and 19 teeth in the nonpatency group (86.4%) were classified as being successfully treated (P = .900). Conclusions: Within the limitations of the present study, maintaining apical patency did not affect endodontic treatment outcomes.

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