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Öğe Is it feasible to adjust bisphosphonate dose according to bone mineral density value in postmenopausal breast cancer patients with bone metastases?(Churchill Livingstone, 2006) Delibasi, Tuncay; Akkuş, Nuri I.; Altundağ, Özden; Pınar, Tevfik; Altundağ, Kadri…Öğe Effects of combined female sex hormone replacement therapy on body fat percentage and distribution(Springer, 2006) Delibasi, Tuncay; Berker, Dilek; Aydın, Yusuf; Pinar, Tevfik; Özbek, MustafaThe effectiveness of hormone replacement therapy for patients with cardiovascular disease and for postmenopausal women with associated cardiovascular risks is currently under wide investigation. Among the cardiovascular risks are those related to body fat percentage and distribution. The present study undertook to investigate the effects of combined hormone replacement therapy on body fat percentage and distribution in postmenopausal women. Data for the present study were collected via retrospective analyses of 287 healthy postmenopausal women (146 as a study group, 141 as controls). Participants in the study group received 0.625 mg conjugated equine estrogen combined with 2.5 mg medroxyprogesterone acetate per day for 18 months. Body fat percentage and fat distribution were evaluated through the electrical impedance method and measurements of skinfold thickness, respectively. Two indices of centripetal fat distribution were defined: ratio of trunk-to-extremity skinfold thickness (T/E index), and ratio of upper-to-lower body skinfold thickness (U/L index). Investigators found that a daily dose of 0.625 mg of conjugated equine estrogen combined with 2.5 mg of medroxyprogesterone acetate taken for 18 months increased body fat percentage by decreasing lean body mass and by affecting upper-to-lower body fat distribution, without producing significant changes in overall weight. A slight decrease in the trunk-to-extremity body fat ratio was noted at 18 months of treatment, but this decrease did not reach statistical significance. Data related to the effects of hormone replacement therapy on body fat percentage and distribution in postmenopausal women are scarce. Additional research is needed to clarify the possible health benefits of hormone replacement therapy.Öğe Öğe Osteoporotic fractures as a public health problem(2008) Pınar, T.Osteoporosis is a disease that has a major effect on public health. The main problems to this burden are associated fragility fractures. The increased rates of morbidity and mortality consequent to these fractures have a massive impact on the health service, population and the economy. The prevention of fractures has therefore become a major public health priority. About 30% to 50% of women and 15% to 30% of men will experience a fracture during life time. Vertebral, hip, and wrist fractures are the most common sites. The incidence of vertebral and hip fractures increase exponentially with age, and they are more frequent in women than men in older age groups. Radiographical studies have indicated that only around 30% of vertebral fractures present clinically. There are differences in fracture prevalence between populations of different ethnicity and geographical locations. Season also has important impact on fracture incidence that hip fractures are more frequent in winter months. There has been a important increase in hip fracture incidence over the last 50 years, which may reach a plateau in Western populations. However, incidence is set to rise worldwide, as a result of increases in developing countries. Osteoporosis is underdiagnosed and undertreated in men and women in spite of modern techniques. Therefore, health care costs associated with osteoporosis are expected to rise dramatically. It is obvious that the public health burden of fractures cannot be solved with drug therapy. Interventions targeted to the community are needed that are safe, inexpensive, and affordable to all persons. Strategies adressing to reduce the burden of this major public health problem are urgently needed. Copyright © 2008 by Türk Tibbi Rehabilitasyon Kurumu Derneği.
