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Öğe An Adolescent Girl with an Extraordinary Crohn Disease(Springer, 2019) Gulerman, Fulya; Guven, Burcu; Celik, Cansu; Onaran, Zafer; Celikel, Banu AcarInflammatory bowel disease (IBD) is a comprehensive term used to describe diseases of the gastrointestinal tract resulting from chronic inflammatory processes. Patients with Crohn`s disease, a type of IBD, also may have extraintestinal findings. Joint symptoms and mucocutaneous involvement are the most common manifestations. Therefore, the presence of symptoms such as swollen, painful joints, aphthous stomatitis, erythema nodosum, uveitis, and pericarditis should not be avoided. A 15-year-old girl was admitted to our outpatient clinic with complaints of severe abdominal pain, nausea, vomiting and bleeding in one eye. The patient was diagnosed with acute pancreatitis and uveitis at the first evaluation, followed by bloody diarrhea and arthritis. In endoscopy, antrum, bulbus and second segment of duodenum were seen as hyperemic, nodular and edematous. In the colonoscopy, mucosa of the terminal ileum was granular and edematous. The cecum, the ascending colon, hepatic flexure, descending colon, sigmoid colon, and rectum mucosa were hyperemic, granular in appearance (cobblestone view) and lymphoid hyperplasic in appearance. The patient was diagnosed as multisystemic Crohn`s disease. The patient was followed up with prednisolone and mesalazine treatment. At the end of one-year follow-up, the symptoms of pancreatitis improved totally, but there were no response to the treatment for uveitis and arthritis, and patient developed pericarditis and bloody diarrhea continued occasionally. Infliximab, a biological agent (tumour necrotising factor alpha, TNFa blocker), was the second choice of treatment. The expected result could not be obtained and after 6 cure treatments medication was switched to adalimumab. After 6 cycles of treatment, the patient`s symptoms were completely regressed. In conclusion, it should be kept in mind that extraintestinal manifestations of IBD can occur in pediatric patients before the original signs of the disease occur. The management of these findings with new treatment modalities may result in more positive outcomes in the future.Öğe The correlation between aqueous and serum level of Apolipoprotein A1 and B and diabetic retinopathy(Wichtig Publ, 2015) Timur, I. E. E.; Ornek, K.; Caglayan, O.…Öğe A New Efficient Retina Stimulation Strategy for High Resolution Retina Implant Systems(Assoc Research Vision Ophthalmology Inc, 2014) Karagoz, Irfan; Sobaci, Gungor; Ozden, Mustafa…Öğe Adult-onset asthma and periocular xanthogranuloma(Wiley-Blackwell, 2011) Karabulut, A.; Onaran, Z.; Ayva, S.; Daphan, Unal B.; Kalpaklioglu, A.…Öğe Silicone intubation with the Ritleng method in children with congenital nasolacrimal duct obstruction(Mosby, Inc, 2006) Yazıcı, Bülent; Akarsu, Cengiz; Salkaya, MuhsinPurpose: To evaluate the technical properties and clinical efficacy of bicanalicular silicone intubation with the Ritleng method in children with congenital nasolacrimal duct obstruction. Methods. The Ritleng method was used for lacrimal intubation in 50 eyes of 42 consecutive patients (mean age, 37.3 months). All procedures were done by or under the supervision of one surgeon. The hollow Ritleng probe was inserted via the canaliculus into the inferior meatus. The polypropylene (Prolene) thread-guide, attached to the silicone tube, was advanced through the probe. Either the Prolene emerged from the nose spontaneously or it was retrieved using a hook without visualization. The tube ends were sutured to the nasal wall. Tube removal was planned for 3 months postoperatively. Resolution of signs and symptoms of lacrimal obstruction was assessed. The mean follow-up time was 18.1 months (range, 3 to 48 months). Results. The silicone tube was placed successfully in all eyes except 1 (98%). The mean procedure time was 26 minutes for each eye (range, 15 to 45 minutes). Both Prolene guides spontaneously emerged from the nose in only 8 eyes (16%). In the others, one or both Prolene guides were retrieved with a hook. Inadvertent tube dislodgement occurred in 21% of the eyes and required early tube removal. Success, ie, relief of signs and symptoms, was achieved in 86% of eyes. Conclusions:The Ritleng method of intubation for congenital nasolacrimal duct obstruction yields a high rate of success. Contrary to previous reports, our experience suggests that the surgeon must be prepared to retrieve the Prolene guide from the nose.Öğe Sildenafil itself can not be a possible cause of non-arteritic ischemic optic neuropathy(Wiley-Blackwell Publishing, Inc, 2004) Taner, P.; Basar, M. M.; Bilgili, M. Y.; Ergin, A.; Batislam, E.…
