Yazar "Isiklan, Nuran" için listeleme
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Aptamer-functionalized magnetic graphene oxide nanocarrier for targeted drug delivery of paclitaxel
Hussien, Nizamudin Awel; Isiklan, Nuran; Turk, Mustafa (Elsevier Science Sa, 2018)Targeted drug delivery has come out as a golden system owing to its capability to reduce side effects and increase efficacy. The application of graphene oxide (GO) based nanomaterials for targeted delivery has recently ... -
Controlled release of indomethacin from crosslinked alginate beads
Inal, Murat; Yigitoglu, Mustafa; Isiklan, Nuran (Walter De Gruyter Gmbh, 2008)Beads of the sodium alginate ( NaAlg) were prepared by dropping aqueous sodium alginate ( NaAlg) into glutaraldehyde ( GA) as a crosslinker and HCl as a catalyst mixture solution. Beads prepared were used to deliver a model ... -
Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles
Isiklan, Nuran; Altinisik, Zeynep (Elsevier Science Bv, 2019)Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted ... -
Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin - an antimicrobial drug
Guncum, Enes; Isiklan, Nuran; Anlas, Ceren; Unal, Nilgun; Bulut, Elif; Bakirel, Tulay (Taylor & Francis Ltd, 2018)In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles ... -
Development of thermo-responsive poly(vinyl alcohol)-g-poly(N-isopropylacrylamide) copolymeric membranes for separation of isopropyl alcohol/water mixtures via pervaporation
Kursun, Fatma; Isiklan, Nuran (Elsevier Science Inc, 2016)This study aims to develop thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) grafted poly(vinyl alcohol) (PVA-g-PNIPAAm) copolymer membranes for separation of isopropyl alcohol (IPA)/water mixtures via pervaporation. ... -
Development of thermo/pH-responsive chitosan coated pectin-graft-poly(N, N-diethyl acrylamide) microcarriers
Isiklan, Nuran; Tokmak, Seyma (Elsevier Sci Ltd, 2019)Pectin based micro/nanocarriers display promising properties for biomedical applications. In this study, thermo/pH-responsive chitosan coated pectin-graft-poly(N,N-diethyl acrylamide) (Pec-g-PDEAAm/CS) microcarriers ... -
Graft copolymerization of itaconic acid onto sodium alginate using benzoyl peroxide
Isiklan, Nuran; Kursun, Fatma; Inal, Murat (Elsevier Sci Ltd, 2010)Graft copolymers of sodium alginate (NaAlg) with itaconic acid (IA) were prepared in aqueous solution using benzoyl peroxide (BPO) as the initiator. Grafted copolymers (NaAlg-g-PIA) were characterized by Fourier transform ... -
Graft Copolymerization of Itaconic Acid onto Sodium Alginate Using Ceric Ammonium Nitrate as Initiator
Isiklan, Nuran; Kursun, Fatma; Inal, Murat (John Wiley & Sons Inc, 2009)Graft copolymers of sodium alginate (NaAlg) with itaconic acid (IA) were prepared in aqueous solution using ceric ammonium nitrate (CAN) as the redox initiator under N(2) atmosphere. The carboxylic acid groups of IA were ... -
ICG-Conjugated magnetic graphene oxide for dual photothermal and photodynamic therapy
Ocsoy, Ismail; Isiklan, Nuran; Cansiz, Sena; Ozdemir, Nalan; Tan, Weihong (Royal Soc Chemistry, 2016)Aptamer-functionalized magnetic graphene oxide conjugates loaded with indocyanine green (ICG) dye, or Apt@ICG@mGO, have been successfully developed for dual-targeted photothermal and photodynamic therapy. In general, a ... -
ICG-conjugated magnetic graphene xxide for dual photothermal and photodynamic therapy
Ocsoy, Ismail; Isiklan, Nuran; Cansiz, Sena; Ozdemir, Nalan; Tan, Weihong (Lippincott Williams & Wilkins, 2015)… -
In vitro release study of diltiazem hydrochloride from poly(vinyl pyrrolidone)/sodium alginate blend microspheres
Sanli, Oya; Bicer, Emine; Isiklan, Nuran (Wiley, 2008)Polymeric blend microspheres of poly(vinyl pyrrolidone) (PVP) with sodium alginate (NaAlg) were prepared by cross-linking with calcium ions and used to deliver a calcium channel blocker drug, diltiazem hydrochloride (DT). ... -
Microwave assisted synthesis and characterization of sodium alginate-graft-poly(N,N '-dimethylacrylamide)
Akin, Alper; Isiklan, Nuran (Elsevier Science Bv, 2016)Modification of sodium alginate (NaAlg) was carried out using N,N'-dimethylacrylamide (DMAAm) as a monomer and azobisizobutyronitrile (AIBN) as an initiator under microwave irradiation. The effect of reaction conditions ... -
Microwave based synthesis and spectral characterization of thermo-sensitive poly(N,N-diethylacrylamide) grafted pectin copolymer
Isiklan, Nuran; Tokmak, Seyma (Elsevier Science Bv, 2018)The functionalization of polysaccharides with synthetic polymers has attracted great attention owing to its application in many industrial fields. The aim of this work was to study the impact of pectin functionalization ... -
Microwave-assisted synthesis of alginate-g-polyvinylpyrrolidone copolymer and its application in controlled drug release
Yigitoglu, Mustafa; Aydin, Gulden; Isiklan, Nuran (Springer, 2014)The aim of this study is to synthesize graft copolymer (NaAlg-g-PVP) in microwave oven and prepare pH-responsive beads with high entrapment efficiency. For this purpose, PVP was grafted onto sodium alginate using microwave ... -
Microwave-induced synthesis of alginate-graft-poly(N-isopropylacrylamide) and drug release properties of dual pH- and temperature-responsive beads
Isiklan, Nuran; Kucukbalci, Gulcan (Elsevier Science Bv, 2012)The first decade of the 21st century saw an increasing interest in the development of devices and biomaterials for delivery of bioactive substances that can be controlled by external stimuli. This study deals with the ... -
Pectin-conjugated magnetic graphene oxide nanohybrid as a novel drug carrier for paclitaxel delivery
Hussien, Nizamudin Awel; Isiklan, Nuran; Turk, Mustafa (Taylor & Francis Ltd, 2018)Recent studies have shown that graphene oxide (GO) drug carrier functionalized with biocompatible natural polymers lead to higher loading efficacy and better stability with diminished cellular toxicity. Pectin (PEC) is one ... -
pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine
Isiklan, Nuran; Inal, Murat; Kursun, Fatma; Ercan, Gulden (Elsevier Sci Ltd, 2011)A series of pH responsive alginate-g-poly(itaconic acid) (NaAlg-g-PIA) microspheres were prepared as drug delivery matrices of nifedipine cross-linked by glutaraldehyde (GA) in the hydrochloric acid catalyst. Graft copolymers ... -
pH/temperature-responsive poly(dimethylaminoethyl methacrylate) grafted kappa-carrageenan copolymer: Synthesis and physicochemical properties
Geyik, Gulcan; Isiklan, Nuran (WILEY, 2020)kappa-Carrageenan-graft-poly(dimethylaminoethyl methacrylate) (CRG-g-PDMA) was synthesized via free-radical copolymerization under microwave irradiation.C-13-Nuclear magnetic resonance spectroscopy (C-13-NMR), fourier-transform ... -
Synthesis and characterization of pH- and temperature-sensitive materials based on alginate and poly(N-isopropylacrylamide/acrylic acid) for drug delivery
Isiklan, Nuran; Kucukbalci, Gulucan (Springer, 2016)The significant developments in the field of polymer have advanced the synthesis of polymer-based materials and have expanded their use in a wide variety of applications. Today, polymers can be designed to change their ... -
Synthesis and characterization of thermo/pH-sensitive pectin-graft-poly (dimethylaminoethyl methacrylate) coated magnetic nanoparticles
Isiklan, Nuran; Polat, Sevim (ELSEVIER, 2020)Herein, thermo- and pH-sensitive pectin-graft-poly(dimethylaminoethyl methacrylate) copolymer-coated magnetic nanoparticles were synthesized via a green and rapid synthetic approach based on microwave irradiation. Firstly, ...
