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Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion
(Comenius Univ, 2013)Purpose: The aim of this study was to investigate the effects of adrenomedullin (AM) and vascular endothelial growth factor (VEGF) on lung injury as a remote organ following skeletal muscle ischemia-reperfusion injury in ... -
Does vitamin C prevent the effects of high dose dexmedetomidine on rat erythrocyte deformability?
(Comenius Univ, 2012)Purpose: Dexmedetomidine is an anesthetic agent frequently used for sedation at the intensive care units and during general anesthesia. The purpose of our study was to investigate whether vitamin C prevents the effect of ... -
Effect of alprostadil on erythrocyte deformability in ischemia reperfusion injury
(Comenius Univ, 2015)BACKGROUND: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. Protective effect of alprostadil on local and distant organ injury due to I/R has been well-documented but ... -
Effect of apelin-13 on erythrocyte deformability during ischaemia-reperfusion injury of heart in diabetic rats
(Comenius Univ, 2017)OBJECTIVES: Erythrocyte deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of apelin-13 on erythrocyte deformability during ... -
Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury
(Comenius Univ, 2018)BACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on erythrocyte ... -
Effect of dexmedetomidine on erythrocyte deformability during ischemia-reperfusion injury of liver in diabetic rats
(Comenius Univ, 2012)Aim: The aim of this study is to evaluate the effect of dexmedetomidine on erythrocyte deformability during IR injury of liver in diabetic rats. Methods: Twenty-eight Wistar Albino rats were included in the study after a ... -
Effect of Fullerenol C60 on Erythrocyte Deformability During Ischaemia-Reperfusion Injury of Lower Extremity in Diabetic Rats
(Gazi Univ, Fac Med, 2019)Background: Fullerenol, a water-soluble C60-fullerene derivative synthesized by Chiang et al, has been demonstrated to be able to scavenge free radicals in vitro and in vivo. Although its protective effects have been already ... -
Effect of iloprost on erythrocyte deformability in rat's lower extremity undergoing an ischemia reperfusion injury
(Comenius Univ, 2013)Aim: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. The protective effect of iloprost on local and distant organ injury due to I/R has been well documented but its ... -
Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury
(Comenius Univ, 2015)Diabetes mellitus (DM) is a chronic metabolic disorder accompanied by an increase in oxidative stress. Ischaemia-reperfusion (IR) injury is a cascade of events initiated by tissue ischaemia. The cellular damage produced ... -
Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats
(Dove Medical Press Ltd, 2016)Objectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental ... -
Effects of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischemia reperfusion injury in streptozotocin-induced diabetic rats
(Comenius Univ, 2018)OBJECTIVE: In this study we aimed to evaluate the effect of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischaemia-reperfusion (IR) injury in streptozotocin-induced diabetic rats. MATERIAL ... -
The effects of iloprost on lung injury induced by skeletal muscle ischemia-reperfusion
(Comenius Univ, 2014)Purpose: The aim of this study was to investigate the effects of iloprost (I) on lung injury as a remote organ following skeletal muscle ischemia-reperfusion injury in a rat model. Materials and methods: Twenty-four Wistar ... -
Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury
(Comenius Univ, 2016)BACKGROUNDAND AIM: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross-clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to ... -
Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats
(Dove Medical Press Ltd, 2016)Background: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under ... -
The effects of low-high doses of dexmedetomidine on erythrocyte deformability in rats
(Comenius Univ, 2012)Background: Dexmedetomidine is an anesthetic agent frequently used for sedation, intensive care units, and general anesthesia. The purpose of our study was to investigate the effect of two different doses of dexmedetomidine ... -
The effects of propofol and memantine on erythrocyte deformability
(Comenius Univ, 2014)Objective: Propofol is an intravenous general anesthetic with a primary hypnotic effect. Memantine is an NMDA receptor antagonist that has been shown to reverse changes in memory and synaptic plasticity in animal models. ... -
Effects of Sevoflurane and Desflurane on Oxidant/Antioxidant Status of Young Versus Old Rat Liver Tissues
(Medwell Online, 2008)Anesthetic agents modulate on oxidant/antioxidant activity. This study aimed to evaluate the effects of desflurane and sevoflurane anesthesia on the oxidant/antioxidant activity in the liver of young and aged rats. The ... -
Effects of the general anaesthetic agent, propofol, on erythrocyte deformability
(Comenius Univ, 2010)Objectives: Propofol is an anesthetic agent frequently used for sedation and general anesthesia. The purpose of our study was to investigate the effect of propofol, a general anesthetic, on erythrocyte deformability in ... -
Flufenamic acid prevents behavioral manifestations of salicylate-induced tinnitus in the rat
(Termedia Publishing House Ltd, 2016)Introduction: Tinnitus is defined as a phantom auditory sensation, the perception of sound in the absence of external acoustic stimulation. Given that flufenamic acid (FFA) blocks TRPM2 cation channels, resulting in reduced ... -
Investigation of Effects of Propofol and Vitamin C Administration on Hepatic and Renal Tissue in Diabetic Rats
(Gazi Univ, Fac Med, 2015)Obective: A close relationship between diabetic complications and lipid peroxidation is known. It was shown that in diabetic rat pharmacodynamics and pharmacokinetics of propofol was changed. We aim to investigate effects ...