• Hypoxic Gene Signature of Primary and Metastatic Melanoma Cell Lines: Focusing on HIF-1? and NDRG-1 

  Ercin, Mustafa Emre; Bozdoğan, Önder; Çavuşoğlu, Tarık; Bozdoğan, Nazan; Atasoy, Pınar; Koçak, Mukadder (2020)

  Background: Hypoxia is an important microenvironmental factor significantly affecting tumor proliferation and progression. The importance of hypoxia is, however, not well known in oncogenesis of malignant melanoma. Aims: ...

• Prostat Adenokarsinomunda İğne Biyopsisi Ve Radikal Prostatektomi Örneklerinden Elde Edilen Gleason Skor Sonuçlarının Değerlendirilmesi 

  Devrim, Tuba; Balcı, Mahi (2019)

  Amaç: Bu çalışmada, prostat adenokarsinomunda iğne biyopsi (İB) ve radikal prostatektomi (RP) materyalleri, histopatolojik olarak karşılaştırılarak, prognozda önem arz eden Gleason skor ve grade grup sınıflamalarının ...

• Giant Adrenal Myelolipoma Occurring in the Post-Pregnancy Period 

  Atalay, Emine Sümeyye; Erpek, Hakan; Gök, Mustafa; Eliyatkın, Nuket Özkavruk (2020)

  Adrenal myelolipoma is a rare benign tumor, and contrary to most of the adrenal tumors it is an endocrinologically inactive tumor. Mature adipose tissue, and active bone marrow components identified during histopathological ...

• Local Inflammatory Response Can Predict Clinical Outcome in Patients with Curatively Resected Stage-IIB Colon Cancer: An Advanced Methodological Study 

  Zengin, Mehmet (SPRINGER, 2020)

  Purpose Although local inflammatory response (LIR) is a reliable survival marker in colon cancers (CCs), there is no consensus on its use in daily practice. We investigated the prognostic value of LIR in a highly homogeneous ...

• The concomitant use of USP28 and p53 to predict the progression of urothelial carcinoma of the bladder 

  Devrim, Tuba; Atac, Fatih; Devrim, Alparslan Kadir; Balci, Mahi (ELSEVIER GMBH, 2020)

  The Ubiquitin Specific Peptidase 28 (USP28) is a deubiquitinase involved in the DNA damage pathway. Recently, USP28 protein is reported to play roles in the mechanism of p53 action and could be a possible prognostic marker ...

• Oxidative and histopathological effects of the application of electrosurgical devices to the penile tissue of rats 

  Günal, Yasemin Dere; Boybeyi, Özlem; Atasoy, Pınar; Kısa, Üçler; Aslan, Mustafa Kemal; Bakar, Bülent; Soyer, Tutku (ELSEVIER SCI LTD, 2020)

  Introduction This study was performed to evaluate the oxidative and histopathological changes that occur following the application of electrosurgical devices (monopolar or bipolar cautery) to penile tissue. Material and ...

• Primary Unilateral Small Cell Neuroendocrine Carcinoma of the Kidney in a Dog 

  Sozmen, M.; Devrim, T.; Kuruca, N.; Inal, S.; Karaca, E.; Gulbahar, M. Y. (ELSEVIER SCI LTD, 2020)

  Primary small cell carcinomas are rare in domestic animals. A mass measuring 15 x 20 x 9 cm was detected in the left abdominal cavity of a 7.5-year-old female golden retriever. The cut surface of the excised mass showed a ...

• The Proportion of Tumour-Stroma in Metastatic Lymph Nodes is An Accurately Prognostic Indicator of Poor Survival for Advanced-Stage Colon Cancers 

  Zengin, Mehmet; Benek, Suat (SPRINGER, 2020)

  The importance of tumour microenvironment in tumour behaviour has now become clearer. This study aimed to determine the prognostic effect of the proportion of tumour-stroma (PTS) in metastatic lymph nodes of advanced-stage ...

• The role of cancer-related inflammation for prediction of poor survival in postmenopausal female patients with stage II/III colon cancer 

  Zengin, Mehmet; Karahan, Irfan (ELSEVIER, 2020)

  Objective: Cancer-related inflammation (CRI) is thought to be a successful predictor of prognosis in colon cancers (CC), but opinions on how to use it are highly variable. In this study, the role of CRI cells in survival ...

• Effects of mesenchymal stem cell and amnion membrane transfer on prevention of pericardial adhesions 

  Kabalci, Mehmet; Sahin, Mustafa; Pekcan, Zeynep; Zengin, Mehmet; Dogru, Mehmet Tolga; Kisa, Ucler (WALTER DE GRUYTER GMBH, 2020)

  Background: To investigate and compare the antiadhesive/antifibrotic effects of mesenchymal stem cells (MSC) and amnion membrane transfer (AMT) in a rat model. Material and methods: Three experimental and sham groups were ...

• Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon cancer 

  Zengin, Mehmet; Cifci, Aydin (Tubitak Scientific & Technical Research Council Turkey, 2020)

  Background/aim: Tumour budding (RI)) is considered a valuable prognostic factor in colon cancer (CC), but its use in daily practice is uncertain. W investigated the prognostic effect of RI) using preoperative biopsy specimens ...

• Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice 

  Devrim, T.; Ekici, H.; Devrim, A. K.; Sozmen, M.; Senol, A.; Bozkurt, K. M.; Yalcin, S. (Comenius Univ, 2020)

  BACKGROUND: Skin is the body's first defence against direct exposure to variety of chemicals. Polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (3-MC) are common in polluted urban air and have a potential of ...

• Differential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies 

  Balci, Mahi; Ozdemir, Gulhan (De Gruyter Poland Sp Zoo, 2019)

  Objective: The purpose of our study was to assess trophoblastic and uterine sufficiency in miscarriage pathogenesis with immunohistochemical methods and to determine if they could be used as a screening tool for the risk ...

• Rare Plasmacytoid Urothelial Carcinoma of the Bladder: Two Case Reports 

  Devrim, Tuba; Atac, Fatih; Altunkaya, Canan; Ozbek, Aye; Ozdemir, Gulhan; Eryol, Merve (Urol & Nephrol Res Ctr-Unrc, 2019)

  Plasmacytoid urothelial carcinoma is a rare and aggressive form of urothelial carcinoma characterized with delayed presentation and poor prognosis. Very few cases of this carcinoma have been reported in the literature. ...

• Tumour Budding and Tumour Stroma Ratio are Reliable Predictors for Death and Recurrence in Elderly Stage I Colon Cancer Patients 

  Zengin, Mehmet (Elsevier Gmbh, 2019)

  Aim: Tumour budding (BD) and Tumour stroma ratio (TSR) are considered valuable survival parameters for colon cancer (CC), but it is still unclear whether these parameters predict a poor prognosis. This study aimed to ...

• Periostin alters transcriptional profile in a rat model of isoproterenol-induced cardiotoxicity 

  Sozmen, M.; Devrim, A. K.; Kabak, Y. B.; Devrim, T. (Sage Publications Ltd, 2019)

  Periostin is an extracellular matrix protein from the fasciclin family that guides cellular trafficking and extracellular matrix organization. Periostin stimulates mature cardiomyocytes to reenter the cell cycle. The ...

• Ruptured cystic teratoma associated with mucinous cystadenoma in a pregnant woman 

  Aydin, O.; Pehlivanli, F.; Karaca, G.; Aydin, G.; Sayan, C. D.; Atasoy, P.; Daphan, C. E. (Wolters Kluwer Medknow Publications, 2019)

  Mature cystic teratoma is the most common ovarian neoplasm. However, mucinous cystadenoma with teratoma has been very rarely reported in literature. This case report, which is very rare, describes a clinical entity not ...

• Diagnosing atypia of undetermined significance in thyroid fine needle aspiration samples using nuclear scoring 

  Altinboga, Aysegul Aksoy; Altunkaya, Canan; Ahsen, Hilal; Gumuskaya, Berrak; Topaloglu, Oya; Ulusoy, Serap; Erdogan, Fazli (Elsevier Science Inc, 2019)

  Background Atypia of undetermined significance (AUS) is an indeterminate category in the Bethesda system for reporting thyroid cytopathology. Cytological features described as atypia are not always observed in every case, ...

• The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction 

  Kirdag, Mustafa Koray; Tuglu, Devrim; Yuvanc, Ercan; Kisa, Ucler; Balci, Mahi; Batislam, Ertan; Yilmaz, Erdal (Aves, 2019)

  Objective: In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model. Material and methods: A total of 24 ...

• What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury? 

  Sayan, Cemile Dayangan; Karaca, Gokhan; Ozkan, Zehra Sema; Tulmac, Ozlem B.; Isik, Asli Ceylan; Devrim, Tuba; Yeral, Ilkin (Wiley, 2018)

  AimThe aim of this study was to investigate the protective effect of metformin on the rat ovary against ischemia-reperfusion injury. MethodsThirty-seven female Wistar albino rats were used in the study. The rats were divided ...

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