dc.contributor.author | Arslan, M. | |
dc.contributor.author | Sezen, S. C. | |
dc.contributor.author | Turgut, H. C. | |
dc.contributor.author | Kocabiyik, M. | |
dc.contributor.author | Arpaci, H. | |
dc.contributor.author | Comu, F. M. | |
dc.contributor.author | Kavutcu, M. | |
dc.date.accessioned | 2020-06-25T18:22:30Z | |
dc.date.available | 2020-06-25T18:22:30Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Arslan, M., Sezen, S. C., Turgut, H. C., Kocabiyik, M., Arpaci, H., Comu, F. M., Ozturk, L., & Kavutcu, M. (2016). Vitamin C ameliorates high dose Dexmedetomidine induced liver injury. Bratislavske lekarske listy, 117(1), 36–40. | en_US |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://doi.org/10.4149/BLL_2016_008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/6768 | |
dc.description | Arslan, Mustafa/0000-0003-4882-5063 | en_US |
dc.description | WOS: 000370112600008 | en_US |
dc.description | PubMed: 26810168 | en_US |
dc.description.abstract | BACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses. MATERIAL AND METHODS: Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCI intraperitoneally (ip), Dexmedetomidine 5 mu g.kg(-1) (ip), Dexmedetomidine 5 mu g.kg(-1) ip plus Vitamin C (100 mng.kg(-1)), Dexmedetomidine 10 mu g.kg(-1) ip and Dexmedetomidine 10 mu g.kg(-1) ip plus Vitamin C (100 mg.kg-1). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated. RESULTS: Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were significantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were significantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was significantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively). CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pretreatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30). Text in PDF www.elis.sk. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Comenius Univ | en_US |
dc.relation.isversionof | 10.4149/BLL_2016_008 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Dexmedetomidine | en_US |
dc.subject | vitamin C | en_US |
dc.subject | liver histopathology | en_US |
dc.subject | MDA | en_US |
dc.subject | SOD | en_US |
dc.subject | rat | en_US |
dc.title | Vitamin C ameliorates high dose Dexmedetomidine induced liver injury | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 117 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 36 | en_US |
dc.identifier.endpage | 40 | en_US |
dc.relation.journal | Bratislava Medical Journal-Bratislavske Lekarske Listy | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |