| dc.description.abstract | Aim: Tumour budding (BD) and Tumour stroma ratio (TSR) are considered valuable survival parameters for colon cancer (CC), but it is still unclear whether these parameters predict a poor prognosis. This study aimed to determine the survival effect of TB and TSR in elderly stage I CC patients. Methods: We evaluated these parameters in eighty-eight stage I CC patients who underwent surgical treatment alone between 1998 and 2015. The relationship between these parameters and age was investigated. Model A was used for methodology. Results: In elderly patients (>= 68), these parameters obtained more successful results for following analysis: relationship between prognostic factors [lymphatic invasion (BD, p = 0.003; TSR, p = 0.003), perineural invasion (BD, p = 0.016; TSR, p = 0.004), tumour deposites (BD, p = 0.005; TSR, p = 0.033), MSI (BD, p = 0.031; TSR, p = 0.012), etc.], correlation of estimates (BD, r=0.724; TSR, r = 0.703), and reproducibility of study (BD [Kappa (kappa)] = 0.53-0.75; TSR (kappa) =0.56-0.71). Also, the cut-off values were useful for BD (area of under ROC (AUC)= 0.816 [0.707-0.925]) and TSR (AUC =0.810 [0.697-0.924]). In univariate analysis, in elderly patients, these parameters had a poor 5-year survival for RFS (p < 0.001[BD], p = 0.001 [TSR] ), OS (p < 0.001[BD], p =0.005[TSR]), and LR (p =0.008[BD], p = 0.034[TSR]). Multivariate analysis confirmed that these parameters are independent worse predictors for RFS (BD: 1.42[HR], p=0.002; TSR: 1.50[HR], p=0.001), OS (BD: 1.38[HR], p = 0.014; TSR: 1.42[HR], p=0.005), and LR (BD: 1.61[HR], p=0.034) in elderly patients. Conclusions: Our results confirm that BD and TSR are reliable indexes for poor survival in elderly stage I CC patients. We recommend using model A for successful results and standardization. | en_US |
