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  • Küçük Resim
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    Alterations in serum thiol-disulfiide homeostasis and ischemiamodifiied albumin concentrations in clinical canine parvoviral enteritis
    (Tubitak Scientific & Technological Research Council Turkey, 2024) Şenel, Yasin; Terzi, Osman Safa; Kara, Erdal; Erel, Özcan; Neşelioğlu, Salim; Ceylan, Ebubekir
    Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy puppies (n = 34) were compared. Canine parvoviral enteritis and control groups showed a statistically significant difference in thiol disulfide levels (p < 0.01), while no significant difference was observed in ischemia modified albumin levels between the two groups. As a result of this study, a picture contradictory to the literature information was discovered; it is believed that integrating research on oxidative stress at various stages of disease progression, including the early stage, clinical period and recovery processes may provide more information about the dynamics of oxidative stress during disease progression.
  • Küçük Resim
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    Dynamic thiol-disulphide homeostasis and ischemia modified albumin levels in neonatal calf diarrhea
    (Ankara Univ, 2023) Terzi, Osman Safa; Kara, Erdal; Şenel, Yasin; Ceylan, Ebubekir; Neşelioğlu, Salim; Erel, Özcan
    The aim of this study was to determine dynamic thiol-disulphide homeostasis (TDH) parameters and ischemia modified albumin (IMA) levels in calves with neonatal diarrhea and compare with healthy controls. A total of 50 calves were included in the study. There were 25 calves in both diarrhea and healthy groups. Serum native thiol, total thiol, disulfide and IMA levels were measured using new methods. Native thiol (P=0.025) and total thiol (P=0.041) values decreased significantly in calves with neonatal diarrhea compared to the healthy control group. Disulphide (P=0.133), disulphide/native thiol ratio (P=0.001) and IMA (P=0.0018) parameters were lower in healthy group, and the difference between the two groups was significant for the parameters other than disulphide. This study shows that TDH is impaired in neonatal calf diarrhea and IMA levels are increased due to oxidative stress.
  • Küçük Resim
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    Evaluation of Colostral Passive Immune Transfer Success in Turkish Kangal Shepherd Dogs
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2024) Kara, Erdal; Öcal, Naci; Duru, Özkan; Duru, Sibel Yasa; Şenel, Yasin
    The aim of this study was to investigate the passive immune transfer process and its effects in Turkish Kangal shepherd dogs. The material of the study consisted of 15 dams and their 138 offspring in the region of Central Anatolia, Turkiye. Blood samples were collected from the surviving puppies at 48 +/- 4 h postpartum and IgG levels were measured using the ELISA method. Before the blood samples were collected, 34 of the puppies (26.64%) died, 56 of the 104 puppies (40.58%) whose blood samples were collected and IgG analyses were done died prior to weaning, and 48 (34.78%) survived until weaning. All of the analyzed blood samples had IgG levels above 230 mg/dL and there was no passive transfer failure. The average blood IgG level of the puppies was 664.86 mg/dL. The effects of litter size and birth season on passive transfer success were statistically significant (P<0.05), while maternal age and the sex of the puppy were not significant (P>0.05). There was no correlation between the average blood IgG levels of the puppies and group mortality rates (r =-0.44). In conclusion, while the rate of passive transfer success for Turkish Kangal shepherd dogs was found to be high compared to other breeds, the high rate of mortality among the puppies suggested that dams and their litters should be cared for more carefully in the neonatal period.
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    Öğe
    Yerli Kara ve İsviçre Esmeri Irkı Sığırların Kolostrum Kalitesinin Karşılaştırılması
    (2020) Kara, Erdal; Terzi, Osman Safa; Şenel, Yasin; Ceylan, Ebubekir
    Ruminant plasentaları sindesmokoryal tipte olduğu için maternal sirkülasyonla yavru sirkülasyonubirbirinden ayrılmaktadır. Bu sebeple yenidoğan buzağılar neonatal dönem olarak da isimlendirilendoğumu takiben ilk 28 günlük periyotta, annelerinin kolostrumundan alacakları bağışıklıkbileşenlerine ihtiyaç duyarlar. Pasif immun transfer başarısı için toplam kolostralImmunlobülinlerinlerin %85-90’ını oluşturan Immunglobülin G’nin kolostrumdaki miktarı kalitenoktasında belirleyicidir. Çalışmanın amacı; yerli gen kaynaklarımızdan olan Yerli Kara ırkı sığırlarile kombine verimli bir kültür ırkı olan İsviçre Esmeri’nin kolostrum kalitelerinin karşılaştırılmasıdır.Çalışmanın hayvan materyalini 40 saf Yerli Kara sığır ve 39 saf İsviçre Esmeri sığır oluşturdu.Kolostrum Immunglobulin G seviyesi ELISA yöntemi kullanılarak belirlendi. Yerli Kara ve İsviçreEsmeri sığırların tanımlayıcı istatistik verilerine göre ortalama Immunglobulin G konsantrasyonlarısırasıyla; 133.1±77.28 mg/mL, 74.60±28.44 mg/mL olduğu tespit edildi. İki grup arasındakiImmunglobulin G verileri bağımsız t testi ile karşılaştırıldığında istatistiksel olarak önemli olduğutespit edildi (P<0.001). Sonuç olarak; bu çalışmayla Yerli Kara ırkının kolostrum kalitesinin sütüretimi yüksek olan İsviçre Esmeri ırkına oranla oldukça yüksek olduğu görüldü.