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Öğe A Case of Early Infantile Epileptic Encephalopathy Due to KCNQ2 Gene Mutation Presenting With Episodes of Hiccups(Cureus Inc, 2022) Alan, Serdar; Vural, Sevde Nur; Aliefendioglu, Didem; Senbil, NesrinNeonatal epilepsy syndromes are responsible for only 15% of the cases of neonatal seizure. An underlying genetic disorder can be detected in approximately 42% of this subgroup. KCNQ2 gene-associated epilepsies are very rare and more common presentations are self-limited familial neonatal epilepsy (SLFNE) and early infantile epileptic encephalopathies (EIEE). The most common initial seizure semiologies are tonic seizures with or without autonomic symptoms in EIEE resulting from KCNQ2 gene mutation. It is characterized by early neonatal onset seizures with suppression burst pattern on electroencephalogram and typically results in severe developmental delay. Therapeutic options for infants with KCNQ2-related EIEE are limited and there is no consensus about it in the literature. Herein, the neonate with EIEE with unexpected episodes of hiccups due to novel mutation of the KCNQ2 gene, which was reported second time, was presented and antiepileptic treatment strategies were discussed in the light of current literature.Öğe A key challenge in gestational diabetes screening: resistance to oral glucose tolerance test screening and implications for neonatal health(2021) Tursun, Serkan; Yeral, Mahmut İlkin; Yıldız, Volkan; Ünal, Elif Gökçe; Guzoglu, Nilufer; Aliefendioglu, DidemObjective: Gestational diabetes mellitus (GDM) is the most common endocrine disorder in pregnancy, and the number of pregnant women resistant to oral glucose tolerance test (OGTT) has increased significantly in recent years. In this study, we investigated the extent of resistance to OGTT screening among pregnant women followed-up in our hospital and the effects of this situation on the newborn. Materials and Method: We conducted this study with pregnant women and their babies who were regularly followed up in the Obstetrics and Gynecology Department and Pediatrics Department of our hospital between December 1, 2015, and December 31, 2017. While we included those who did not accept an OGTT in the study group (Group 1), and we created the control group with those who accepted the test. Besides, the control group was divided into two groups as those accepted as GDM (Group 2) and normal (Group 3). Ultimately, we scrutinized the relationship between the OGTT and clinicopathological findings. Results: We included a total of 906 pregnant women and their babies in the study. Of women, 374 (41.3%) did not accept the test. The cesarean (C/S) delivery rate was significantly lower in the babies of mothers who did not have an OGTT (p<0.05). In addition, the hospitalization rate of the newborn babies of mothers who had an OGTT but did not have gestational diabetes was significantly lower than the other two groups (p<0.05). Conclusion: Our study revealed that resistance to the OGTT was a far-reaching issue and may lead to an increase in the hospitalization of newborns. Our results suggested that the inability to perform OGTT may have been due to some unidentified problems.Öğe A New Parameter for Erythropoiesis: The Relationship of Immature Reticulocyte Fraction Values in Cord Blood with Clinical Factors and Reference Values for Newborns(Duzce Univ, Fac Medicine, 2023) Dursun, Zarife Esra; Guzoglu, Nilufer; Kisa, Ucler; Davutoglu, Salih; Aliefendioglu, DidemAim: The immature reticulocyte fraction (IRF) is a new parameter for the reticulocyte maturity index, representing an independent parameter of erythropoiesis that may be useful to better assess erythropoietic activity in neonates. In this study, the relationship between IRF values and clinical features in newborns was investigated and reference values were obtained. Material and Methods: Newborns between 28-40 weeks of gestation were included in this prospective study. At birth, maternal venous and cord blood samples were obtained for measurements of complete blood count (CBC), blood gases, and plasma concentrations of various biochemical parameters. Results: A total of 123 newborns, 99 term and 24 preterm, were included in the study. When the laboratory characteristics of the premature and term babies were compared according to their gestational weeks, while the median IRF value of cord blood was higher in term babies than in premature babies (p=0.039), other laboratory findings did not differ significantly. The median IRF value was 0.52 (range, 0.15-1.00) in term infants and 0.34 (range, 0.16-0.76) in preterm infants. IRF reference values for the term and preterm newborns were determined in cord blood. Moderately positive correlations were observed between the IRF levels and both the RDW (r=0.423, p<0.001) and the CRP (r=0.389, p<0.001) levels. Conclusion: The results of this study showed that newborns' IRF values were not affected by maternal variables and changed with the week of birth. The results of this study might be considered a guide for future studies using IRF value in newborns.Öğe Acute Kidney Injury in Very Preterm Infants: A Cohort Study in a Level III NICU(Galenos Publ House, 2024) Güzoğlu, Nilüfer; Tandircioglu, Ümit Ayşe; Bulut, Aye; Acar, Banu Çelikel; Aliefendioglu, DidemBACKGROUND/AIMS: Acute kidney injury (AKI) is not rare among preterm infants in neonatal intensive care units (NICU). It raises mortality and morbidity in NICUs and also chronic kidney disease in the long term. The aim of this study was to define the incidence of clinical characteristics and the course of AKI in very preterm infants. MATERIALS AND METHODS: A retrospective cohort study was conducted in a level III NICU in a university hospital. All very preterm infants born in the same hospital during the study period were included in this study. Patient data were taken from the medical records. AKI diagnosis was made using the neonatal-modified Kidney Disease Improving Global Outcomes (KDIGO) criteria. RESULTS: AKI was diagnosed in 20 very preterm infants (42%). The median time of AKI diagnosis was 4.5 days of life (between 2-12 days). While there were 8 infants with AKI when the diagnosis was made based on the serum creatinine (Cr) level being over 1.5, the diagnosis of AKI increased to 20 with the use of the KDIGO criteria. Need for resuscitation in the birth room, patent ductus arteriosus, the number of cases of apnea, desaturation episodes, sepsis, hypotension, inotropic support, and sepsis rates were significantly higher in the AKI group. Days hospitalized among survivors were longer and mortality was higher in the AKI group than in the non-AKI group (p=0.042, p<0.0001 respectively). CONCLUSION: The neonatal KDIGO criteria are beneficial and also informative in diagnosing and staging AKI. Close follow-up of urine output and Cr levels especially in the first days is essential in very preterm infants.Öğe Anesthesia for a child with Walker-Warburg syndrome(Elsevier Science Inc, 2014) Kose, Emine Arzu; Bakar, Bulent; Ates, Gokay; Aliefendioglu, Didem; Apan, AlpaslanBackground and objectives: Walker-Warburg Syndrome is a rare, autosomal recessive con-genital muscular dystrophy manifested by central nervous system, eye malformations andpossible multisystem involvement. The diagnosis is established by the presence of four crite-ria: congenital muscular dystrophy, type II lissencephaly, cerebellar malformation, and retinalmalformation. Most of the syndromic children die in the first three years of life because ofrespiratory failure, pneumonia, seizures, hyperthermia and ventricular fibrillation. Case Report : The anesthetic management of a two-months-old male child listed for electiveventriculo-peritoneal shunt operation was discussed. Conclusions : A careful anesthetic management is necessary due to the multisysteminvolvement. We reported anesthetic management of a two-months-old male child withWalker-Warburg Syndrome who was listed for elective ventriculo-peritoneal shunt operation. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rightsreserved.Öğe Breast-feeding-associated hypernatremia: Retrospective analysis of 169 term newborns(Wiley, 2008) Unal, Sevim; Arhan, Ebru; Kara, Nazli; Uncu, Nermin; Aliefendioglu, DidemBackground: The aim of the present paper was to define the incidence, complications, morbidity and mortality of hypernatremic dehydration due to inadequate breast-feeding in a neonatal intensive care unit. Methods: A retrospective study was carried out between 2002 and 2005, to identify the term breast-fed neonates with serum sodium level >= 150 mEq/L at the Ministry of Health Ankara Diskapi Children's and Research Hospital. Results: The incidence of hypernatremic dehydration secondary to inadequate breast-feeding was 4.1%, occurring in 169 term infants among 4136 hospitalized term neonates with the following characteristics: mean gestational age, 39.1 weeks (37-42 weeks); birthweight, 3352 g (2200-4500 g); mother's age, 26.1 years (17-38 years); weight loss, 15.9% (5.4-32.7%); proportion of spontaneous vaginal deliveries, 75.7%; and proportion of first-time mothers, 74.6%. Major presenting symptoms were neonatal jaundice (47.3%) and poor infant suck (29.6%). The median sodium; blood urea nitrogen (BUN); and creatinine levels on admission were 155 mmol/L (150-194 mmol/L), 35 mg/dL (7-253 mg/dL), and 0.9 mg/dL (0.2-10 mg/dL), respectively. Major complications were as follows: acute renal failure, 82.8%; elevated liver enzymes, 20.7%; disseminated intravascular coagulation, 6.5%; brain edema, 5.2%; intracranial hemorrhage, 3.6%; cavernous sinus thrombosis, 1.2%; and bilateral iliac artery thrombosis, 0.6%. Ten patients (5.9%) developed seizure within the first 24 h of rehydration therapy with a mean sodium decrease of 11.9 mmol/L per day (4-19 mmol/L per day). Two patients (1.2%) died. There were positive correlation between weight loss and serum sodium, BUN, bilirubin levels (P < 0.01); there was no correlation between weight loss and mothers' age, education level, delivery route, or first-born status (P > 0.05). Conclusions: Hypernatremic dehydration in neonates due to inadequate breast-feeding is a serious, potentially devastating and life-threatening disorder, and can damage the central nervous system. Follow up of infants for adequate breast-feeding is important. Pediatricians must maintain a high level of suspicion, especially in cases of pathologic infant weight loss after delivery.Öğe Can cerebrospinal fluid uric acid levels differentiate intraventricular hemorrhage from traumatic tap?(Karger, 2006) Aliefendioglu, Didem; Gürsoy, Tuğba; Hayran, K. Mutlu; Aslan, Ayşe TanaObjective: To measure blood and cerebrospinal fluid (CSF) uric acid (UA) levels of neonates with intraventricular hemorrhage (IVH), and to examine whether or not UA can be used to differentiate traumatic tap from IVH. Material and Methods: The control group (n = 19, group I) consisted of neonates presenting with signs requiring analysis of CSF but whose CSF indices proved to be normal. Traumatic taps (n = 15, group II) were mimicked by adding 2 drops of homologous blood to normal CSF samples. The IVH group (n = 21, group III) consisted of neonates who had been diagnosed by cranial ultrasonography or computed tomography scans. Data are presented as median ( range). Results: There was no significant difference between groups with respect to serum UA levels. While no significant difference was observed between CSF UA levels of the control [0.6 (0.1-1.8) mg/dl] and traumatic tap group [0.5 (0.3-1.1) mg/dl], the IVH group [1.6 (0.7-6.9) mg/dl] was found to have significantly higher CSF UA levels than groups I and II. Furthermore, although there were significant correlations between serum and CSF UA levels in the control and traumatic tap groups, no correlation was observed in the IVH group. Conclusion: CSF UA levels are increased in neonates with IVH and they may be used to differentiate a real hemorrhage from a traumatic tap. Copyright (c) 2006 S. Karger AG, Basel.Öğe Can Resistin be a New Indicator of Neonatal Sepsis?(Elsevier Taiwan, 2014) Aliefendioglu, Didem; Gursoy, Tugba; Caglayan, Osman; Aktas, Alev; Ovali, FahriBackground: Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine might play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels of premature newborns with sepsis, which can also cause inflammatory response. The objective of this study was to evaluate whether resistin can be used as an indicator in neonatal sepsis of preterm babies. Materials and methods: Forty-three premature newborns considered to have sepsis were included in the study. Forty-three gestational and postnatal age- and sex-matched premature newborns without premature prolonged rupture of membrane or sepsis served as controls. Results: The median resistin and interleukin-6 (IL-6) levels of the premature babies with sepsis were 85.9 ng/mL and 342.7 pg/mL, respectively, and were higher than those of the control group (29.9 ng/mL and 17.7 pg/mL, respectively). The sensitivity, specificity, positive, and negative predictive values for resistin were 73.7%, 45.8%, 68.3%, and 52.4%, respectively. Conclusion: Resistin levels were higher in premature newborns with sepsis and correlated with IL-6 levels, which is an indicator of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis. However, it has limited value when compared with the other inflammatory markers including C-reactive protein, procalcitonin, and IL-6. Copyright (C) 2013, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Case 3: Fetal intracardiac tumour - A feature of a genetic disease? - Diagnosis: Tuberous sclerosis(Wiley, 2006) Misirlioglu, Emine Dibek; Aliefendioglu, Didem; Alpan, Nursel; Güven, Alev; Peltek, Nur…Öğe Caudate lobe of the liver as the only content of the umbilical cord hernia(Wiley-Blackwell, 2015) Boybeyi, Ozlem; Ozmen, Ismail; Gunal, Yasemin Dere; Aslan, Mustafa Kemal; Aliefendioglu, Didem…Öğe Cerebral MRI findings in neonatal hypoglycemia(2005) Bademci, Gülşah; Yücel, Engin; Aliefendioglu, DidemMetabolic disturbances such as anoxia and hypoglycemia may adversely alter the development of the neonatal brain. While rapid and appropriate diagnosis with adequate therapy has a good prognosis; delayed detection and/or inappropriate therapy increases the risk of the development of irreversible brain damage. Magnetic resonance imaging (MRI) studies are essential in neonatal hypoglycemia to define the characteristics and severity of cerebral lesions after hypoglycemia, to decide the efficacy of preferred treatment modality and to predict the neurologic outcome. Although acute and long-term radiologic abnormalities associated with hypoglycemic episodes in children and adults are well documented, the details of the situation for neonatal hypoglycemia are still emerging. In this review, the impact of MRI findings of neonatal hypoglycemia on diagnosis, monitoring of treatment and neurologic outcome was discussed. © 2005 - IOS Press and the authors. All rights reserved.Öğe Cerebral MRI findings in neonatal hypoglycemia(Georg Thieme Verlag Kg, 2005) Bademci, Gulsah; Yucel, Engin; Aliefendioglu, DidemMetabolic disturbances such as anoxia and hypoglycemia may adversely alter the development of the neonatal brain. While rapid and appropriate diagnosis with adequate therapy has a good prognosis; delayed detection and/or inappropriate therapy increases the risk of the development of irreversible brain damage. Magnetic resonance imaging (MRI) studies are essential in neonatal hypoglycemia to define the characteristics and severity of cerebral lesions after hypoglycemia, to decide the efficacy of preferred treatment modality and to predict the neurologic outcome. Although acute and long-term radiologic abnormalities associated with hypoglycemic episodes in children and adults are well documented, the details of the situation for neonatal hypoglycemia are still emerging. In this review, the impact of MRI findings of neonatal hypoglycemia on diagnosis, monitoring of treatment and neurologic outcome was discussed.Öğe Congenital Microvillus Inclusion Disease in the Differential Diagnosis of Intractable Metabolic Acidosis(Elsevier Taiwan, 2017) Guzoglu, Nilufer; Aliefendioglu, Didem; Gulerman, Fulya; Gucer, Safak; Kaymaz, Figen…Öğe Could Lower Bone Turnover be a Cause of Chest Pain During Childhood?(Springer, 2010) Şanli, Cihat; Akalın, Nursel; Koçak, Ülker; Erol, Reyhan; Albayrak, Meryem; Aliefendioglu, Didem; Hizel, SeldaChest pain, a frequent complaint during childhood, rarely originates from a cardiac pathology. Although it usually is idiopathic, it also could be associated with psychogenic, musculoskeletal, respiratory, and digestive disorders. This study aimed to investigate a possible relation between bone mineral density and chest pain in children. Bone mineral density and bone metabolism parameters were measured for 50 children with chest pain, and the findings were compared with those for 40 age- and sex-matched healthy children. Most of the cases (64%) were in the idiopathic group, and musculoskeletal chest pain was the second most frequent complaint (12%). Although bone mineral densities and osteocalcin levels did not differ significantly between the whole chest pain group and the control group, both were found to be lower in the musculoskeletal chest pain group than in other groups and the control group (p < 0.05). Musculoskeletal chest pain may be related to reduced bone mineral metabolism, and monitoring of risk factors is of particular importance.Öğe Differences in Possible Risk Factors, Treatment Strategies, and Outcomes of Neonatal Pneumothorax in Preterm and Term Infants(Aves, 2024) Tandircioglu, Umit Ayse; Koral, Umran; Guzoglu, Nilufer; Alan, Serdar; Aliefendioglu, DidemObjective: The study aimed to compare the risk factors, treatment strategies, and early outcomes of symptomatic neonatal pneumothorax (NP) between preterm and term newborns. Materials and Methods: This retrospective cross-sectional study was conducted in a neonatal intensive care unit between 2015 and 2022, consisting of hospitalized neonates with symptomatic NP. The cases were divided into three groups according to their gestational ages: <34(0/7 )(group 1), 34(0/7)-36(6/7) (group 2), and >= 37(0/7) weeks (group 3). Risk factors, treatment strategies, and mortality rates of the study groups were compared using Kruskal-Wallis analysis. Results: Fifty-nine infants with a diagnosis of symptomatic NP were included in the study. The number of participants was as follows: 25 (42.3%) in group 1, 18 (30.5%) in group 2, and 16 (27.1%) in group 3. The need of delivery room (DR) resuscitation was significantly higher in group 1 (40%, P = .003). The surfactant administration rate was significantly higher in group 1 when compared to group 2 and group 3 (68% vs. 22% and 19%, respectively), P < .001. Similarly, the invasive mechanical ventilation percentage was significantly higher in group 1 than group 2 and group 3, P = .014. However, compared to group 3 (63%), the percentage of chest drain insertion (CDI) need was significantly higher in group 1 (96%) and group 2 (89%) (P = .014). Conclusion: Exposure to DR resuscitation and the need for surfactant are the most common risk factors for NP in preterm infants. Although oxygen and/or needle aspiration treatments are less invasive in symptomatic NP, the improvement rate without CDI is very low in preterm infants born before 34 weeks of gestational age.Öğe Do cerebral blood flow velocities change in iron deficiency anemia?(Lippincott Williams & Wilkins, 2007) Aliefendioglu, Didem; Yilmaz, Sevda; Misirlioglu, Emine Dibek; Saygi, Semra; Özdoğan, Selver; Koçak, ÜlkerInfants with iron deficiency had lower scores when tested for mental and motor development than their peers with better iron status. The aim of this study was to examine cerebral blood flow velocity in infants with iron deficiency anemia. Thirty-six infants (27 male, 9 female) with iron deficiency anemia, aged 6 to 36 months were divided into 2 groups according to the hemoglobin (Hb) values [group 1 (n = 23) Hb < 10 g/dL and group 2 (n = 13) 11 > Hb >= 10g/dL]. In anterior and middle cerebral arteries only end-diastolic velocity (EDV) was increased in group 1 as compared with group 2 (P = 0.05 and P = 0.016, respectively), whereas in posterior cerebral artery both EDV and peak-systolic velocity were different between the groups (P = 0.024 and P = 0.004). Both peak-systolic velocity and EDV showed significant correlation with Hb level in the posterior cerebral artery (r = -0.38, P = 0.023 and r = - 0.35, P = 0.037) but not in the anterior and middle cerebral arteries. Increased cerebral blood flow velocities in children with lower Hb values may be due to increased cardiac output, decreased vascular resistivity caused by anemia.Öğe Effect of phototherapy on gastrointestinal smooth muscle activity and oxidative stress(Springer, 2011) Soyer, Tutku; Aliefendioglu, Didem; Aktuna, Zuhal; Caglayan, Osman; Aydos, Tolga Resat; Cakmak, MuratAim To evaluate the effect of phototherapy on gastrointestinal smooth muscle activity and oxidative stress. Methods Wistar albino rats (n = 18, in the first 7 days of life) weighing 7 +/- 2 g with both sexes were included in the study. The animals were randomized into three groups. In control group (CG), median laparotomy was performed to obtain 1 cm of jejunum, terminal ileum and colonic segments. In the phototherapy group (PTG), led phototherapy with a wave density of 40 mu w/cm(2)/nm were used (Bilitron 3006, Fanem, Brasil). The efficacy surface of phototherapy was 30-40 cm and the exposure distance was 30 cm. The duration of phototherapy was 24 h. Sham group (SG) received white light with the same wave density and exposure distance. The oxidative stress markers and contraction responses were investigated from intestinal segments obtained from experiments. Results The jejunum segments showed significantly lowered contraction response to carbachol in SG when compared to CG and PTG (p < 0.05). Decreased contractile response to KCl was detected in both SG and PTG in terminal ileum segments. MDA levels showed no difference between groups (p > 0.05). Total sulfhydryl (T-SH) levels were found significantly increased in PTG when compared to CG and SG (p < 0.05). When NO levels were evaluated, NO levels were found decreased in PTG and SG with respect to CG (p < 0.05). Conclusion PT may cause various alterations in oxidant/antioxidant system in intestinal segments. Unlike to clinical findings, decreased contractile responses were detected in rat gastrointestinal smooth muscles after PT.Öğe Effect of phototherapy on growth factor levels in neonatal rat skin(W B Saunders Co-Elsevier Inc, 2011) Soyer, Tutku; Ayva, Sebnem; Aliefendioglu, Didem; Aktuna, Zuhal; Aslan, Mustafa Kemal; Senyucel, Mine Fedakar; Cakmak, MuratAim: Neonates undergoing surgery may receive phototherapy (PT) for the treatment of hyperbilirubinemia. Although the effects of PT on neonatal structures are well documented, the effect of PT on wound healing has not been previously evaluated. An experimental study was performed to evaluate the effect of PT on growth factor levels responsible for wound healing in neonatal rat skin. Materials and Methods: Eighteen Wistar newborn rats (7 +/- 2 g) were included in the study. Rats were randomized into 3 groups: control (CG), PT, and sham (SG) (n = 6). Both groups had 1-cm median dorsal skin incision. In CG, 1 x 1 cm of dorsal skin was sampled including the incised skin. The PT group received 5 banks of blue light (wave density, 30-40 mu w/cm(2) per nanometer; exposure distance, 45 cm). Phototherapy was started 24 hours after birth and exposed during light period (mean duration, 21 hours to 15 minutes perpendicular to 2 hour to 1.5 minutes). Sham group consisted of animals that received a bank of white light with same exposure distance and a total duration of 26 hours to 18 minutes +/- 3 hours to 9.1 minutes. After exposure, 1 x 1 cm dorsal skin samples were obtained from both PT and SG groups, including the median incision. The effect of PT was evaluated with the expressions of vascular endothelial growth factor (VEGF), its receptor (VEGF receptor), and transforming growth factor beta (TGF-beta) in endothelial vessels and fibroblasts of neonatal skin samples. Results: There was no significant difference between groups in VEGF receptor and transforming growth factor beta expressions. The VEGF levels in endothelial vessels were significantly decreased in PT and SG when compared with CG (P < .05). Conclusion: Vascular endothelial growth factor is a mediator of angiogenesis and may decrease in neonatal rat skin after light exposure. It can be suggested that decreased levels of VEGF after PT application may alter angiogenesis and also may adversely affect the healing features of neonatal skin. (C) 2011 Elsevier Inc. All rights reserved.Öğe Elevations of serum aminotransferase in muscular dystrophy(Aves, 2008) Dibek Misirlioglu, Emine; Albayrak, Meryem; Aliefendioglu, Didem…Öğe Evaluation of Patients with Neonatal Thrombosis(Springer India, 2023) Guzoglu, Nilufer; Albayrak, Meryem; Aliefendioglu, DidemThe aim of the study is to characterize acquired and genetic risk factors and to give an account of the hereditary thrombophilia panel in neonatal thrombosis. All newborns diagnosed with neonatal thrombosis in a level III NICU were included in this retrospective cohort study. A total of 1850 patients were admitted to the NICU during the 5-y period; and 11 patients were diagnosed with thrombosis (0.58%). The most common risk factors were central venous catheter placement, hypoxia and prematurity and related complications, and sepsis. Four patients were investigated regarding the inherited risk factors for thrombosis. In these 4 patients, homozygous A1298C alleles of MTHFR and heterozygous FXIIIV34L mutations; homozygous PAI-SERPINE1 and heterozygous MTHFRA1298C mutations; compound heterozygous mutations of MTHFRC677T and MTHFRA1298C; and compound heterozygous mutations of MTHFRC677T, MTHFRA1298C, and PAISERPINE1 were detected respectively. In conclusion, neonatal thrombosis is multifactorial; newborns with acquired risk factors may also have hereditary risk factors.Trial InformationClinicalTrials.govIdentifier: NCT05367466
