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Öğe Androgen receptor status in lesional and normal skin of patients with rosacea(Blackwell Publishing Ltd, 2004) Erkek, E.; Bozdogan, O.; Kocak, M.; Birol, A.; Atasoy, P.…Öğe Bcl-2-related proteins, (alpha)-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas(Taylor & Francis As, 2002) Bozdoğan, Ö.; Erkek, E.; Atasoy, P.; Koçak, M.; Birol, A.; Caydere, M.Aberrant expression of bcl-gene products has been implicated in the development of non-melanoma skin cancers. Recently, altered expression of alpha-smooth muscle actin has been proposed as predictive of tumour behaviour in basal cell carcinomas. The purpose of this study was to compare the aggressive and non-aggressive basal cell carcinomas in terms of bcl-gene products and alpha-smooth muscle actin expression. Fifty excisional biopsy samples were studied by immunohistochemical technique for the differential expressions of bcl-2, bax, bcl-x and alpha-smooth muscle actin. Bcl-2, bcl-x and bax were expressed in 34 (68%), 38 (76%) and 41 (82%) specimens, respectively. Immunoreactivity for alpha-smooth muscle actin was noted both in tumour nests (64%) and within the stroma (54%). There was a significant difference between aggressive and non-aggressive basal cell carcinomas in terms of bcl-2 and stromal alpha-smooth muscle actin immunoreactivity. Non-aggressive basal cell carcinomas display a concordant expression of bcl-family proteins, whereas aggressive tumours reveal a discordant pattern. An increased expression of stromal alpha-smooth muscle actin with a concomitant decrease or loss of bcl-2 expression may be highly suggestive of aggressiveness in basal cell carcinoma.Öğe Bilateral elastofibroma dorsi: proper positioning for an accurate diagnosis(Elsevier Science Bv, 2002) Kara, M.; Dikmen, E.; Kara, S.A.; Atasoy, P.Elastofibroma dorsi is a rare, slow-growing, ill-defined soft tissue tumor of the chest wall, most commonly located beneath the rhomboid major and latissimus dorsi muscles. It is usually unilateral, and bilateral involvement occurs in only 10% of patients. We report herein a case of a 56-year-old woman with bilateral elastofibroma dorsi. The patient was found to have bilateral involvement of the tumor following a physical examination with proper positioning. An elastofibroma should be considered in the differential diagnosis of tumors deeply located at the periscapular area. Meticulous physical examination may reveal a nonpalpable coexisting tumor with deep subscapular location and help the accurate diagnosis of bilateral elastofibroma dorsi, hence preventing a secondary operation. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe Confluent and reticulated papillomatosis: favourable response to low-dose isotretinoin(Wiley, 2009) Erkek, E.; Ayva, S.; Atasoy, P.; Emeksiz, M. C.…Öğe Continence recovery time after radical prostatectomy: implication of prostatic apical tumor(Edizioni Minerva Medica, 2013) Sipal, T.; Tuglu, D.; Yilmaz, E.; Atasoy, P.; Batislam, E.Aim. Despite the role of prostatic apex on post-radical prostatectomy incontinence (PPI) has been encountered, the impact of prostatic apex tumor on urinary recovery has been poorly adressed. We aimed to evaluate the effect of prostatic apex tumor on PPI. Methods. Between January 2008 and December 2011, a total 36 consecutive patients who underwent open retropubic radical prostatectomy (RRP) for prostate adenocancer (PCa) were analyzed. The patients were divided into two groups according to the presence of prostatic apical tumor. Urinary incontinence was assessed at regular intervals following RP using validated Incontinence Questionnaire-Short Form and 24-hour pad use based on patients' reports. Urinary continence was defined as wearing no pads. All patients' functional and oncological data were recorded. Results. Overall urinary continence rate at one year was 90%. There was a statistical difference between two groups in terms of urinary recovery (P=0.024). The 1 week, 1 month, 3 month, 6 months and 1 year postoperative continence rates were 28%, 50%, 85%, 92.9% and 92.9%, respectively, in patients with apex infiltration (-) group, compared with 0%, 22.7%, 45.5%, 72.7% and 86.4%, respectively, in patients with infiltration (+) group. Conclusion. The results provided that infiltration of the prostatic apex could significantly affect urinary continence recovery time after RP and advanced pathologic stage could be a risk for PPI.Öğe Etodolac-induced multiple bullous fixed drug eruption(Wiley-Blackwell, 2011) Kalkan, Koca, I; Kalpaklioglu, A.; Atasoy, P.; Karabulut, A.…Öğe Examination of Bcl-2, Bcl-X and bax protein expression in psoriasis(Blackwell Publishing Ltd, 2003) Koçak, M.; Bozdogan, O.; Erkek, E.; Atasoy, P.; Birol, A.Background Psoriasis is an inflammatory skin disease characterized by epidermal hyperplasia and greatly accelerated epidermal turnover. The blockage of normal apoptotic process in the epidermis is one of the factors implicated in the pathogenesis of psoriasis. Objective The purpose of the present study was to elucidate whether bcl-family proteins are significantly involved in the hypothetical antiapoptotic cascade in lesional psoriatic epidermis. Methods Twenty-six lesional biopsy samples of 26 patients with psoriasis and five control specimens from normal skin were studied by immunohistochemical method for the differential expression of pro-apoptotic bax and antiapoptotic bcl-2 and bcl-x proteins. Results Compared with the normal epidermis, bcl-2 expression was significantly reduced, whereas bax and bcl-x were significantly overexpressed in the psoriatic epidermis. The localization of bcl-2/bax/bcl-x proteins in the psoriatic epidermis did not show a significant deviation from that in the normal epidermis. Conclusion These findings indicate a discordant expression of bcl-2 and bax/bcl-x in psoriatic epidermis. Increased bcl-x expression might contribute to the antiapoptotic response in psoriatic keratinocytes. The presence of strong bax expression with a concomitant decrease in bcl-2 expression suggests either a functional defect in bax protein or an inherent/acquired resistance to bax-mediated apoptosis in psoriatic keratinocytes.Öğe Expressions of MMP2, MMP9, and TIMP-1 in the inflammatory cells of nasal polyps: granulocytes, monocytes, and mast cells(Verduci Publisher, 2023) Muluk, N. Bayar; Arikan, O. K.; Atasoy, P.; Kilic, R.; Yalcinozan, E. TunaOBJECTIVE: We investigated the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp (NP) pathogenesis. PATIENTS AND METHODS: In group 1 (n = 24), polyp specimens were obtained from maxillary sinus, ethmoid sinus, and nasal cavity. In group 2 without NP (control) (n = 11), inferior turbinate samples were taken. Inflammatory cell count and MMP2, MMP9 and tissue inhibitor of metalloproteinase-1 ( TIMP-1), positivity indexes (PIs) were evaluated. RESULTS: Granulocyte and mast cell-MMP2 and MMP9-PI were higher than the rate of monocyte-MMP2-PI and monocyte-MMP9-PI, respectively, in the ethmoid sinus, maxillary sinus, and nasal cavity. Mast Cell-TIMP1-PI was higher than the rates of granulocyte-TIMP1-PI and monocyte-TIMP1-PI in the maxillary sinus and was higher than the rate of monocyte-TIMP1-PI in the ethmoid sinus. CONCLUSIONS: Excessive MMP2 and MMP9, compared to TIMP1, are present in granulocytes and mast cells, respectively. With matrix MMPs, the extracellular matrix is destroyed, leading inflammatory cells to pass through, causing polypoid degeneration.Öğe Fas-mediated pathway and apoptosis in normal, hyperplastic, and neoplastic endometrium(Academic Press Inc Elsevier Science, 2003) Atasoy, P.; Bozdogan, O.; Erekul, S.; Bozdogan, N.; Bayram, M.Introduction. Abnormalities in the control of cell proliferation and apoptosis have been suggested to contribute to the development and progression of neoplasia. There are at least two pathways that activate apoptosis. The first is a mitochondria-dependent route governed by bcl-2 family proteins. The second is a parallel mechanism which involves the activation of a group of tumor necrosis factor (TNF) receptors, such as Fas. Aims. The aim of this study was to examine the distribution and interrelation between the expression patterns of apoptosis-related proteins such as Fas, caspase-3 (CPP32), and M30, and to investigate the role of Fas-mediated apoptosis in the pathogenesis and progression of endometrial neoplasms. Materials and methods. Using specific antibodies for Fas, caspase-3, and M30, we examined protein expressions in 29 endometrial carcinomas, 30 endometrial hyperplasias, and 21 normal cyclic endometria. The results of immunostaining for Fas and caspase-3 were analyzed semiquantitatively by using an immunohistochemical scoring system (HSCORE) that incorporated both the intensity and the distribution of specific staining. For M30, positive staining cells and extracellular particles were analyzed semiquantitatively per 10 high-power fields. Results. HSCOREs of Fas and caspase-3 were slightly higher in the secretory endometria than in the proliferative endometria. Similarly, M30 reactivity seemed to increase in the late secretory phase of the cycle. HSCOREs of Fas and caspase-3 and the reactivity of M30 were significantly higher in the carcinoma group than in the simple hyperplasia group (P < 0.05). Complex hyperplasias, however, expressed quite similar HSCOREs of Fas and caspase-3 as carcinomas. M30 reactivity was also significantly higher in complex hyperplasias than in simple hyperplasias, and in carcinomas positivity increased significantly (P < 0.05) as the grade progressed. Conclusions. The significant increase observed in Fas, caspase-3, and M30 expression in carcinomas as compared with simple hyperplasias may suggest that the Fas-related apoptotic pathway is also involved in the regulation of apoptosis in the endometrial tissue and promotes the development and progression of endometrial neoplasia. (C) 2003 Elsevier Inc. All rights reserved.Öğe First multifocal bullous fixed drug eruption due to etodolac(Elsevier Espana Slu, 2014) Kalkan, I. Koca; Kalpaklioglu, A. F.; Atasoy, P.; Karabulut, A. A.…Öğe Focal acral hyperkeratosis: A rare cutaneous disorder within the spectrum of costa acrokeratoelastoidosis(Wiley, 2004) Erkek, E.; Kocak, M.; Bozdogan, Ö.; Atasoy, P.; Birol, A.Acrokeratoelastoidosis and focal acral hyperkeratosis share similar clinical features and identical histologic epidermal alterations. These disorders are distinguished solely on the basis of the absence of elastorrhexis in the latter. We present a case of focal acral hyperkeratosis in a 9-year-old girl. The lesions consisted of translucent polygonal papules clustered on the thenar regions of the palms and over the metacarpophalangeal and interphalangeal joints. Histopathologic examination revealed orthohyperkeratosis within focal clavus-like depressions of the epidermis and prominent hypergranulosis. There was no evidence of alterations in elastic tissue. The clinicopathologic distinction between focal acral hyperkeratosis and acrokeratoelastoidosis is blurred. There is enough evidence to consider the former as a histologic variant of Costa acrokeratoelastoidosis syndrome, and a better nomenclature for this disorder would be "acrokeratoelastoidosis without elastorrhexis."Öğe Inducible nitric oxide synthase (iNOS) in sinonasal polyp pathogenesis(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2013) Muluk, N. Bayar; Arikan, O. K.; Atasoy, P.; Kilic, R.; Yalcinozan, E. TunaObjectives: We investigated the role of inducible nitric oxide synthase (iNOS) in the pathogenesis of sinonasal polyps. Methods: Adult patients (21 men, 3 women) with nasal polyposis underwent functional endoscopic sinus surgery. Nine adults without polyps (6 men) who underwent septoplasty and/or rhinoplasty served as controls. Polyp specimens came from three regions: the maxillary sinus (10), ethmoid sinus (14), and nasal cavity (10). Control group samples (9) came from the inferior turbinate. Specimens were evaluated in eight mucosal layers for count and distribution of inflammatory cells and iNOS expression. An iNOS positivity index (PI) was determined for the epithelium (E), subepithelial layer of the lamina propria (SE), and deep paraglandular layer of the mucosa (D). Results: Polymorphonuclear cell (PMNC) % values of the ethmoid and maxillary sinus and overall ethmoid sinus PI were significantly higher in the polyp group. Patients with longer polyp duration, D-perivascular (D-pv), and a higher Brinkmann index had decreased ethmoid sinus D Pis. However, in older patients and patients with longer polyp duration, perivascular PIs increased in maxillary sinus SE and D, respectively. Furthermore, as PMNC % and iNOS-PMNC PI increased, SE_glandular and epithelial_apical iNOS values decreased. In the ethmoid and maxillary sinuses, iNOS_D_endothelial values increased but decreased in the nasal cavity. Conclusions: iNOS may play a role in sinonasal polyp pathogenesis, especially in mucosal SE and D layers. Increased vascular permeability, stromal edema, inflammatory cell migration into the stroma of the mucosa, and increased mucosal gland secretion may result in polyp formation.Öğe Localization of T cells and subtypes in the paranasal sinus and turbinate mucosa in patients with chronic sinusitis(B C Decker Inc, 2004) Muluk, N.B.; Koc, C.; Atasoy, P.The aim of this study was to quantitate total T lymphocytes (total CD3+ cells) and T-lymphocyte subtypes (CD4+ [T helper] and CD8+ [T suppressor] cells) in patients with chronic sinusitis, who were treated with functional endoscopic sinus surgery (FESS) and to investigate the pathophysiology of persistent inflammation in chronic sinusitis. This prospective study was conducted in study and control groups. The study group consisted of 32 patients (20 male, 12 female) with chronic sinusitis who underwent FESS. The control group consisted of 8 nonsinusitis patients (5 male, 3 female) who underwent septoplasty. Specimens from the study group were excised from five regions: the uncinate process, maxillary and ethmoid sinuses, and middle and inferior turbinates. The specimens were examined with x10 magnification by light microscopy, and the slides with a severe inflammatory process were included. Punch biopsy of the control group was taken from the inferior turbinate with patients' written approval. The surgical specimens from the study and control groups were examined with an immunohistochemical staining technique with monoclonal antibodies against CD3, CD4, and CD8 surface antigens of T lymphocytes. In every specimen, the numbers of CD3+, CD4+, and CD8+ cells were-calculated in 3 to 4 high magnification field on light microscopy, and the mean number of these cells in the epithelium, subepithelial layer of the lamina propria, and deep paraglandular layer of the mucosa was determined. Statistical analysis by Kruskal-Wallis analysis of variance and the Mann-Whitney U test with Bonferroni correction revealed that the CD3 epithelial layer value of the inferior turbinate (p = .030) and the CD4 deep layer value of the middle turbinate (p = .048) were significantly higher than the corresponding values of the control group. In the epithelial (p = .018) and subepithelial (p = .012) layers of the uncinate process group, in the epithelial (p = .050) and subepithelial (p = .012) layers of the ethmoid sinus group, and in the subepithelial (p = .018) and deep paraglandular (p = .012) layers of the middle, turbinate group, the difference between the CD4+ and CD8+ cell counts was found to be statistically significant by the Wilcoxon signed rank test. The number of CD4+ cells was higher than the number of CD8+ cells. In conclusion, T cells play a role in the pathophysiology of chronic sinusitis. CD4+ T helper cells, in particular, are predominant at the initiation and regulation of inflammation. The uncinate process, ethmoid sinus, and middle and inferior turbinates have the main roles by T cells and subtypes in the defense system in chronic sinusitis.Öğe Myometrial involvement of tumor-like cystic endosalpingiosis: a rare entity(John Wiley & Sons Ltd, 2008) Cil, A. P.; Atasoy, P.; Kara, S. A.Endosalpingiosis is characterized by the presence of benign glands lined by tubal-type epithelium involving the pelvic and lower abdominal peritoneum and pelvic and para-aortic lymph nodes in women. Rarely, cystiflcation can occur, resulting in a neoplasm-like mass associated with clinical manifestations, an intraoperative abnormality, or a striking finding on gross examination. Here we report the transvaginal ultrasound, magnetic resonance imaging and bistopathological appearance of an unusual case of cystic endosalpingiosis involving the right ovary and full thickness of the wall of the uterine fundus in a patient who presented with a 6-month history of menor-rhagia and pelvic pain. Clinicians should be aware of this type of uterine benign manifestation so as to refrain from overtreatment. Copyright (c) 2008 ISUOG. Published by John Wiley & Sons, Ltd.Öğe Prostatic urethral leukoplakia with prostatic abscess(Taylor & Francis As, 2002) Küpeli, S.; Yilmaz, E.; Atasoy, P.; Tulunay, O.We present a case of prostatic abscess and coexistent leukoplakia of the urethra in a 51-year-old man. He had been suffering from diabetes mellitus for 10 years and following cessation of high fewer, transurethral electrovaporesection was performed.Öğe Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion- induced ischaemia/reperfusion injury in rats(Wiley-Blackwell, 2016) Tuglu, D.; Yuvanc, E.; Ozan, T.; Bal, F.; Yilmaz, E.; Atasoy, P.; Batislam, E.The aim of this study was to investigate the antioxidant properties of udenafil citrate (1.4 mg kg(-1)-2.8 mg kg(-1)), dexmedetomidine 25 mu g kg(-1) and piracetam 200 mg kg(-1) administered on ipsilateral/contralateral testes after ischaemia in a rat model of testicular torsion/detorsion (T/D) and define its protective effect histologically. Fifty-six Wistar albino rats were included and randomly assigned into 6 groups. No intervention was performed in control group (Group 1, n = 8) and in torsion/detorsion group, (Group 2, n = 8). Udenafil 1.4 mg kg(-1) was given to torsion/detorsion group (Group 3, n = 10), udenafil 2.8 mg kg(-1) was given to torsion/detorsion group (Group 4, n = 10), piracetam 200 mg kg(-1) was given to torsion/detorsion group (Group 5, n = 10) and dexmedetomidine 25 mu g kg(-1) was given to torsion/detorsion group (Group 6, n = 10) intraperitoneally after 60 mins of testicular torsion. Biochemical and histopathological testicular injury were evaluated. When the tissue was examined by TOS values, Group 3, Group 4 and Group 5 were significantly lower than Group 2. In contrary Group 6 values were significantly higher than Group 2. The increasing doses of udenafil demonstrated antioxidant properties on the testis tissue and histopathological that protects the testicles.Öğe Ruptured cystic teratoma associated with mucinous cystadenoma in a pregnant woman(Wolters Kluwer Medknow Publications, 2019) Aydin, O.; Pehlivanli, F.; Karaca, G.; Aydin, G.; Sayan, C. D.; Atasoy, P.; Daphan, C. E.Mature cystic teratoma is the most common ovarian neoplasm. However, mucinous cystadenoma with teratoma has been very rarely reported in literature. This case report, which is very rare, describes a clinical entity not previously reported in literature. A 34-year-old pregnant woman presented in the 23rd gestational week with severe right lower quadrant pain. She was diagnosed with acute abdomen and was then treated surgically. During the surgical intervention, a spontaneously ruptured mass was detected in the right ovary. This was reported histopathologically as a mature cystic teratoma in collision with mucinous cystadenoma. To the best of our knowledge, this case report is the first to have identified a ruptured mature cystic teratoma in collision with mucinous cystadenoma in a pregnant woman.Öğe An uncommon soft tissue tumour of the chest wall: Dermatofibrosarcoma protuberans(Acta Medical Belgica, 2006) Kara, M.; Saray, A.; Dikmen, E.; Atasoy, P.Dermatofibrosarcoma protuberans is a slow-growing tumour with propensity for local recurrence. We report herein a case of a 36-year-old man, who presented with a huge, recurrent tumour arising from the left upper anterior part of his chest wall. We performed a wide excision with 4 cm free skin margins. Reconstruction was performed with a pedicled latissimus dorsi musculocutaneous flap and free split skin grafts. Histologic and immunohistochemical studies revealed the lesion to be dermatofibrosarcoma protuberans.Öğe Unilateral lesions in a patient with keratosis follicularis(European Acad Dermatology & Venereology, 2001) Erkek, E.; Atasoy, P.…
