Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion- induced ischaemia/reperfusion injury in rats
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to investigate the antioxidant properties of udenafil citrate (1.4 mg kg(-1)-2.8 mg kg(-1)), dexmedetomidine 25 mu g kg(-1) and piracetam 200 mg kg(-1) administered on ipsilateral/contralateral testes after ischaemia in a rat model of testicular torsion/detorsion (T/D) and define its protective effect histologically. Fifty-six Wistar albino rats were included and randomly assigned into 6 groups. No intervention was performed in control group (Group 1, n = 8) and in torsion/detorsion group, (Group 2, n = 8). Udenafil 1.4 mg kg(-1) was given to torsion/detorsion group (Group 3, n = 10), udenafil 2.8 mg kg(-1) was given to torsion/detorsion group (Group 4, n = 10), piracetam 200 mg kg(-1) was given to torsion/detorsion group (Group 5, n = 10) and dexmedetomidine 25 mu g kg(-1) was given to torsion/detorsion group (Group 6, n = 10) intraperitoneally after 60 mins of testicular torsion. Biochemical and histopathological testicular injury were evaluated. When the tissue was examined by TOS values, Group 3, Group 4 and Group 5 were significantly lower than Group 2. In contrary Group 6 values were significantly higher than Group 2. The increasing doses of udenafil demonstrated antioxidant properties on the testis tissue and histopathological that protects the testicles.
Açıklama
KISA, Ucler/0000-0002-8131-6810; Batislam, Ertan/0000-0002-7493-4573
Anahtar Kelimeler
Dexmedetomidine, piracetam, total antioxidant capacity (TAC), total oxidant status (TOS), udenafil
Kaynak
Andrologia
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
48
Sayı
6
Künye
closedAccess
