Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion- induced ischaemia/reperfusion injury in rats

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dc.contributor.authorTuglu, D.
dc.contributor.authorYuvanc, E.
dc.contributor.authorOzan, T.
dc.contributor.authorBal, F.
dc.contributor.authorYilmaz, E.
dc.contributor.authorAtasoy, P.
dc.contributor.authorBatislam, E.
dc.date.accessioned2020-06-25T18:16:23Z
dc.date.available2020-06-25T18:16:23Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Batislam, Ertan/0000-0002-7493-4573
dc.description.abstractThe aim of this study was to investigate the antioxidant properties of udenafil citrate (1.4 mg kg(-1)-2.8 mg kg(-1)), dexmedetomidine 25 mu g kg(-1) and piracetam 200 mg kg(-1) administered on ipsilateral/contralateral testes after ischaemia in a rat model of testicular torsion/detorsion (T/D) and define its protective effect histologically. Fifty-six Wistar albino rats were included and randomly assigned into 6 groups. No intervention was performed in control group (Group 1, n = 8) and in torsion/detorsion group, (Group 2, n = 8). Udenafil 1.4 mg kg(-1) was given to torsion/detorsion group (Group 3, n = 10), udenafil 2.8 mg kg(-1) was given to torsion/detorsion group (Group 4, n = 10), piracetam 200 mg kg(-1) was given to torsion/detorsion group (Group 5, n = 10) and dexmedetomidine 25 mu g kg(-1) was given to torsion/detorsion group (Group 6, n = 10) intraperitoneally after 60 mins of testicular torsion. Biochemical and histopathological testicular injury were evaluated. When the tissue was examined by TOS values, Group 3, Group 4 and Group 5 were significantly lower than Group 2. In contrary Group 6 values were significantly higher than Group 2. The increasing doses of udenafil demonstrated antioxidant properties on the testis tissue and histopathological that protects the testicles.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/and.12499
dc.identifier.endpage682en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid26589469
dc.identifier.scopus2-s2.0-84977532430
dc.identifier.scopusqualityQ1
dc.identifier.startpage676en_US
dc.identifier.urihttps://doi.org/10.1111/and.12499
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6513
dc.identifier.volume48en_US
dc.identifier.wosWOS:000380894600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectpiracetamen_US
dc.subjecttotal antioxidant capacity (TAC)en_US
dc.subjecttotal oxidant status (TOS)en_US
dc.subjectudenafilen_US
dc.titleProtective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion- induced ischaemia/reperfusion injury in ratsen_US
dc.typeArticle

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