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    Effects of boric acid on experimental periodontitis and alveolar bone loss in rats
    (Pergamon-Elsevier Science Ltd, 2012) Demirer, Serhat; Kara, M. Isa; Erciyas, Kamile; Ozdemir, Hakan; Ozer, Hatice; Ay, Sinan
    Objective: The goal of the present study was to evaluate the histopathologic and morphometric effects of systemic boric acid in a rat periodontitis model. Design: Twenty-four Wistar rats were divided into three groups of eight animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3 mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the mandibular first molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups. Results: The ratio of presence of inflammatory cell infiltration (ICI) and osteoclast number in the LO group was significantly higher than that of the NL and BA groups (p < 0.05). The ratio of presence of osteoblastic activity in the LO group was significantly lower than that of the NL and BA groups (p < 0.05). Alveolar bone loss was also significantly higher in the LO group compared to the BA and NL groups (p < 005). Conclusions: This study has demonstrated that systemic administration of boric acid reduced periodontal inflammation and alveolar bone loss in periodontal disease in rats. (C) 2011 Elsevier Ltd. All rights reserved.
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    Periodontal Healing of Marginal Flap Versus Paramarginal Flap in Palatally Impacted Canine Surgery: A Prospective Study
    (W B Saunders Co-Elsevier Inc, 2009) Kosger, Hueseyin; Polat, Hidayet B.; Demirer, Serhat; Ozdemir, Hakan; Ay, Sinan
    Purpose: The aim of the present study was to compare the influence of 2 mucoperiosteal flaps, marginal and paramarginal, on the periodontal healing of adjacent maxillary teeth after extraction of palatally impacted canines. Patients and Methods: Marginal (15 patients) and paramarginal (16 patients) techniques were used to remove palatally impacted canines. The periodontal examination of the adjacent teeth included evaluation of the plaque index, gingival index, probing depth, and clinical crown length preoperatively and at the first, third, and sixth months postoperatively using an individual acrylic stent. Results: No significant differences between the marginal and paramarginal flaps were found with respect to plaque index, gingival index, labial and palatal probing depth, and labial and palatal clinical crown length at all follow-up points. Conclusion: The results of our study have shown that the paramarginal flap design is a good alternative to the marginal flap design. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67: 1826-1831, 2009