Effects of boric acid on experimental periodontitis and alveolar bone loss in rats
Yükleniyor...
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The goal of the present study was to evaluate the histopathologic and morphometric effects of systemic boric acid in a rat periodontitis model. Design: Twenty-four Wistar rats were divided into three groups of eight animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3 mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the mandibular first molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups. Results: The ratio of presence of inflammatory cell infiltration (ICI) and osteoclast number in the LO group was significantly higher than that of the NL and BA groups (p < 0.05). The ratio of presence of osteoblastic activity in the LO group was significantly lower than that of the NL and BA groups (p < 0.05). Alveolar bone loss was also significantly higher in the LO group compared to the BA and NL groups (p < 005). Conclusions: This study has demonstrated that systemic administration of boric acid reduced periodontal inflammation and alveolar bone loss in periodontal disease in rats. (C) 2011 Elsevier Ltd. All rights reserved.
Açıklama
erciyas, kamile/0000-0001-9940-0423
Anahtar Kelimeler
Experimental periodontitis, Rat, Oxidative stress, Antioxidant
Kaynak
Archives Of Oral Biology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
57
Sayı
1
Künye
closedAccess
