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Öğe Efficacy and safety of H1-antihistamines: An update(2012) Kalpaklioglu, Füsun; Baccioglu, AyşeH1-antihistamines are inverse agonists that combine with and stabilize inactive conformation of H1-receptors. Thus they interfere with actions of histamine at H1-receptors. They are widely used for treatment of allergic rhinitis, allergic conjunctivitis, urticaria, coughs, colds and insomnia. H1-antihistamines are classified as older 'first generation' and newer 'second generation'. First generation H1-antihistamines have poor receptor H1-receptor selectivity, and cross blood-brain-barrier. They have a lot of adverse events such as anti-muscarinic, anti-?-adrenergic, anti-serotonin, and sedative effects. In contrast, second generation H1-antihistamines were highly selective for the histamine H1-receptor, do not cross the blood brain barrier, and have minimal adverse events. The risks of first-generation H1-antihistamines have been clearly underestimated, particularly when purchased as nonprescribed over the counter medications by public. This review summarizes curent literature to evaluate antihistamines including their mechanism, indications and side-effects. © 2012 Bentham Science Publishers.Öğe Evaluation of adherence and safety of subcutaneous immunotherapy with aeroallergens in real life(WILEY, 2020) Baccioglu, Ayşe; Kalpaklioglu, Ayşe Füsun; Poyraz, M.; Dumanoglu, B.; Cimşir, Öksüzer D.[Özet Yok]Öğe Physicians' preference for controller medication in mild persistent asthma (conferenceObject)(Wiley-Blackwell, 2016) Bakırtaş, Arzu; Kutlu, Ali; Baccioglu, Ayşe; Erkekol, Öner Ferda; Bavbek, Sevim; Kalaycı, Ömer…










