Efficacy and safety of H1-antihistamines: An update
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Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
H1-antihistamines are inverse agonists that combine with and stabilize inactive conformation of H1-receptors. Thus they interfere with actions of histamine at H1-receptors. They are widely used for treatment of allergic rhinitis, allergic conjunctivitis, urticaria, coughs, colds and insomnia. H1-antihistamines are classified as older 'first generation' and newer 'second generation'. First generation H1-antihistamines have poor receptor H1-receptor selectivity, and cross blood-brain-barrier. They have a lot of adverse events such as anti-muscarinic, anti-?-adrenergic, anti-serotonin, and sedative effects. In contrast, second generation H1-antihistamines were highly selective for the histamine H1-receptor, do not cross the blood brain barrier, and have minimal adverse events. The risks of first-generation H1-antihistamines have been clearly underestimated, particularly when purchased as nonprescribed over the counter medications by public. This review summarizes curent literature to evaluate antihistamines including their mechanism, indications and side-effects. © 2012 Bentham Science Publishers.
Açıklama
Anahtar Kelimeler
Adverse events, Allergic rhinitis, Antihistamine(s), Atopic dermatitis, Cardiotoxicity, Histamine, Pharmacology, Receptor, Sleep, Urticaria
Kaynak
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
11
Sayı
3
