Efficacy and safety of H1-antihistamines: An update

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dc.contributor.authorKalpaklioglu F.
dc.contributor.authorBaccioglu A.
dc.date.accessioned2020-06-25T15:17:14Z
dc.date.available2020-06-25T15:17:14Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractH1-antihistamines are inverse agonists that combine with and stabilize inactive conformation of H1-receptors. Thus they interfere with actions of histamine at H1-receptors. They are widely used for treatment of allergic rhinitis, allergic conjunctivitis, urticaria, coughs, colds and insomnia. H1-antihistamines are classified as older 'first generation' and newer 'second generation'. First generation H1-antihistamines have poor receptor H1-receptor selectivity, and cross blood-brain-barrier. They have a lot of adverse events such as anti-muscarinic, anti-?-adrenergic, anti-serotonin, and sedative effects. In contrast, second generation H1-antihistamines were highly selective for the histamine H1-receptor, do not cross the blood brain barrier, and have minimal adverse events. The risks of first-generation H1-antihistamines have been clearly underestimated, particularly when purchased as nonprescribed over the counter medications by public. This review summarizes curent literature to evaluate antihistamines including their mechanism, indications and side-effects. © 2012 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1871523011202030230
dc.identifier.endpage237en_US
dc.identifier.issn18715230
dc.identifier.issue3en_US
dc.identifier.pmid23173575
dc.identifier.scopus2-s2.0-84876528695
dc.identifier.scopusqualityQ3
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.2174/1871523011202030230
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2216
dc.identifier.volume11en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdverse eventsen_US
dc.subjectAllergic rhinitisen_US
dc.subjectAntihistamine(s)en_US
dc.subjectAtopic dermatitisen_US
dc.subjectCardiotoxicityen_US
dc.subjectHistamineen_US
dc.subjectPharmacologyen_US
dc.subjectReceptoren_US
dc.subjectSleepen_US
dc.subjectUrticariaen_US
dc.titleEfficacy and safety of H1-antihistamines: An updateen_US
dc.typeReview Article

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